Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | choline o-acyltransferase | 0.0254 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0254 | 0 | 0.5 |
Onchocerca volvulus | 0.0254 | 0 | 0.5 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0254 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2648 | 1 | 1 |
Onchocerca volvulus | 0.0254 | 0 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1382 | 0.4715 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1382 | 0.4715 | 1 |
Onchocerca volvulus | 0.0254 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1382 | 0.4715 | 1 |
Onchocerca volvulus | 0.0254 | 0 | 0.5 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1382 | 0.4715 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0254 | 0 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1382 | 0.4715 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0254 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 32 ug ml-1 | Antifungal activity against Candida albicans ATCC 26790 | ChEMBL. | 11429991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.