Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutaredoxin protein 5 | 0.093 | 0.1315 | 0.1315 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0169 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0166 | 0.0166 |
Echinococcus granulosus | neuroglian | 0.0127 | 0.0103 | 0.0103 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0485 | 0.0643 | 0.0643 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0981 | 0.1393 | 0.6315 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0485 | 0.0643 | 0.0643 |
Echinococcus granulosus | protein kinase C gamma type | 0.0485 | 0.0643 | 0.0643 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.094 | 0.1331 | 0.1331 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0981 | 0.1393 | 0.1393 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0485 | 0.0643 | 0.0643 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0485 | 0.0643 | 0.0643 |
Brugia malayi | Hr1 repeat family protein | 0.0485 | 0.0643 | 0.163 |
Trichomonas vaginalis | AGC family protein kinase | 0.1456 | 0.2109 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0485 | 0.0643 | 0.0643 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0169 | 0.0166 | 0.0166 |
Echinococcus multilocularis | neuroglian | 0.0127 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.2673 | 0.3947 | 0.3947 |
Brugia malayi | protein kinase C II. | 0.0485 | 0.0643 | 0.163 |
Echinococcus multilocularis | protein kinase c iota type | 0.0485 | 0.0643 | 0.0643 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.093 | 0.1315 | 0.1315 |
Entamoeba histolytica | protein kinase, putative | 0.1456 | 0.2109 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0485 | 0.0643 | 0.0643 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0981 | 0.1393 | 0.6315 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0166 | 0.0166 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0485 | 0.0643 | 0.0643 |
Brugia malayi | Protein kinase domain containing protein | 0.1456 | 0.2109 | 0.5343 |
Echinococcus granulosus | Immunoglobulin | 0.0101 | 0.0064 | 0.0064 |
Echinococcus granulosus | roundabout 2 | 0.016 | 0.0152 | 0.0152 |
Brugia malayi | Protein kinase domain containing protein | 0.0485 | 0.0643 | 0.163 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0981 | 0.1393 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.1641 | 0.2389 | 0.2389 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0485 | 0.0643 | 0.0643 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0485 | 0.0643 | 0.0643 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0169 | 0.0166 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.1456 | 0.2109 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0526 | 0.0705 | 0.2775 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0064 | 0.0162 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.094 | 0.1331 | 0.1331 |
Echinococcus granulosus | NDR protein kinase | 0.0485 | 0.0643 | 0.0643 |
Trichomonas vaginalis | AGC family protein kinase | 0.0485 | 0.0643 | 0.2456 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0981 | 0.1393 | 0.1393 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0485 | 0.0643 | 0.0643 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0485 | 0.0643 | 0.0643 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0485 | 0.0643 | 0.0643 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0485 | 0.0643 | 0.0643 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.1456 | 0.2109 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1179 | 0.1691 | 0.7848 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0101 | 0.0064 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0064 | 0.0064 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0485 | 0.0643 | 0.0643 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.094 | 0.1331 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0134 | 0.0114 | 0.0114 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0169 | 0.0166 | 0.0166 |
Echinococcus multilocularis | nervana 2 | 0.093 | 0.1315 | 0.1315 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0169 | 0.0166 | 0.0746 |
Trichomonas vaginalis | AGC family protein kinase | 0.1456 | 0.2109 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1456 | 0.2109 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0485 | 0.0643 | 0.0643 |
Echinococcus multilocularis | sodium calcium exchanger | 0.6682 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0485 | 0.0643 | 0.0643 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0981 | 0.1393 | 0.1393 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0981 | 0.1393 | 0.1393 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0485 | 0.0643 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0064 | 0.0064 |
Entamoeba histolytica | protein kinase 2, putative | 0.094 | 0.1331 | 0.5995 |
