Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | STE family protein kinase | 0.0164 | 0.0826 | 1 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0161 | 0.0809 | 0.9795 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0161 | 0.0809 | 0.9795 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.0161 | 0.0809 | 0.0885 |
Schistosoma mansoni | tyrosine kinase | 0.0161 | 0.0809 | 0.9795 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0164 | 0.0826 | 0.0903 |
Giardia lamblia | Kinase, STE STE20 | 0.0164 | 0.0826 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.1722 | 0.9142 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0164 | 0.0826 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0164 | 0.0826 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0164 | 0.0826 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.1882 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0164 | 0.0826 | 1 |
Echinococcus multilocularis | neural Wiskott Aldrich syndrome protein | 0.0161 | 0.0809 | 0.0885 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.1722 | 0.9142 | 1 |
Schistosoma mansoni | protein kinase | 0.0164 | 0.0826 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0164 | 0.0826 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0164 | 0.0826 | 0.0903 |
Trichomonas vaginalis | STE family protein kinase | 0.0164 | 0.0826 | 1 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0161 | 0.0809 | 0.0809 |
Schistosoma mansoni | protein kinase | 0.0164 | 0.0826 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0161 | 0.0809 | 0.0885 |
Schistosoma mansoni | protein kinase | 0.0161 | 0.0809 | 0.9795 |
Schistosoma mansoni | hypothetical protein | 0.0161 | 0.0809 | 0.9795 |
Brugia malayi | WH1 domain containing protein | 0.0161 | 0.0809 | 0.0809 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.0161 | 0.0809 | 0.0885 |
Entamoeba histolytica | protein kinase, putative | 0.0164 | 0.0826 | 1 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0161 | 0.0809 | 0.0809 |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.0161 | 0.0809 | 0.0885 |
Trichomonas vaginalis | STE family protein kinase | 0.0164 | 0.0826 | 1 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0161 | 0.0809 | 0.0809 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0809 | 0.0809 |
Schistosoma mansoni | hypothetical protein | 0.0161 | 0.0809 | 0.9795 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0164 | 0.0826 | 0.0903 |
Brugia malayi | Protein kinase domain | 0.0164 | 0.0826 | 0.0826 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0164 | 0.0826 | 0.0903 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0164 | 0.0826 | 0.0903 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0164 | 0.0826 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0164 | 0.0826 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0164 | 0.0826 | 0.0903 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0164 | 0.0826 | 0.0903 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0161 | 0.0809 | 0.9795 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (ADMET) | = 9 % | Transactivation of glucocorticoid receptor in rat H42E cells assessed as induction of TAT measuring degradation of tyrosine to p-hydroxy phenyl pyruvate at 1 uM relative to prednisolone | ChEMBL. | 22197391 |
Efficacy (ADMET) | = 42 % | Transactivation of glucocorticoid receptor in human HepG2 cells assessed as induction of TAT measuring degradation of tyrosine to p-hydroxy phenyl pyruvate at 1 uM relative to untreated control | ChEMBL. | 22197391 |
Efficacy (binding) | = 62 % | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-8 production at 1 uM relative to prednisolone | ChEMBL. | 22197391 |
IC50 (binding) | = 305 nM | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-8 production | ChEMBL. | 22197391 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.