Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0205 | 0.021 | 1 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0205 | 0.021 | 0.0529 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.016 | 0.016 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0175 | 0.0173 | 0.7347 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0205 | 0.021 | 0.1216 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.0152 | 0.0152 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0205 | 0.021 | 0.021 |
Schistosoma mansoni | sodium/calcium exchanger | 0.8134 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.016 | 0.016 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0205 | 0.021 | 0.0529 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1435 | 0.1728 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0175 | 0.0173 | 0.0435 |
Echinococcus multilocularis | sodium calcium exchanger | 0.8134 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.0152 | 0.0152 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1435 | 0.1728 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0205 | 0.021 | 0.1216 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0205 | 0.021 | 1 |
Plasmodium falciparum | cation/H+ antiporter | 0.0205 | 0.021 | 0.5 |
Brugia malayi | Sodium/calcium exchanger protein | 0.3254 | 0.3974 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.0152 | 0.0382 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0205 | 0.021 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0205 | 0.021 | 0.021 |
Treponema pallidum | hypothetical protein | 0.0205 | 0.021 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.016 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.021 | 0.021 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0205 | 0.021 | 0.021 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.0125 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.021 | 0.021 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0205 | 0.021 | 0.1216 |
Loa Loa (eye worm) | solute carrier family 8 | 0.8134 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.0125 | 0.0125 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0205 | 0.021 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.3254 | 0.3974 | 0.3974 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0152 | 0.0152 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0205 | 0.021 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0 | 0.5 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0205 | 0.021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.021 | 0.021 |
Schistosoma mansoni | na/ca exchanger | 0.0205 | 0.021 | 0.021 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0205 | 0.021 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.021 | 0.021 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0205 | 0.021 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0205 | 0.021 | 0.021 |
Echinococcus granulosus | geminin | 0.0164 | 0.016 | 0.016 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0173 | 0.0173 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0205 | 0.021 | 0.021 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.353 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.