Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0566 | 0.0949 | 0.2951 |
Onchocerca volvulus | 0.1327 | 0.3214 | 1 | |
Leishmania major | UDP-galactopyranose mutase | 0.0254 | 0.0019 | 0.0058 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0566 | 0.0949 | 0.2951 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0783 | 0.1595 | 0.1579 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1327 | 0.3214 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1305 | 0.3147 | 0.9792 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.3352 | 0.9244 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1327 | 0.3214 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0254 | 0.0019 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0254 | 0.0019 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1305 | 0.3147 | 0.9792 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1327 | 0.3214 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0254 | 0.0019 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0254 | 0.0019 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0783 | 0.1595 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0566 | 0.0949 | 0.2951 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0783 | 0.1595 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0783 | 0.1595 | 0.1579 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0254 | 0.0019 | 0.5 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.1327 | 0.3214 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0566 | 0.0949 | 0.2951 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0254 | 0.0019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1305 | 0.3147 | 0.9791 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1327 | 0.3214 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0254 | 0.0019 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3606 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1327 | 0.3214 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0254 | 0.0019 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0254 | 0.0019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.1528 | 0.4723 |
Giardia lamblia | Hypothetical protein | 0.0783 | 0.1595 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1305 | 0.3147 | 0.9792 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0254 | 0.0019 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1327 | 0.3214 | 1 |
Brugia malayi | hypothetical protein | 0.0254 | 0.0019 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1305 | 0.3147 | 0.9792 |
Plasmodium vivax | hypothetical protein, conserved | 0.0254 | 0.0019 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1327 | 0.3214 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0254 | 0.0019 | 0.0058 |
Brugia malayi | SWIRM domain containing protein | 0.0254 | 0.0019 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0254 | 0.0019 | 0.0058 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0254 | 0.0019 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (binding) | = 96 % | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-8 production at 1 uM relative to prednisolone | ChEMBL. | 22197391 |
IC50 (ADMET) | Transactivation of glucocorticoid receptor in rat H42E cells assessed as induction of TAT measuring degradation of tyrosine to p-hydroxy phenyl pyruvate | ChEMBL. | 22197391 | |
IC50 (binding) | = 4.4 nM | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-8 production | ChEMBL. | 22197391 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.