Detailed information for compound 161044

Basic information

Technical information
  • TDR Targets ID: 161044
  • Name: azane; cyclobutane-1,1-dicarboxylic acid; pla tinum(2+)
  • MW: 373.264 | Formula: C6H14N2O4Pt++
  • H donors: 2 H acceptors: 2 LogP: -0.47 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1O[Pt]OC(=O)C21CCC2.[NH4+].[NH4+]
  • InChi: 1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2
  • InChiKey: OLESAACUTLOWQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ammonia; cyclobutane-1,1-dicarboxylic acid; platinum(2+)
  • Carboplatin
  • azane; cyclobutane-1,1-dicarboxylic acid; platinum(+2) cation
  • ammonia; cyclobutane-1,1-dicarboxylic acid; platinum(+2) cation
  • 41575-94-4
  • 70903-55-8
  • EU-0100230
  • (SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
  • CHEBI:31355
  • CCRIS 3404
  • Carboplatin [USAN:BAN:INN:JAN]
  • Carboplatine [French]
  • Carboplatino [Spanish]
  • Carboplatinum [Latin]
  • Cbdca
  • Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
  • Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
  • Diammine-1,1-cyclobutane dicarboxylate platinum II
  • EINECS 255-446-0
  • HSDB 6957
  • JM 8
  • NSC 201345
  • NSC 241240
  • NSC-241240
  • Paraplatin
  • Platinum (II), (1,1-cyclobutanedicarboxylato)diammine-, cis-
  • Platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2)-
  • Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
  • cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
  • cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
  • cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus carbonic anhydrase II 0.0234 0.6747 0.6747
Schistosoma mansoni biogenic amine receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0129 0.331 0.4879
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Brugia malayi G protein-coupled receptor F59B2.13 0.0129 0.331 0.4879
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0185 0.512 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.331 0.3286
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0185 0.512 0.7566
Echinococcus multilocularis neuropeptide receptor 0.0129 0.331 0.3286
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.331 0.4879
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0129 0.331 0.4879
Plasmodium vivax SET domain protein, putative 0.0029 0.0036 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.331 0.4879
Schistosoma mansoni opsin-like receptor 0.0129 0.331 0.4879
Echinococcus granulosus tachykinin peptides receptor 99D 0.0129 0.331 0.331
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0593 0.0593
Schistosoma mansoni hypothetical protein 0.0167 0.4551 0.6729
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.011 0.011
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.331 0.3286
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni amine GPCR 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus multilocularis neuropeptide FF receptor 2 0.0129 0.331 0.3286
Echinococcus multilocularis carbonic anhydrase 0.0127 0.3227 0.3203
Echinococcus granulosus serotonin receptor 0.0129 0.331 0.331
Brugia malayi putative neuropeptide receptor NPR1 0.0129 0.331 0.4879
Onchocerca volvulus Huntingtin homolog 0.0121 0.3033 0.4476
Schistosoma mansoni myosin xvIII 0.0129 0.331 0.4879
Schistosoma mansoni neuropeptide f receptor 76f 0.0129 0.331 0.4879
Echinococcus multilocularis neuropeptides capa receptor 0.0129 0.331 0.3286
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.331 0.331
Onchocerca volvulus Huntingtin homolog 0.0121 0.3033 0.4476
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0129 0.331 0.4879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.331 0.3286
Brugia malayi hypothetical protein 0.0121 0.3033 0.4466
Echinococcus multilocularis g protein coupled receptor 0.0129 0.331 0.3286
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.011 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0129 0.331 0.331
Echinococcus granulosus sex peptide receptor 0.0129 0.331 0.331
Echinococcus granulosus fmrfamide receptor 0.0129 0.331 0.331
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0049 0.067 0.0945
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.011 0.0112
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0127 0.3227 0.4756
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.331 0.4879
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.331 0.331
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0161 0.4329 0.6397
Loa Loa (eye worm) hypothetical protein 0.0032 0.011 0.0112
Onchocerca volvulus 0.0129 0.331 0.4889
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Onchocerca volvulus 0.0185 0.512 0.7593