Schistosoma mansoni | sodium/calcium exchanger | 0.6682 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.094 | 0.1331 | 0.1331 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0166 | 0.0166 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0101 | 0.0064 | 0.0064 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0169 | 0.0166 | 0.0421 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0485 | 0.0643 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0114 | 0.0114 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0101 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0485 | 0.0643 | 0.0643 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0014 | 0.0014 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0485 | 0.0643 | 0.0643 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0485 | 0.0643 | 0.0643 |
Echinococcus granulosus | nervana 2 | 0.093 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0069 | 0.0016 | 0.0016 |
Trichomonas vaginalis | AGC family protein kinase | 0.1456 | 0.2109 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.094 | 0.1331 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.016 | 0.0152 | 0.0152 |
Entamoeba histolytica | protein kinase, putative | 0.1414 | 0.2047 | 0.9681 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1179 | 0.1691 | 0.7848 |
Treponema pallidum | hypothetical protein | 0.0169 | 0.0166 | 0.5 |
Giardia lamblia | Kinase, AGC PKA | 0.094 | 0.1331 | 0.5 |
Schistosoma mansoni | serine/threonine kinase | 0.0485 | 0.0643 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.0643 | 0.0643 |
Trichomonas vaginalis | AGC family protein kinase | 0.1456 | 0.2109 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0485 | 0.0643 | 0.0643 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.1641 | 0.2389 | 0.6054 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0152 | 0.0152 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.093 | 0.1315 | 0.1315 |
Brugia malayi | Sodium/calcium exchanger protein | 0.2673 | 0.3947 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0169 | 0.0166 | 0.0166 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.093 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0169 | 0.0166 | 0.0166 |
Echinococcus granulosus | protein kinase c iota type | 0.0485 | 0.0643 | 0.0643 |
Schistosoma mansoni | vesicular amine transporter | 0.0101 | 0.0064 | 0.0064 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0485 | 0.0643 | 0.0643 |
Loa Loa (eye worm) | solute carrier family 8 | 0.6682 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.1414 | 0.2047 | 0.2047 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0485 | 0.0643 | 0.0643 |
Trichomonas vaginalis | AGC family protein kinase | 0.0485 | 0.0643 | 0.2456 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0152 | 0.0152 |
Schistosoma mansoni | nephrin | 0.0127 | 0.0103 | 0.0103 |
Echinococcus multilocularis | Immunoglobulin | 0.0101 | 0.0064 | 0.0064 |
Echinococcus multilocularis | Immunoglobulin | 0.0101 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0064 | 0.0064 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0485 | 0.0643 | 0.0643 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0169 | 0.0166 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0134 | 0.0114 | 0.0114 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0101 | 0.0064 | 0.0162 |
Echinococcus granulosus | nervana 2 | 0.093 | 0.1315 | 0.1315 |
Trichomonas vaginalis | AGC family protein kinase | 0.0485 | 0.0643 | 0.2456 |
Echinococcus granulosus | defective proboscis extension response | 0.0101 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.1456 | 0.2109 | 0.2109 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.1414 | 0.2047 | 0.5186 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0101 | 0.0064 | 0.0064 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0169 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0064 | 0.0064 |
Onchocerca volvulus | 0.1498 | 0.2173 | 0.9763 | |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0166 | 0.0166 |
Schistosoma mansoni | atypical protein kinase C | 0.0485 | 0.0643 | 0.0643 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0485 | 0.0643 | 0.0643 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0169 | 0.0166 | 0.0166 |
Entamoeba histolytica | protein kinase, putative | 0.0485 | 0.0643 | 0.2456 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0169 | 0.0166 | 0.0421 |
Trichomonas vaginalis | AGC family protein kinase | 0.1456 | 0.2109 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0485 | 0.0643 | 0.0643 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0485 | 0.0643 | 0.0643 |
Echinococcus multilocularis | nervana 2 | 0.093 | 0.1315 | 0.1315 |
Schistosoma mansoni | na/ca exchanger | 0.0169 | 0.0166 | 0.0166 |
Trypanosoma cruzi | Protein kinase B | 0.0981 | 0.1393 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1456 | 0.2109 | 1 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0474 | 0.0627 | 0.2375 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.1533 | 0.2226 | 1 |
Toxoplasma gondii | AGC kinase | 0.1414 | 0.2047 | 1 |
Echinococcus granulosus | twitchin | 0.0137 | 0.0119 | 0.0119 |
Brugia malayi | Protein kinase domain containing protein | 0.0485 | 0.0643 | 0.163 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.