Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1837 | 0.1837 |
Echinococcus multilocularis | integrin alpha ps | 0.0152 | 0.1273 | 0.1792 |
Echinococcus granulosus | integrin alpha 3 | 0.0261 | 0.3009 | 0.4236 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0102 |
Echinococcus granulosus | integrin alpha ps | 0.0152 | 0.1273 | 0.1792 |
Echinococcus multilocularis | integrin beta 2 | 0.0516 | 0.7104 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.034 | 0.4282 | 0.4251 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.311 | 0.311 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0524 | 0.7236 | 0.7236 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0102 |
Loa Loa (eye worm) | integrin beta-2 | 0.0696 | 1 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0079 | 0.0101 | 0.0187 |
Brugia malayi | Kelch motif family protein | 0.0106 | 0.0525 | 0.0473 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0055 | 0.0077 |
Echinococcus granulosus | integrin beta 2 | 0.0516 | 0.7104 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0102 |
Schistosoma mansoni | integrin beta subunit | 0.041 | 0.5407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0525 | 0.0525 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.2954 | 0.2954 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0101 | 0.0101 |
Echinococcus multilocularis | integrin alpha 3 | 0.0261 | 0.3009 | 0.4236 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0102 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0106 | 0.0525 | 0.0525 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0525 | 0.0473 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0055 | 0.0055 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0257 | 0.2954 | 0.2915 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0055 | 0.0055 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0055 | 0.0077 |
Schistosoma mansoni | integrin alpha | 0.034 | 0.4282 | 0.7921 |
Echinococcus multilocularis | integrin alpha ps | 0.0152 | 0.1273 | 0.1792 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0055 | 0.0055 |
Schistosoma mansoni | integrin alpha-ps | 0.0152 | 0.1273 | 0.2355 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0102 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.