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.011 0.0112
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0049 0.0682 0.0964
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0129 0.331 0.331
Brugia malayi Dopamine receptor protein 2 0.0129 0.331 0.4879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.331 0.4879
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0129 0.331 0.3286
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Brugia malayi Muscleblind-like protein 0.0148 0.3902 0.5761
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.011 0.0075
Echinococcus multilocularis geminin 0.0167 0.4551 0.4532
Echinococcus multilocularis muscleblind protein 1 0.0148 0.3902 0.388
Loa Loa (eye worm) hypothetical protein 0.0121 0.3033 0.4466
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.011 0.0075
Echinococcus multilocularis orexin receptor type 2 0.0129 0.331 0.3286
Echinococcus granulosus neuropeptide s receptor 0.0129 0.331 0.331
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0234 0.6747 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0129 0.331 0.4879
Brugia malayi G-protein coupled receptor 0.0129 0.331 0.4879
Echinococcus granulosus tm gpcr rhodopsin 0.0129 0.331 0.331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.331 0.3286
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0185 0.512 0.7577
Echinococcus granulosus geminin 0.0167 0.4551 0.4551
Schistosoma mansoni neuropeptide F-like receptor 0.0129 0.331 0.4879
Toxoplasma gondii hypothetical protein 0.0127 0.3227 1
Echinococcus granulosus tm gpcr rhodopsin 0.0129 0.331 0.331
Echinococcus multilocularis g protein coupled receptor 0.0129 0.331 0.3286
Echinococcus granulosus carbonic anhydrase 0.0127 0.3227 0.3227
Echinococcus granulosus neuropeptide Y receptor 0.0129 0.331 0.331
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus multilocularis somatostatin receptor 0.0129 0.331 0.3286
Schistosoma mansoni amine GPCR 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Onchocerca volvulus Neuropeptide F receptor homolog 0.0129 0.331 0.4889
Schistosoma mansoni hypothetical protein 0.0036 0.0234 0.0295
Loa Loa (eye worm) G-protein coupled receptor 0.0129 0.331 0.4879
Schistosoma mansoni carbonic anhydrase 0.0127 0.3227 0.4756
Brugia malayi sulfakinin receptor protein 0.0129 0.331 0.4879
Brugia malayi larval opioid receptor 0.0129 0.331 0.4879
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0129 0.331 0.4879
Echinococcus granulosus neuropeptides capa receptor 0.0129 0.331 0.331
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0127 0.3227 0.4756
Onchocerca volvulus 0.0234 0.6732 1
Echinococcus multilocularis sex peptide receptor 0.0129 0.331 0.3286
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0234 0.0199
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) carbonic anhydrase 3 0.0234 0.6747 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0185 0.512 0.7566
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.011 0.0112
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) neuropeptide F receptor 0.0129 0.331 0.4879
Schistosoma mansoni biogenic amine receptor 0.0129 0.331 0.4879
Onchocerca volvulus 0.0129 0.331 0.4889
Schistosoma mansoni hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.011 0.011
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0185 0.512 0.7566
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0129 0.331 0.3286
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0129 0.331 0.331
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0185 0.512 0.7566
Schistosoma mansoni biogenic amine (5HT) receptor 0.0129 0.331 0.4879
Schistosoma mansoni amine GPCR 0.0129 0.331 0.4879
Echinococcus granulosus peptide allatostatin:somatostatin 0.0129 0.331 0.331
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0129 0.331 0.3286
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0172 0.0204
Onchocerca volvulus 0.0049 0.067 0.0947
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127 0.3227 0.4756
Echinococcus granulosus alpha 1A adrenergic receptor 0.0129 0.331 0.331
Onchocerca volvulus 0.0129 0.331 0.4889
Onchocerca volvulus 0.0129 0.331 0.4889
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.331 0.331
Schistosoma mansoni neuropeptide receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0148 0.3902 0.5761
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0129 0.331 0.3286
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.011 0.0112
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni carbonic anhydrase-related 0.0127 0.3227 0.4756
Loa Loa (eye worm) neuropeptide F receptor 0.0129 0.331 0.4879
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.331 0.331
