Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0204 | 0.0497 | 0.0545 |
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.02 | 0.0479 | 0.9648 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0204 | 0.0497 | 0.0545 |
Schistosoma mansoni | protein kinase | 0.0204 | 0.0497 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0204 | 0.0497 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0204 | 0.0497 | 0.0545 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0204 | 0.0497 | 0.0545 |
Brugia malayi | Protein kinase domain | 0.0204 | 0.0497 | 0.0497 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0204 | 0.0497 | 0.0545 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.0479 | 0.9648 |
Trichomonas vaginalis | STE family protein kinase | 0.0204 | 0.0497 | 1 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.02 | 0.0479 | 0.0479 |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.02 | 0.0479 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.0479 | 0.0479 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.02 | 0.0479 | 0.0479 |
Entamoeba histolytica | protein kinase, putative | 0.0204 | 0.0497 | 1 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.02 | 0.0479 | 0.0526 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.0479 | 0.9648 |
Brugia malayi | WH1 domain containing protein | 0.02 | 0.0479 | 0.0479 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.02 | 0.0479 | 0.0526 |
Schistosoma mansoni | protein kinase | 0.02 | 0.0479 | 0.9648 |
Schistosoma mansoni | protein kinase | 0.0204 | 0.0497 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0204 | 0.0497 | 1 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.02 | 0.0479 | 0.0479 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.2143 | 0.9112 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0204 | 0.0497 | 0.0545 |
Entamoeba histolytica | p21-activated kinase | 0.0204 | 0.0497 | 1 |
Schistosoma mansoni | protein kinase | 0.0204 | 0.0497 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0204 | 0.0497 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.2343 | 1 | 1 |
Echinococcus multilocularis | neural Wiskott Aldrich syndrome protein | 0.02 | 0.0479 | 0.0526 |
Entamoeba histolytica | protein kinase, putative | 0.0204 | 0.0497 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0092 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0204 | 0.0497 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.2143 | 0.9112 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0204 | 0.0497 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0204 | 0.0497 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0204 | 0.0497 | 0.0545 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.02 | 0.0479 | 0.9648 |
Trichomonas vaginalis | STE family protein kinase | 0.0204 | 0.0497 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.02 | 0.0479 | 0.9648 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.0479 | 0.9648 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.02 | 0.0479 | 0.0526 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0092 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.275 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.909 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.657 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.641 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.481 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.476 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.297 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.