Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GMP reductase | 0.0039 | 0.0312 | 0.0312 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.5503 | 0.5503 |
Leishmania major | histone deacetylase, putative | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.5503 | 0.5503 |
Echinococcus granulosus | histone deacetylase 6 | 0.0143 | 1 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.5503 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.8459 | 0.8459 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0143 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0143 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.5503 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0143 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0143 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.005 | 0.1284 | 0.0954 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0143 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1564 | 0.1564 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0143 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0143 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1564 | 0.1564 |
Onchocerca volvulus | Putative GMP reductase | 0.0039 | 0.0312 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | GMP reductase | 0.0039 | 0.0312 | 0.0312 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.4975 | 0.8869 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0143 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.5503 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0143 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0143 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.5503 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1564 | 0.1564 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.5503 | 0.5503 |
Plasmodium vivax | histone deacetylase, putative | 0.0143 | 1 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0143 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0143 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0143 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0143 | 1 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0143 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1564 | 0.1564 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0143 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.8459 | 0.8459 |
Echinococcus granulosus | histone deacetylase 6 | 0.0143 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0143 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0143 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0143 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.0312 | 0.0312 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.8459 | 0.8459 |
Leishmania major | histone deacetylase, putative | 0.0143 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.11 uM | Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2 | ChEMBL. | 12270168 |
IC50 (binding) | = 0.11 uM | Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2 | ChEMBL. | 12270168 |
IC50 (functional) | < 1 uM | Inhibition of human T-lymphoblast CEM cell (ATCC) proliferation; At this concentration no inhibition was observed | ChEMBL. | 12270168 |
IC50 (functional) | < 1 uM | Inhibition of human T-lymphoblast CEM cell (ATCC) proliferation; At this concentration no inhibition was observed | ChEMBL. | 12270168 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12270168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.