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni hypothetical protein 0.0129 0.331 0.4879
Brugia malayi Pre-SET motif family protein 0.0206 0.5802 0.8593
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.5802 0.8593
Onchocerca volvulus 0.0129 0.331 0.4889
Echinococcus granulosus dro:myosuppressin receptor 0.0129 0.331 0.331
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni adenoreceptor 0.0129 0.331 0.4879
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.011 0.0112
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0129 0.331 0.4879
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0129 0.331 0.4879
Onchocerca volvulus 0.0129 0.331 0.4889
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0129 0.331 0.4879
Echinococcus granulosus biogenic amine 5HT receptor 0.0129 0.331 0.331
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0593 0.0831
Brugia malayi follicle stimulating hormone receptor 0.0129 0.331 0.4879
Schistosoma mansoni neuropeptide receptor 0.0129 0.331 0.4879
Onchocerca volvulus 0.0129 0.331 0.4889
Schistosoma mansoni voltage-gated potassium channel 0.0175 0.4812 0.7117
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.331 0.331
Plasmodium falciparum carbonic anhydrase 0.0127 0.3227 0.5
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0047 0.0593 0.0831
Schistosoma mansoni hypothetical protein 0.0129 0.331 0.4879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.331 0.3286
Echinococcus multilocularis dro:myosuppressin receptor 0.0129 0.331 0.3286
Schistosoma mansoni amine GPCR 0.0129 0.331 0.4879
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0129 0.331 0.3286
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0129 0.331 0.3286
Echinococcus multilocularis neuropeptide Y receptor 0.0129 0.331 0.3286
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127 0.3227 0.4756
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0129 0.331 0.3286
Brugia malayi putative neuropeptide receptor 0.0129 0.331 0.4879
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0161 0.4329 0.4329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0139 0.3634 0.5362
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0129 0.331 0.3286
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.331 0.3286
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0935 0.1245
Onchocerca volvulus 0.0129 0.331 0.4889
Brugia malayi Tachykinin-like peptides receptor 99D 0.0129 0.331 0.4879
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0593 0.0593
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0129 0.331 0.4879
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0185 0.512 0.5
Onchocerca volvulus 0.0129 0.331 0.4889
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni biogenic amine (5HT) receptor 0.0129 0.331 0.4879
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0129 0.331 0.4879
Echinococcus granulosus neuropeptides capa receptor 0.0129 0.331 0.331
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0129 0.331 0.4879
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0129 0.331 0.3286
Onchocerca volvulus 0.0129 0.331 0.4889
Brugia malayi ORL1-like opioid receptor 0.0129 0.331 0.4879
Echinococcus multilocularis neuropeptides capa receptor 0.0129 0.331 0.3286
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0129 0.331 0.4879
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0234 0.0234
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0593 0.056
Brugia malayi AKH receptor 0.0129 0.331 0.4879
Brugia malayi Serotonin receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus multilocularis g-protein coupled receptor 0.0129 0.331 0.3286
Brugia malayi GnHR receptor homolog 0.0129 0.331 0.4879
Echinococcus multilocularis G-protein coupled receptor, putative 0.0129 0.331 0.3286
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0185 0.512 0.7566
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni opsin-like receptor 0.0129 0.331 0.4879
Onchocerca volvulus 0.0129 0.331 0.4889
Schistosoma mansoni histamine h1 receptor 0.0129 0.331 0.4879
Echinococcus granulosus neuropeptide receptor 0.0129 0.331 0.331
Echinococcus multilocularis serotonin receptor 0.0129 0.331 0.3286
Schistosoma mansoni hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0234 0.6747 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0129 0.331 0.331
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0129 0.331 0.3286
Leishmania major carbonic anhydrase-like protein 0.0234 0.6747 1
Echinococcus multilocularis allatostatin A receptor 0.0129 0.331 0.3286
Echinococcus granulosus g protein coupled receptor 0.0129 0.331 0.331
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0234 0.6747 1
