Detailed view for Bm1_32410

Basic information

TDR Targets ID: 239605
Brugia malayi, 4-hydroxyphenylpyruvate dioxygenase family protein
Source Database / ID:  GenBank

pI: 5.299 | Length (AA): 403 | MW (Da): 46458 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00903   Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0016701   oxidoreductase activity, acting on single donors with incorporation of molecular oxygen  
GO:0003868   4-hydroxyphenylpyruvate dioxygenase activity  
GO:0055114   oxidation reduction  
GO:0009072   aromatic amino acid family metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 393 5hmq (A) 256 626 20.00 0.0000000000062 1 1.00222 0.58
29 401 3isq (A) 9 383 37.00 0 1 1.33656 -0.71
37 384 1sqi (A) 17 366 39.00 0 1 1.30552 -0.41
254 307 4ays (A) 88 169 31.00 0.43 0.91 0.611995 -0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129448)

Species Accession Gene Product
Arabidopsis thaliana AT1G06570   4-hydroxyphenylpyruvate dioxygenase
Brugia malayi Bm1_32410   4-hydroxyphenylpyruvate dioxygenase family protein
Candida albicans CaO19.5499   similar to HPPD a 4-hydroxyphenylpyruvate dioxygenase
Candida albicans CaO19.12954   similar to HPPD a 4-hydroxyphenylpyruvate dioxygenase
Caenorhabditis elegans CELE_T21C12.2   Protein HPD-1
Dictyostelium discoideum DDB_G0277511   4-hydroxyphenylpyruvate dioxygenase
Drosophila melanogaster Dmel_CG11796   CG11796 gene product from transcript CG11796-RA
Homo sapiens ENSG00000158104   4-hydroxyphenylpyruvate dioxygenase
Loa Loa (eye worm) LOAG_02307   4-hydroxyphenylpyruvate dioxygenase
Mus musculus ENSMUSG00000029445   4-hydroxyphenylpyruvic acid dioxygenase
Oryza sativa 4328425   Os02g0168100
Onchocerca volvulus OVOC3094   Putative protein
Schmidtea mediterranea mk4.005810.00   4-hydroxyphenylpyruvate dioxygenase
Schmidtea mediterranea mk4.022933.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus 4-hydroxyphenylpyruvate dioxygenase Compounds References
Sus scrofa 4-hydroxyphenylpyruvate dioxygenase Compounds References
Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase Compounds References
Homo sapiens 4-hydroxyphenylpyruvate dioxygenase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0302 0.4142 1
0.0366 0.442 0.7098
0.1244 0.3725 0.3724
0.0298 0.3395 0.3482
0.0366 0.5443 0.9618
0.0301 0.2954 0.7047
0.0308 0.3592 0.9859
0.1244 0.3725 0.3724
0.0349 0.2512 1
0.0366 0.4254 0.7665
0.0297 0.3829 1
0.0494 0.3957 0.3957
0.0579 0.4787 1
0.0303 0.3833 1
0.1047 0.3658 0.3657
0.0314 0.31 1
0.0297 0.3644 1
0.049 0.2765 0.3975
0.0349 0.2512 1
0.5364 0.8542 1
0.0314 0.4209 1
0.0317 0.4176 1
0.063 0.8314 1
0.0296 0.2593 1
0.1001 0.4268 1
