Detailed information for compound 1610282

Basic information

Technical information
  • TDR Targets ID: 1610282
  • Name: (5Z)-3-[(2-chloro-6-methylquinolin-3-yl)methy lideneamino]-5-[(3-nitrophenyl)methylidene]-2 -phenylimidazol-4-one
  • MW: 495.917 | Formula: C27H18ClN5O3
  • H donors: 0 H acceptors: 4 LogP: 6.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)cc(c(n2)Cl)/C=N/N1C(=N/C(=C\c2cccc(c2)[N+](=O)[O-])/C1=O)c1ccccc1
  • InChi: 1S/C27H18ClN5O3/c1-17-10-11-23-20(12-17)15-21(25(28)30-23)16-29-32-26(19-7-3-2-4-8-19)31-24(27(32)34)14-18-6-5-9-22(13-18)33(35)36/h2-16H,1H3/b24-14-,29-16+
  • InChiKey: CLVKDVCKGHENDD-JHTRWWIWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(2-chloro-6-methylquinolin-3-yl)methylideneamino]-5-[(3-nitrophenyl)methylidene]-2-phenylimidazol-4-one
  • (5Z)-3-[(2-chloro-6-methyl-3-quinolyl)methyleneamino]-5-[(3-nitrophenyl)methylene]-2-phenyl-imidazol-4-one
  • 3-[(2-chloro-6-methyl-3-quinolyl)methyleneamino]-5-[(3-nitrophenyl)methylene]-2-phenyl-imidazol-4-one
  • (5Z)-3-[(2-chloro-6-methyl-3-quinolyl)methyleneamino]-5-[(3-nitrophenyl)methylene]-2-phenyl-4-imidazolone
  • 3-[(2-chloro-6-methyl-3-quinolyl)methyleneamino]-5-[(3-nitrophenyl)methylene]-2-phenyl-4-imidazolone
  • 3-[(2-chloro-6-methyl-3-quinolyl)methyleneamino]-5-(3-nitrobenzylidene)-2-phenyl-imidazol-4-one
  • (5Z)-3-[(2-chloro-6-methyl-3-quinolyl)methyleneamino]-5-(3-nitrobenzylidene)-2-phenyl-imidazol-4-one
  • 3-[(2-chloro-6-methyl-quinolin-3-yl)methylideneamino]-5-[(3-nitrophenyl)methylidene]-2-phenyl-imidazol-4-one
  • (5Z)-3-[(2-chloro-6-methyl-quinolin-3-yl)methylideneamino]-5-[(3-nitrophenyl)methylidene]-2-phenyl-imidazol-4-one
  • NCI60_039270
  • NSC711897

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ORL1-like opioid receptor 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0109 0.215 0.2228
Echinococcus granulosus g protein coupled receptor 0.0109 0.215 0.2228
Schistosoma mansoni growth hormone secretagogue receptor 0.0109 0.215 0.5792
Echinococcus granulosus biogenic amine 5HT receptor 0.0109 0.215 0.2228
Schistosoma mansoni hypothetical protein 0.0036 0.0279 0.0752
Schistosoma mansoni amine GPCR 0.0109 0.215 0.5792
Echinococcus granulosus fmrfamide receptor 0.0109 0.215 0.2228
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.215 0.2228
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0156 0.3348 0.324
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.215 0.2023
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0051 0.0668 0.0516
Brugia malayi G-protein coupled receptor 0.0109 0.215 0.2023
Echinococcus multilocularis somatostatin receptor 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0109 0.215 0.2228
Brugia malayi cell division control protein 2 homolog 0.0051 0.0668 0.0516
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.215 0.2228
Echinococcus granulosus g-protein coupled receptor 0.0109 0.215 0.2228
Onchocerca volvulus 0.0109 0.215 0.5
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0668 0.5
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Trypanosoma brucei cdc2-related kinase 1 0.0051 0.0668 0.5
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0668 0.0569
Schistosoma mansoni histamine h1 receptor 0.0109 0.215 0.5792
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0109 0.215 0.2023
Echinococcus granulosus g protein coupled receptor 0.0109 0.215 0.2228
Onchocerca volvulus 0.0109 0.215 0.5
Entamoeba histolytica protein kinase, putative 0.0037 0.0311 0.081
Schistosoma mansoni myosin xvIII 0.0109 0.215 0.5792
Brugia malayi sulfakinin receptor protein 0.0109 0.215 0.2023
Echinococcus multilocularis neuropeptide receptor A26 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0668 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.215 0.5792
Loa Loa (eye worm) hypothetical protein 0.0135 0.2823 0.2706
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.215 0.2228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.215 0.5792
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0109 0.215 0.5792
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0109 0.215 0.2228
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0668 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0156 0.3348 0.3568
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0037 0.0311 0.0169
Echinococcus granulosus alpha 1A adrenergic receptor 0.0109 0.215 0.2228
Onchocerca volvulus 0.0109 0.215 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.215 0.2228
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0037 0.0311 0.0169
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0109 0.215 0.2023
Echinococcus granulosus PAK box P21 Rho binding 0.0036 0.0279 0.0134
Echinococcus multilocularis serotonin receptor 0.0109 0.215 0.2228
Entamoeba histolytica protein kinase, putative 0.0037 0.0311 0.081
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus multilocularis g protein coupled receptor 0.0109 0.215 0.2228
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.215 0.2228
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0109 0.215 0.5792
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.215 0.2228
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0109 0.215 0.2023
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.215 0.2228
