Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | squalene synthase, putative | 0.0257 | 0.0317 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0473 | 0.0844 | 0.0828 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.1312 | 0.2886 | 0.483 |
Schistosoma mansoni | sex comb on midleg homolog | 0.1312 | 0.2886 | 0.2874 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.1616 | 0.3626 | 0.6074 |
Loa Loa (eye worm) | mbt repeat family protein | 0.1366 | 0.3016 | 0.58 |
Schistosoma mansoni | phd finger protein | 0.0201 | 0.0182 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.2258 | 0.5187 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.1901 | 0.4318 | 0.7239 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.2575 | 0.5958 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.1901 | 0.4318 | 0.7239 |
Brugia malayi | Cation transporter family protein | 0.0245 | 0.0288 | 0.0523 |
Brugia malayi | jmjC domain containing protein | 0.0677 | 0.1339 | 0.2556 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0473 | 0.0844 | 0.1392 |
Echinococcus granulosus | chromobox protein 2 | 0.0973 | 0.2061 | 0.3441 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0245 | 0.0288 | 0.0271 |
Plasmodium vivax | JmjC domain containing protein | 0.0144 | 0.0042 | 0.5 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0564 | 0.1064 | 0.1762 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.046 | 0.0811 | 0.0795 |
Brugia malayi | mbt repeat family protein | 0.2258 | 0.5187 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0257 | 0.0317 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0257 | 0.0317 | 0.5 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.2575 | 0.5958 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 0.0844 | 0.16 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0383 | 0.0624 | 0.1022 |
Schistosoma mansoni | chromobox protein | 0.0973 | 0.2061 | 0.2047 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0245 | 0.0288 | 0.0271 |
Toxoplasma gondii | PLU-1 family protein | 0.0217 | 0.0221 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0677 | 0.1339 | 0.2556 |
Schistosoma mansoni | hypothetical protein | 0.1616 | 0.3626 | 0.3615 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.046 | 0.0811 | 0.0795 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.2258 | 0.5187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.0288 | 0.0523 |
Schistosoma mansoni | sex comb on midleg homolog | 0.1312 | 0.2886 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.0288 | 0.0523 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0473 | 0.0844 | 0.1392 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.1616 | 0.3626 | 0.6074 |
Echinococcus multilocularis | histone acetyltransferase myst3 | 0.0201 | 0.0182 | 0.0277 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0473 | 0.0844 | 0.1392 |
Leishmania major | squalene synthase, putative | 0.0257 | 0.0317 | 0.5 |
Echinococcus multilocularis | chromobox protein 2 | 0.0973 | 0.2061 | 0.3441 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.046 | 0.0811 | 0.1336 |
Echinococcus granulosus | histone acetyltransferase myst3 | 0.0201 | 0.0182 | 0.0277 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0144 | 0.0042 | 0.5 |
Onchocerca volvulus | 0.149 | 0.3319 | 0.6187 | |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0473 | 0.0844 | 0.1392 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.016 | 0.0081 | 0.3694 |
Loa Loa (eye worm) | MBCTL1 | 0.0473 | 0.0844 | 0.16 |
Brugia malayi | mbt repeat family protein | 0.1366 | 0.3016 | 0.58 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.1901 | 0.4318 | 0.4308 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0564 | 0.1064 | 0.1762 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0473 | 0.0844 | 0.16 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.1312 | 0.2886 | 0.483 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.0175 | 0.0304 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.