Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | Augmenter of liver regeneration | 0.0034 | 0.3162 | 0.3162 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.233 | 0.233 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0177 | 0.0177 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.3162 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.446 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0008 | 0.0177 | 0.0177 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0008 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0095 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.446 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0008 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.446 | 0.446 |
Brugia malayi | nuclear receptor NHR-88 | 0.0008 | 0.0177 | 0.0177 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.233 | 0.5223 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0008 | 0.0177 | 0.0397 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.3162 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.446 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0177 | 0.0177 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0008 | 0.0177 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.069 | 0.069 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0008 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0177 | 0.0177 |
Schistosoma mansoni | coup transcription factor | 0.0008 | 0.0177 | 0.0397 |
Onchocerca volvulus | 0.0027 | 0.233 | 1 | |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0008 | 0.0177 | 0.0397 |
Echinococcus multilocularis | lamin | 0.0027 | 0.233 | 0.5223 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0008 | 0.0177 | 0.0177 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.233 | 0.5223 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.446 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0008 | 0.0177 | 0.0397 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0746 | 0.1672 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0008 | 0.0177 | 0.0397 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0008 | 0.0177 | 0.0177 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.3162 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0177 | 0.0177 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0008 | 0.0177 | 0.0397 |
Echinococcus multilocularis | musashi | 0.0027 | 0.233 | 0.5223 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.446 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0008 | 0.0177 | 0.0177 |
Brugia malayi | steroid hormone receptor | 0.0008 | 0.0177 | 0.0177 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.3162 | 0.709 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0008 | 0.0177 | 0.0397 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0008 | 0.0177 | 0.0397 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.233 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0746 | 0.0746 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0008 | 0.0177 | 0.0177 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0008 | 0.0177 | 0.0397 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0008 | 0.0177 | 0.0397 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.233 | 0.233 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0008 | 0.0177 | 0.0177 |
Schistosoma mansoni | nuclear hormone receptor | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0008 | 0.0177 | 0.0177 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0008 | 0.0177 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0177 | 0.0177 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.3162 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.446 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0008 | 0.0177 | 0.0397 |
Schistosoma mansoni | lamin | 0.0027 | 0.233 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0177 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0008 | 0.0177 | 0.0177 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.233 | 0.233 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0008 | 0.0177 | 0.0177 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0008 | 0.0177 | 0.0397 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.3162 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0008 | 0.0177 | 0.0177 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.446 | 0.446 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0008 | 0.0177 | 0.0177 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0008 | 0.0177 | 0.0397 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0008 | 0.0177 | 0.0177 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.233 | 0.233 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0909 | 0.0909 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.3162 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.233 | 0.5223 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.3162 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0008 | 0.0177 | 0.0177 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0008 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0095 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.233 | 0.5223 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0008 | 0.0177 | 0.0177 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.446 | 1 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.3162 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0008 | 0.0177 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.069 | 0.069 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.3162 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0746 | 0.1672 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | ecdysteroid receptor | 0.0008 | 0.0177 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0008 | 0.0177 | 0.0177 |
Echinococcus granulosus | FTZ F1 alpha | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0008 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0909 | 0.0909 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0008 | 0.0177 | 0.0397 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0008 | 0.0177 | 0.0397 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.233 | 0.233 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0008 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2274 | 0.2274 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0008 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0034 | 0.3162 | 0.3162 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0008 | 0.0177 | 0.0397 |
Schistosoma mansoni | thyroid hormone receptor | 0.0008 | 0.0177 | 0.0397 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.233 | 0.5223 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.3162 | 0.709 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0008 | 0.0177 | 0.0397 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0008 | 0.0177 | 0.0177 |
Brugia malayi | nuclear hormone receptor | 0.0008 | 0.0177 | 0.0177 |
Onchocerca volvulus | 0.0027 | 0.233 | 1 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0008 | 0.0177 | 0.0177 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0008 | 0.0177 | 0.0397 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.407 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.396 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.97 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.868 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.727 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.717 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.712 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.711 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.606 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.586 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.364 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.