Brugia malayi G-protein coupled receptor 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni neuropeptide receptor 0.0109 0.215 0.5792
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.215 0.5792
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.215 0.2228
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0109 0.215 0.2228
Echinococcus granulosus voltage gated potassium channel 0.0045 0.0525 0.0409
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi Dopamine receptor protein 2 0.0109 0.215 0.2023
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0146 0.3086 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.215 0.5792
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.215 0.5792
Echinococcus multilocularis PAK box P21 Rho binding 0.0037 0.0311 0.0169
Schistosoma mansoni amine GPCR 0.0109 0.215 0.5792
Schistosoma mansoni hypothetical protein 0.0109 0.215 0.5792
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0036 0.0279 0.0134
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.215 0.2228
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.215 0.5792
Schistosoma mansoni neuropeptide f receptor 76f 0.0109 0.215 0.5792
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0668 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0045 0.0525 0.0371
Entamoeba histolytica protein kinase, putative 0.0037 0.0311 0.081
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0525 0.1414
Echinococcus multilocularis neuropeptide receptor 0.0109 0.215 0.2228
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0156 0.3348 0.324
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.215 0.2023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.215 0.5792
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0156 0.3348 0.3568
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0109 0.215 0.2023
Echinococcus granulosus dro:myosuppressin receptor 0.0109 0.215 0.2228
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.215 0.2228
Echinococcus granulosus neuropeptide receptor A26 0.0109 0.215 0.2228
Echinococcus granulosus 7tm_1 domain containing protein 0.0109 0.215 0.2228
Echinococcus multilocularis G protein coupled receptor 139 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0109 0.215 0.5792
Schistosoma mansoni hypothetical protein 0.0036 0.0279 0.0752
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0051 0.0668 0.0569
Onchocerca volvulus 0.0109 0.215 0.5
Brugia malayi AKH receptor 0.0109 0.215 0.2023
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0109 0.215 0.5792
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0668 0.1737
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi RE15519p 0.0109 0.215 0.2023
Schistosoma mansoni opsin-like receptor 0.0109 0.215 0.5792
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Echinococcus granulosus somatostatin receptor 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0036 0.0279 0.0121
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.215 0.5792
Schistosoma mansoni hypothetical protein 0.0109 0.215 0.5792
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0668 1
Brugia malayi GnHR receptor homolog 0.0109 0.215 0.2023
Brugia malayi Tachykinin-like peptides receptor 99D 0.0109 0.215 0.2023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.215 0.2228
Brugia malayi putative neuropeptide receptor 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus granulosus neuropeptide FF receptor 2 0.0109 0.215 0.2228
Echinococcus granulosus tachykinin peptides receptor 99D 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni biogenic amine receptor 0.0109 0.215 0.5792
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus multilocularis g protein coupled receptor 0.0109 0.215 0.2228
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0051 0.0668 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0109 0.215 0.2023
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.215 0.2228
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0668 0.0516
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0109 0.215 0.2228
Echinococcus multilocularis allatostatin A receptor 0.0109 0.215 0.2228
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.215 0.2228
Onchocerca volvulus 0.0109 0.215 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.215 0.2228
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.215 0.2228
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0279 0.0408
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0668 0.1737
Brugia malayi Melatonin receptor type 1A 0.0109 0.215 0.2023
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.016 0.043
Echinococcus granulosus serotonin receptor 0.0109 0.215 0.2228
Echinococcus granulosus cyclin dependent kinase 0.0051 0.0668 0.0569
Echinococcus multilocularis voltage gated potassium channel 0.0045 0.0525 0.0409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.215 0.5792
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0109 0.215 0.2023
Echinococcus multilocularis PAK box P21 Rho binding 0.0036 0.0279 0.0134
Trichomonas vaginalis STE family protein kinase 0.0037 0.0311 0.0516
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi Dopamine receptor 0.0109 0.215 0.2023