Onchocerca volvulus 0.0129 0.331 0.4889
Echinococcus multilocularis carbonic anhydrase II 0.0234 0.6747 0.6735
Echinococcus multilocularis fmrfamide receptor 0.0129 0.331 0.3286
Echinococcus granulosus neuropeptide receptor A26 0.0129 0.331 0.331
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus granulosus G protein coupled receptor 139 0.0129 0.331 0.331
Schistosoma mansoni opsin-like receptor 0.0129 0.331 0.4879
Echinococcus multilocularis neuropeptide Y receptor 0.0129 0.331 0.3286
Loa Loa (eye worm) melatonin receptor type 1A 0.0129 0.331 0.4879
Brugia malayi Melatonin receptor type 1A 0.0129 0.331 0.4879
Echinococcus granulosus orexin receptor type 2 0.0129 0.331 0.331
Onchocerca volvulus 0.0129 0.331 0.4889
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.331 0.4879
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0129 0.331 0.3286
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0161 0.4329 0.6397
Onchocerca volvulus 0.0129 0.331 0.4889
Echinococcus multilocularis neuropeptide receptor A26 0.0129 0.331 0.3286
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0129 0.331 0.3286
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0185 0.512 0.7577
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0234 0.6747 1
Echinococcus granulosus carbonic anhydrase 0.0127 0.3227 0.3227
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni hypothetical protein 0.0127 0.3227 0.4756
Loa Loa (eye worm) TYRA-2 protein 0.0129 0.331 0.4879
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0185 0.512 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.3902 0.5761
Loa Loa (eye worm) hypothetical protein 0.0127 0.3227 0.4756
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.011 0.0112
Onchocerca volvulus 0.0129 0.331 0.4889
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.011 0.0112
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0234 0.6747 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0234 0.6747 1
Brugia malayi neuropeptide F receptor 0.0129 0.331 0.4879
Echinococcus granulosus g-protein coupled receptor 0.0129 0.331 0.331
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0129 0.331 0.331
Loa Loa (eye worm) hypothetical protein 0.0121 0.3033 0.4466
Brugia malayi Dopamine receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus multilocularis G protein coupled receptor 139 0.0129 0.331 0.3286
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0129 0.331 0.4889
Brugia malayi RE15519p 0.0129 0.331 0.4879
Echinococcus multilocularis carbonic anhydrase 0.0127 0.3227 0.3203
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0129 0.331 0.331
Echinococcus multilocularis g protein coupled receptor 0.0129 0.331 0.3286
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2932 0.4316
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.011 0.0075
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Brugia malayi G protein-coupled receptor 0.0129 0.331 0.4879
Trichomonas vaginalis set domain proteins, putative 0.0234 0.6732 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0127 0.3227 0.4756
Schistosoma mansoni alpha-1 adrenergic receptor 0.0129 0.331 0.4879
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.011 0.0075
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0682 0.0964
Echinococcus multilocularis neuropeptide s receptor 0.0129 0.331 0.3286
Schistosoma mansoni hypothetical protein 0.0034 0.0172 0.0204
Echinococcus multilocularis carbonic anhydrase 0.0127 0.3227 0.3203
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0129 0.331 0.4879
Echinococcus granulosus neuropeptide receptor 0.0129 0.331 0.331
Brugia malayi hypothetical protein 0.0036 0.0234 0.0295
Echinococcus multilocularis neuropeptide receptor 0.0129 0.331 0.3286
Schistosoma mansoni neuropeptide F-like receptor 0.0129 0.331 0.4879
Echinococcus granulosus carbonic anhydrase 0.0127 0.3227 0.3227
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) G-protein coupled receptor 0.0129 0.331 0.4879
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0161 0.4329 0.4308
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0234 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.331 0.3286
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.331 0.3286
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.067 0.0945
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.015 0.3983 0.5848
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0129 0.331 0.4879
Brugia malayi MH2 domain containing protein 0.0118 0.2932 0.4316
Onchocerca volvulus 0.0129 0.331 0.4889
Echinococcus granulosus neuropeptide FF receptor 2 0.0129 0.331 0.331
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.011 0.0075
