Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.1211 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0034 | 0.025 | 1 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.1211 | 1 | 1 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0257 | 0.0257 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0517 | 0.0517 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0517 | 0.0517 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0024 | 0.0024 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.1211 | 1 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0034 | 0.025 | 0.025 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0216 | 0.0216 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0011 | 0.0055 | 0.2207 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.013 | 0.013 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0044 | 0.0044 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.013 | 0.013 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.013 | 0.013 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0029 | 0.0029 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0011 | 0.0055 | 0.2207 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.013 | 0.013 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0517 | 0.0517 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.0494 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0029 | 0.0029 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.1211 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0029 | 0.0029 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.013 | 0.013 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0029 | 0.0029 |
Mycobacterium tuberculosis | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) | 0.042 | 0.345 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0011 | 0.0055 | 0.2207 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.0494 | 0.1432 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0517 | 0.0517 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.013 | 0.013 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.013 | 0.013 |
Echinococcus granulosus | dnaJ subfamily B | 0.0428 | 0.3517 | 0.3517 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0024 | 0.0024 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.013 | 0.2637 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0494 | 0.0494 |
Entamoeba histolytica | hypothetical protein | 0.042 | 0.345 | 0.345 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0494 | 0.0494 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0494 | 0.0494 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0024 | 0.0024 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.013 | 0.0075 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0024 | 0.0024 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0003 | 0.0003 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.1211 | 1 | 1 |
Entamoeba histolytica | deoxycytidine triphosphate deaminase, putative | 0.042 | 0.345 | 0.345 |
Mycobacterium ulcerans | deoxycytidine triphosphate deaminase | 0.042 | 0.345 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0494 | 0.1096 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0723 | 0.5956 | 0.5956 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0024 | 0.0024 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0011 | 0.0055 | 0.1117 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.013 | 0.013 |
Echinococcus granulosus | expressed protein | 0.0035 | 0.0257 | 0.0257 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0024 | 0.0024 |
Toxoplasma gondii | PPIC-type PPIASE domain-containing protein | 0.0011 | 0.0055 | 0.0055 |
Trichomonas vaginalis | rotamase, putative | 0.0035 | 0.0257 | 0.0257 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0517 | 0.0517 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.1211 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.013 | 0.013 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.023 | 0.023 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0024 | 0.0024 |
Schistosoma mansoni | hypothetical protein | 0.0428 | 0.3517 | 0.3517 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0216 | 0.0216 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0517 | 0.0517 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.013 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0517 | 0.0517 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.013 | 0.0378 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0024 | 0.0024 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0035 | 0.0257 | 0.0257 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0723 | 0.5956 | 0.5956 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0517 | 0.0517 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0024 | 0.0024 |
Entamoeba histolytica | hypothetical protein | 0.0791 | 0.6517 | 0.6517 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0024 | 0.0024 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0723 | 0.5956 | 0.5956 |
Mycobacterium ulcerans | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.042 | 0.345 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0034 | 0.025 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0044 | 0.0044 |
Onchocerca volvulus | 0.003 | 0.0216 | 1 | |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0043 | 0.0043 |
Entamoeba histolytica | hypothetical protein | 0.0791 | 0.6517 | 0.6517 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0024 | 0.0024 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0024 | 0.0024 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0034 | 0.025 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0044 | 0.0044 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.013 | 0.5209 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.1211 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.1211 | 1 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.1211 | 1 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.1211 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0216 | 0.0216 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.013 | 0.013 |
Echinococcus multilocularis | expressed protein | 0.0035 | 0.0257 | 0.0257 |
Entamoeba histolytica | hypothetical protein | 0.1211 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0034 | 0.025 | 0.025 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.023 | 0.023 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.013 | 0.5209 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0034 | 0.025 | 0.5063 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.013 | 0.013 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0517 | 0.0517 |
Trichomonas vaginalis | rotamase, putative | 0.0034 | 0.025 | 0.025 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.023 | 0.023 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0024 | 0.0024 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.1211 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0494 | 0.0494 |
Wolbachia endosymbiont of Brugia malayi | deoxycytidine triphosphate deaminase | 0.042 | 0.345 | 0.3414 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0517 | 0.0517 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0428 | 0.3517 | 0.3517 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.1211 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.013 | 0.013 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0517 | 0.0517 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0024 | 0.0024 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.023 | 0.023 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0494 | 0.1096 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0517 | 0.0517 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0494 | 0.1096 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0024 | 0.0024 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.1211 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0494 | 0.0494 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0064 | 0.0496 | 0.0496 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0517 | 0.0517 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0024 | 0.0024 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0024 | 0.0024 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.1211 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.1211 | 1 | 1 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.1211 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0024 | 0.0024 |
Schistosoma mansoni | rotamase | 0.0035 | 0.0257 | 0.0257 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.0439 | 0.0439 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, putative | 0.042 | 0.345 | 0.345 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.013 | 0.013 |
Mycobacterium leprae | PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) | 0.042 | 0.345 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.013 | 0.5209 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.1211 | 1 | 1 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.1211 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.813 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.77 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.756 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.716 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.711 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.69 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.666 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.635 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.578 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.