Onchocerca volvulus Neuropeptide F receptor homolog 0.0109 0.215 0.5
Echinococcus granulosus allatostatin A receptor 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus multilocularis g protein coupled receptor 0.0109 0.215 0.2228
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0109 0.215 0.2228
Schistosoma mansoni amine GPCR 0.0109 0.215 0.5792
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.215 0.2023
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0668 0.0516
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.215 0.2228
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0109 0.215 0.5792
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0109 0.215 0.2228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0051 0.0668 0.5
Echinococcus multilocularis fmrfamide receptor 0.0109 0.215 0.2228
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.215 0.5792
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0036 0.0279 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0668 0.1799
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0036 0.0279 0.0752
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0381 0.9094 1
Brugia malayi Dopamine receptor protein 1 0.0109 0.215 0.2023
Echinococcus granulosus G protein coupled receptor 139 0.0109 0.215 0.2228
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0417 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.215 0.2228
Schistosoma mansoni opsin-like receptor 0.0109 0.215 0.5792
Schistosoma mansoni amine GPCR 0.0109 0.215 0.5792
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.215 0.2228
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0036 0.0279 0.0134
Echinococcus multilocularis neuropeptide s receptor 0.0109 0.215 0.2228
Echinococcus multilocularis neuropeptide receptor 0.0109 0.215 0.2228
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.215 0.5792
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.016 0.043
Echinococcus multilocularis dro:myosuppressin receptor 0.0109 0.215 0.2228
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0037 0.0311 0.0169
Schistosoma mansoni protein kinase 0.0036 0.0279 0.0752
Brugia malayi Protein kinase domain containing protein 0.0051 0.0668 0.0516
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0109 0.215 0.2023
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.215 0.2228
Onchocerca volvulus 0.0109 0.215 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0109 0.215 0.2228
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0146 0.3086 1
Echinococcus multilocularis fmrfamide receptor 0.0109 0.215 0.2228
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0051 0.0668 0.5
Echinococcus granulosus sex peptide receptor 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi neuropeptide F receptor 0.0109 0.215 0.2023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.215 0.2228
Brugia malayi WH1 domain containing protein 0.0036 0.0279 0.0121
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.215 0.5792
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0037 0.0311 0.0169
Schistosoma mansoni biogenic amine (5HT) receptor 0.0109 0.215 0.5792
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0109 0.215 0.2023
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0109 0.215 0.5792
Schistosoma mansoni biogenic amine (5HT) receptor 0.0109 0.215 0.5792
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0109 0.215 0.2228
Schistosoma mansoni amine GPCR 0.0109 0.215 0.5792
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.215 0.2228
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.215 0.5792
Echinococcus multilocularis cyclin dependent kinase 5 0.0051 0.0668 0.0569
Schistosoma mansoni protein kinase 0.0037 0.0311 0.0837
Echinococcus granulosus neuropeptide s receptor 0.0109 0.215 0.2228
Brugia malayi neuropeptide F receptor 0.0109 0.215 0.2023
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0045 0.0525 0.0371
Schistosoma mansoni adenoreceptor 0.0109 0.215 0.5792
Brugia malayi Serotonin receptor 0.0109 0.215 0.2023
Trypanosoma brucei cdc2-related kinase 3 0.0051 0.0668 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0109 0.215 0.2023
Echinococcus granulosus peptide allatostatin:somatostatin 0.0109 0.215 0.2228
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0668 0.5
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0668 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.005 0.0636 0.0484
Entamoeba histolytica p21-activated kinase 0.0037 0.0311 0.081
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi follicle stimulating hormone receptor 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0525 0.0409
Brugia malayi P21-Rho-binding domain containing protein 0.0036 0.0279 0.0121
Onchocerca volvulus 0.0109 0.215 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.215 0.2228
Schistosoma mansoni protein kinase 0.0037 0.0311 0.0837
Brugia malayi P21-Rho-binding domain containing protein 0.0036 0.0279 0.0121
Schistosoma mansoni tyrosine kinase 0.0036 0.0279 0.0752
Schistosoma mansoni voltage-gated potassium channel 0.017 0.3713 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0037 0.0311 0.0169
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.016 0.043
Schistosoma mansoni neuropeptide receptor 0.0109 0.215 0.5792