0.1049 0.3569 0.3416
0.1776 0.7525 1
0.0335 0.6555 0.7468
0.0297 0.4323 1
0.0309 0.4314 1
0.0288 0.2583 0.2583
0.0366 0.3392 1
0.0494 0.3957 0.3957
0.0305 0.2972 0.8759
0.0366 0.3963 1
0.1226 0.5983 1
0.0297 0.3447 1
0.0298 0.3395 0.3482
0.03 0.303 1
0.061 0.8516 1
0.0354 0.7723 0.7723
0.2529 0.2918 1
0.03 0.3905 1
0.0311 0.3783 0.5822
0.0628 0.438 1
0.0669 0.9253 0.9253
0.1244 0.4487 1
0.0667 0.4358 1
0.0288 0.2583 0.2583
0.0354 0.7723 0.7723
0.026 0.3843 1
0.0288 0.2583 0.2583
0.0302 0.4142 1
0.0223 0.3099 0.6132
0.0662 0.4377 1
0.0662 0.4376 1
0.1845 0.4129 1
0.1347 0.6128 0.6128
0.0669 0.9253 0.9253
0.0311 0.4834 1
0.0288 0.2583 0.2583
0.5364 0.8542 1
0.0298 0.3359 1
0.0296 0.335 1
0.0341 0.9852 0.5
0.0301 0.3586 0.4836
0.5364 0.8542 1
0.1047 0.3658 0.3657
0.0321 0.3139 1
0.0349 0.2512 1
0.9413 0.2699 1
0.0311 0.3783 0.5822
0.1244 0.3725 0.3724
0.0898 0.3161 0.3279
0.0304 0.6835 1
0.9413 0.2699 1
0.0366 0.6181 1
0.0288 0.2583 0.2583
0.0357 0.2771 1
0.0337 0.651 0.746
0.0298 0.3398 1
0.0187 0.6014 1
0.0303 0.9897 1
0.0298 0.6953 0.9867
0.1244 0.3725 0.3724
0.0337 0.9669 0.9669
0.0293 0.6531 1
0.0327 0.4398 1
0.0494 0.3957 0.3957
0.0288 0.2583 0.2583
0.0669 0.9253 0.9253
0.2385 0.3541 0.6584
0.0366 0.4404 0.5794
0.0614 0.622 1
0.0297 0.3389 0.8038
0.0366 0.515 0.4991
0.0296 0.2593 1
0.1049 0.3569 0.3416
0.0318 0.3966 1
0.0687 0.2617 0.2773
0.0298 0.3214 0.4913
0.0517 0.3993 0.3988
0.0288 0.2583 0.2583
0.9413 0.2699 1
0.032 0.4327 1
0.0301 0.3586 0.4836
0.0366 0.8944 0.8944
0.037 0.438 0.9474
0.0311 0.4321 1
0.0617 0.6643 1
0.0628 0.3812 1
0.1049 0.3569 0.3416
0.1244 0.3725 0.3724
0.158 0.8166 0.8166
0.0338 0.3937 1
0.1244 0.3725 0.3724
0.1139 0.2913 1
0.0304 0.9791 1
0.063 0.3006 0.664
0.025 0.2545 0.2545
0.095 0.3274 0.3274
0.0494 0.3957 0.3957
0.0328 0.6545 0.7488
0.0311 0.3783 0.5822
0.0304 0.9473 1
0.0305 0.6536 1
0.0302 0.3241 1
0.0302 0.6319 1
0.0311 0.3783 0.5822
0.0288 0.2583 0.2583
0.0971 0.8635 1
0.0366 0.4093 1
0.5364 0.8542 1
0.0622 0.409 1
0.0298 0.3395 0.3482
0.0366 0.8475 1
0.0898 0.3047 0.9274
0.0366 0.5517 1
0.0691 0.719 1
0.2626 0.6526 0.6741
0.0366 0.7019 1
0.1084 0.2982 0.5073
0.0311 0.3783 0.5822
0.0599 0.8968 1
0.0294 0.4423 1
0.1226 0.5983 1
0.1244 0.3722 0.3722
0.03 0.2865 1
0.0311 0.3246 0.8878
0.1344 0.3084 1
0.0302 0.43 1
0.0366 0.5556 0.553
0.0305 0.6536 1
0.5364 0.8542 1
0.0366 0.7775 0.8871
0.0669 0.9253 0.9253
0.0304 0.4771 0.8654
0.2393 0.8982 0.8957
0.5364 0.8542 1
0.0343 0.4108 0.4098
0.1202 0.8272 1
0.0534 0.5519 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_32410 (Brugia malayi), 4-hydroxyphenylpyruvate dioxygenase family protein
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