Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.074 | 0.0412 | 0.0401 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.074 | 0.0412 | 0.0401 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.6136 | 0.5812 | 0.5812 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.133 | 0.1003 | 0.0992 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.074 | 0.0412 | 0.0401 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.0322 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 1.0322 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.0322 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.0322 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.074 | 0.0412 | 0.0401 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.0322 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.034 | 0.0012 | 0.0012 |
Echinococcus granulosus | insulin receptor | 0.074 | 0.0412 | 0.0401 |
Schistosoma mansoni | tyrosine kinase | 0.074 | 0.0412 | 0.0412 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.0322 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0072 | 0.006 |
Brugia malayi | Protein kinase domain containing protein | 0.1331 | 0.1003 | 0.0993 |
Onchocerca volvulus | 1.0322 | 1 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.074 | 0.0412 | 0.0412 |
Brugia malayi | Protein kinase domain containing protein | 0.0412 | 0.0084 | 0.0072 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.4185 | 0.386 | 0.386 |
Loa Loa (eye worm) | hypothetical protein | 0.116 | 0.0833 | 0.0822 |
Schistosoma mansoni | tyrosine kinase | 0.034 | 0.0012 | 0.0012 |
Schistosoma mansoni | tyrosine kinase | 0.034 | 0.0012 | 0.0012 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.0322 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.074 | 0.0412 | 0.0401 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 1.0322 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.7 nM | Inhibitory activity against human carbonic anhydrase II | ChEMBL. | 14611846 |
Ki (binding) | = 1.7 nM | Inhibitory activity against human carbonic anhydrase II | ChEMBL. | 14611846 |
Ki (binding) | = 9 nM | Inhibitory activity of the compound against Carbonic anhydrase IV isolated from bovine lung | ChEMBL. | 14611846 |
Ki (binding) | = 9 nM | Inhibitory activity of the compound against Carbonic anhydrase IV isolated from bovine lung | ChEMBL. | 14611846 |
Ki (binding) | = 13 nM | Inhibitory activity of the compound against human carbonic anhydrase I (hCA I) | ChEMBL. | 14611846 |
Ki (binding) | = 13 nM | Inhibitory activity of the compound against human carbonic anhydrase I (hCA I) | ChEMBL. | 14611846 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.