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.215 0.5792
Plasmodium vivax protein kinase Crk2 0.0051 0.0668 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Entamoeba histolytica protein kinase, putative 0.0037 0.0311 0.081
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0109 0.215 0.2228
Echinococcus multilocularis sex peptide receptor 0.0109 0.215 0.2228
Brugia malayi Serotonin receptor 0.0109 0.215 0.2023
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.215 0.5792
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0279 0.0752
Echinococcus granulosus g protein coupled receptor 0.0109 0.215 0.2228
Schistosoma mansoni alpha-1 adrenergic receptor 0.0109 0.215 0.5792
Brugia malayi G protein-coupled receptor 0.0109 0.215 0.2023
Echinococcus multilocularis G-protein coupled receptor, putative 0.0109 0.215 0.2228
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0037 0.0311 0.0169
Echinococcus granulosus neuropeptide receptor 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni biogenic amine receptor 0.0109 0.215 0.5792
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0036 0.0279 0.0121
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0525 0.0409
Schistosoma mansoni hypothetical protein 0.0109 0.215 0.5792
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.215 0.2228
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0109 0.215 0.2023
Echinococcus granulosus cyclin dependent kinase 1 0.0051 0.0668 0.0569
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.016 0.043
Schistosoma mansoni hypothetical protein 0.0109 0.215 0.5792
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni hypothetical protein 0.0036 0.0279 0.0752
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.215 0.2228
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.215 0.2228
Loa Loa (eye worm) TYRA-2 protein 0.0109 0.215 0.2023
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0525 0.1414
Brugia malayi hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.016 0.043
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0668 0.1737
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0109 0.215 0.5792
Trichomonas vaginalis STE family protein kinase 0.0037 0.0311 0.0516
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni neuropeptide receptor 0.0109 0.215 0.5792
Echinococcus multilocularis cyclin dependent kinase 0.0051 0.0668 0.0569
Echinococcus granulosus neuropeptide receptor 0.0109 0.215 0.2228
Echinococcus multilocularis orexin receptor type 2 0.0109 0.215 0.2228
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0109 0.215 0.5
Trichomonas vaginalis STE family protein kinase 0.0037 0.0311 0.0516
Echinococcus multilocularis serotonin receptor 0.0109 0.215 0.2228
Schistosoma mansoni protein kinase 0.0037 0.0311 0.0837
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0109 0.215 0.2228
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0109 0.215 0.2228
Echinococcus granulosus orexin receptor type 2 0.0109 0.215 0.2228
Schistosoma mansoni neuropeptide receptor 0.0109 0.215 0.5792
Schistosoma mansoni biogenic amine receptor 0.0109 0.215 0.5792
Brugia malayi Protein kinase domain 0.0037 0.0311 0.0153
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0668 0.1799
Echinococcus multilocularis g-protein coupled receptor 0.0109 0.215 0.2228
Echinococcus granulosus hypothetical protein 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Trichomonas vaginalis STE family protein kinase 0.0037 0.0311 0.0516
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Echinococcus granulosus cyclin dependent kinase 5 0.0051 0.0668 0.0569
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.215 0.2228
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Onchocerca volvulus 0.0109 0.215 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0109 0.215 0.5792
Plasmodium falciparum protein kinase 5 0.0051 0.0668 0.5
Trichomonas vaginalis STE family protein kinase 0.0037 0.0311 0.0516
Schistosoma mansoni voltage-gated potassium channel 0.017 0.3713 1
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0381 0.9094 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Schistosoma mansoni opsin-like receptor 0.0109 0.215 0.5792
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0109 0.215 0.2023
Brugia malayi larval opioid receptor 0.0109 0.215 0.2023
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0668 0.0569
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.215 0.5792
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.215 0.2228
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0109 0.215 0.2228
Brugia malayi putative neuropeptide receptor NPR1 0.0109 0.215 0.2023
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.016 0.043
Loa Loa (eye worm) hypothetical protein 0.0109 0.215 0.2023

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.69 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.447 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.42 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.407 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.334 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.309 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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