Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor delta | 441 aa | 369 aa | 24.7 % |
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hydroxyacylglutathione hydrolase | 0.0475 | 0.2338 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0432 | 0.2045 | 0.6078 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.1585 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0367 | 0.1591 | 1 |
Plasmodium vivax | glyoxalase I, putative | 0.1585 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0367 | 0.1591 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0367 | 0.1591 | 1 |
Schistosoma mansoni | hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) | 0.0475 | 0.2338 | 1 |
Onchocerca volvulus | Lactoylglutathione lyase homolog | 0.1585 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0367 | 0.1591 | 1 |
Toxoplasma gondii | hydroxyacylglutathione hydrolase | 0.0475 | 0.2338 | 0.0888 |
Plasmodium falciparum | glyoxalase I | 0.1585 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0367 | 0.1591 | 1 |
Brugia malayi | 4-hydroxyphenylpyruvate dioxygenase family protein | 0.0367 | 0.1591 | 0.1591 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.1585 | 1 | 1 |
Brugia malayi | Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. | 0.0475 | 0.2338 | 0.2338 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase | 0.0475 | 0.2338 | 0.2338 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0367 | 0.1591 | 1 |
Loa Loa (eye worm) | 4-hydroxyphenylpyruvate dioxygenase | 0.0367 | 0.1591 | 0.1591 |
Echinococcus granulosus | hydroxyacylglutathione hydrolase | 0.0475 | 0.2338 | 1 |
Toxoplasma gondii | glyoxalase I, putative | 0.1585 | 1 | 1 |
Plasmodium vivax | hydroxyacyl glutathione hydrolase, putative | 0.0475 | 0.2338 | 0.0888 |
Onchocerca volvulus | Hydroxyacylglutathione hydrolase, mitochondrial homolog | 0.0421 | 0.1963 | 0.0443 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.0475 | 0.2338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1585 | 1 | 1 |
Plasmodium falciparum | cytosolic glyoxalase II | 0.0475 | 0.2338 | 0.0888 |
Leishmania major | glyoxalase I,trypanothione-dependent glyoxalase I | 0.1585 | 1 | 1 |
Mycobacterium ulcerans | glyoxalase II, GloB | 0.0421 | 0.1963 | 1 |
Leishmania major | hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative | 0.0475 | 0.2338 | 0.0268 |
Trypanosoma brucei | hydroxyacylglutathione hydrolase, putative | 0.0475 | 0.2338 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1.5 uM | Transactivation of human PPARalpha expressed in CHO-K1 cells | ChEMBL. | 22133631 |
EC50 (binding) | > 12 uM | Transactivation of human PPARgamma expressed in CHO-K1 cells | ChEMBL. | 22133631 |
EC50 (binding) | > 13 uM | Transactivation of human PPARdelta expressed in CHO-K1 cells | ChEMBL. | 22133631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.