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0129 0.331 0.4879
Echinococcus multilocularis tumor protein p63 0.0334 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0234 0.6747 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni hypothetical protein 0.0167 0.4551 0.6729
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0935 0.1245
Schistosoma mansoni amine GPCR 0.0129 0.331 0.4879
Schistosoma mansoni biogenic amine receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus multilocularis fmrfamide receptor 0.0129 0.331 0.3286
Echinococcus granulosus g protein coupled receptor 0.0129 0.331 0.331
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.015 0.3983 0.5848
Schistosoma mansoni voltage-gated potassium channel 0.0175 0.4812 0.7117
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0234 0.6747 1
Echinococcus granulosus hypothetical protein 0.0129 0.331 0.331
Echinococcus granulosus muscleblind protein 0.0148 0.3902 0.3902
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0129 0.331 0.4879
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0129 0.331 0.4879
Echinococcus granulosus g protein coupled receptor 0.0129 0.331 0.331
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0036 0.0036
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Echinococcus granulosus somatostatin receptor 0.0129 0.331 0.331
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.011 0.011
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0129 0.331 0.331
Echinococcus multilocularis muscleblind protein 0.0148 0.3902 0.388
Onchocerca volvulus 0.0129 0.331 0.4889
Echinococcus granulosus 7tm_1 domain containing protein 0.0129 0.331 0.331
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0047 0.0593 0.0831
Echinococcus granulosus allatostatin A receptor 0.0129 0.331 0.331
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0593 0.056
Loa Loa (eye worm) hypothetical protein 0.0127 0.3227 0.4756
Schistosoma mansoni growth hormone secretagogue receptor 0.0129 0.331 0.4879
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0682 0.0964
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0185 0.512 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0129 0.331 0.331
Schistosoma mansoni carbonic anhydrase-related 0.0127 0.3227 0.4756
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.331 0.4879
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.331 0.331
Loa Loa (eye worm) hypothetical protein 0.0127 0.3227 0.4756
Schistosoma mansoni neuropeptide receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2932 0.4316
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.331 0.4879
Brugia malayi neuropeptide F receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0682 0.0964
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0129 0.331 0.3286
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.0204
Brugia malayi Serotonin receptor 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.011 0.0112
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0593 0.0831
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0129 0.331 0.4879
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.331 0.331
Brugia malayi hypothetical protein 0.0129 0.331 0.4879
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0129 0.331 0.4879
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.011 0.0112
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Echinococcus granulosus biogenic amine 5HT receptor 0.0129 0.331 0.331
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127 0.3227 0.4756
Brugia malayi G-protein coupled receptor 0.0129 0.331 0.4879
Echinococcus multilocularis serotonin receptor 0.0129 0.331 0.3286
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0185 0.512 0.7566
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0129 0.331 0.3286
Schistosoma mansoni carbonic anhydrase-related 0.0127 0.3227 0.4756
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0128 0.3255 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0129 0.331 0.331
Schistosoma mansoni neuropeptide receptor 0.0129 0.331 0.4879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.331 0.4879
Loa Loa (eye worm) hypothetical protein 0.0129 0.331 0.4879
Brugia malayi Dopamine receptor protein 1 0.0129 0.331 0.4879

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 9.92 uM In vitro cytotoxicity activity of compound against leukemia L1210 cell line ChEMBL. 15125953
T/C (functional) = 168 % In vivo antitumor activity of compound against leukemia L1210 cell line at 40 mg/kg ChEMBL. 15125953

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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