Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0216 | 1 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0021 | 0.0125 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0021 | 0.0125 | 0.0125 |
Leishmania major | glutaminyl cyclase, putative | 0.0021 | 0.0125 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | nicalin | 0.0021 | 0.0125 | 0.0125 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0021 | 0.0125 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0021 | 0.0125 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0198 | 0.9065 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0021 | 0.0125 | 0.0214 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0134 | 0.5822 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0125 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0021 | 0.0125 | 0.0138 |
Brugia malayi | FXNA | 0.0021 | 0.0125 | 0.0125 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0134 | 0.5822 | 0.6422 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0125 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0125 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0021 | 0.0125 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0021 | 0.0125 | 0.0138 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0134 | 0.5822 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0134 | 0.5822 | 0.6422 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0198 | 0.9065 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.5822 | 0.5769 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0021 | 0.0125 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0021 | 0.0125 | 0.0214 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0021 | 0.0125 | 0.0214 |
Brugia malayi | Peptidase family M28 containing protein | 0.0134 | 0.5822 | 0.5822 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0021 | 0.0125 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0021 | 0.0125 | 0.0214 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0021 | 0.0125 | 0.0138 |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0.0125 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0021 | 0.0125 | 0.0138 |
Mycobacterium ulcerans | hypothetical protein | 0.0021 | 0.0125 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0021 | 0.0125 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0021 | 0.0125 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0021 | 0.0125 | 0.0138 |
Toxoplasma gondii | hypothetical protein | 0.0021 | 0.0125 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 2.5 ug ml-1 | Antiproliferative activity against human HT-29 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay | ChEMBL. | 22129061 |
IC50 (functional) | > 2.5 ug ml-1 | Antiproliferative activity against human MDA-MB-435 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay | ChEMBL. | 22129061 |
IC50 (functional) | > 2.5 ug ml-1 | Antiproliferative activity against human U937 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay | ChEMBL. | 22129061 |
IC50 (functional) | = 4.8 ug ml-1 | Antitrypanosomal activity against Trypanosoma brucei brucei clone 427-221a assessed as growth inhibition after 40 hrs by ATP-bioluminescence assay | ChEMBL. | 22129061 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 22129061 | ||
Homo sapiens | ChEMBL23 | 22129061 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.