Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NAD dependent deacetylase sirtuin 6 | 0.0334 | 0.0916 | 0.0916 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.162 | 1 | 1 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.1069 | 0.6109 | 0.5993 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.1069 | 0.6109 | 0.5717 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.1069 | 0.6109 | 0.5717 |
Mycobacterium ulcerans | Sir2-like regulatory protein | 0.0334 | 0.0916 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.162 | 1 | 1 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0334 | 0.0916 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.1069 | 0.6109 | 0.6109 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0334 | 0.0916 | 0.0644 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.162 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1069 | 0.6109 | 0.5993 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0735 | 0.3751 | 0.3564 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.1069 | 0.6109 | 0.5717 |
Loa Loa (eye worm) | transcriptional regulator | 0.162 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.1069 | 0.6109 | 0.5717 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.162 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.162 | 1 | 1 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.162 | 1 | 1 |
Toxoplasma gondii | histone deacetylase SIR2-like | 0.0334 | 0.0916 | 0.5 |
Loa Loa (eye worm) | transcriptional regulator | 0.0334 | 0.0916 | 0.0644 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.162 | 1 | 1 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0334 | 0.0916 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.162 | 1 | 1 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0334 | 0.0916 | 0.5 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.0334 | 0.0916 | 0.5 |
Loa Loa (eye worm) | transcriptional regulator | 0.0334 | 0.0916 | 0.0644 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 6 | 0.0334 | 0.0916 | 0.0916 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.162 | 1 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 7 | 0.0334 | 0.0916 | 0.0916 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.162 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.1069 | 0.6109 | 0.5717 |
Plasmodium vivax | hypothetical protein, conserved | 0.0334 | 0.0916 | 0.5 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0334 | 0.0916 | 0.5 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0334 | 0.0916 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.162 | 1 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.162 | 1 | 1 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 7 | 0.0334 | 0.0916 | 0.0916 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0334 | 0.0916 | 0.0644 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.1069 | 0.6109 | 0.6109 |
Leishmania major | silent information regulator 2, putative | 0.162 | 1 | 1 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.1069 | 0.6109 | 0.5717 |
Loa Loa (eye worm) | sirtuin 4 | 0.0334 | 0.0916 | 0.0644 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.162 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.6 nM | Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay | ChEMBL. | 22196514 |
IC50 (binding) | = 2 nM | Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter | ChEMBL. | 22196514 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.