Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0013 | 0.0267 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.0267 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0.0267 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0013 | 0.0267 | 0.0267 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0013 | 0.0267 | 0.0516 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0013 | 0.0267 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0013 | 0.0267 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0079 | 0.5176 | 0.5176 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0013 | 0.0267 | 0.0516 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0013 | 0.0267 | 0.0516 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.5176 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0079 | 0.5176 | 1 |
Echinococcus multilocularis | neuroligin | 0.0013 | 0.0267 | 0.0516 |
Onchocerca volvulus | 0.0013 | 0.0267 | 0.5 | |
Schistosoma mansoni | acetylcholinesterase | 0.0013 | 0.0267 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0267 | 0.0267 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0013 | 0.0267 | 0.0516 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.5176 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0013 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0267 | 0.0267 |
Schistosoma mansoni | gliotactin | 0.0013 | 0.0267 | 0.0516 |
Brugia malayi | Carboxylesterase family protein | 0.0013 | 0.0267 | 0.0267 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0013 | 0.0267 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5176 | 0.5176 |
Brugia malayi | Carboxylesterase family protein | 0.0013 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | carboxylesterase | 0.0079 | 0.5176 | 0.5176 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0013 | 0.0267 | 0.0516 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0013 | 0.0267 | 0.0516 |
Onchocerca volvulus | 0.0013 | 0.0267 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0013 | 0.0267 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.5176 | 0.5176 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0013 | 0.0267 | 0.0516 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.5176 | 0.5176 |
Loa Loa (eye worm) | carboxylesterase | 0.0013 | 0.0267 | 0.0267 |
Echinococcus granulosus | neuroligin | 0.0013 | 0.0267 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5176 | 0.5176 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0013 | 0.0267 | 0.0516 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0267 | 0.0267 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0013 | 0.0267 | 0.0516 |
Echinococcus granulosus | carboxylesterase 5A | 0.0079 | 0.5176 | 1 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0267 | 0.0267 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0079 | 0.5176 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.5176 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0013 | 0.0267 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0267 | 0.0267 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0013 | 0.0267 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.5176 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0013 | 0.0267 | 0.0267 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0013 | 0.0267 | 0.0516 |
Onchocerca volvulus | 0.0013 | 0.0267 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.