Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0357 | 0.4211 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.4211 | 0.4211 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0056 | 0 | 0.5 |
Onchocerca volvulus | 0.077 | 1 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0056 | 0 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0214 | 0.2216 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0301 | 0.3425 | 0.8134 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.4211 | 0.4211 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.1055 | 0.1055 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0357 | 0.4211 | 0.4211 |
Brugia malayi | Muscleblind-like protein | 0.0164 | 0.1518 | 0.1518 |
Leishmania major | endonuclease G, putative | 0.0214 | 0.2216 | 1 |
Onchocerca volvulus | 0.0357 | 0.4211 | 0.4211 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0164 | 0.1518 | 0.3604 |
Onchocerca volvulus | 0.0357 | 0.4211 | 0.4211 | |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0214 | 0.2216 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0164 | 0.1518 | 0.3604 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0357 | 0.4211 | 0.4211 |
Echinococcus granulosus | ectonucleotide | 0.0301 | 0.3425 | 0.8134 |
Echinococcus granulosus | muscleblind protein | 0.0164 | 0.1518 | 0.3604 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0357 | 0.4211 | 0.4211 |
Trypanosoma brucei | endonuclease G, putative | 0.0214 | 0.2216 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.077 | 1 | 1 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0214 | 0.2216 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0214 | 0.2216 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0056 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0214 | 0.2216 | 1 |
Schistosoma mansoni | hypothetical protein | 0.077 | 1 | 1 |
Schistosoma mansoni | endonuclease related | 0.0214 | 0.2216 | 0.2216 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1518 | 0.1518 |
Echinococcus multilocularis | Endonuclease G | 0.0214 | 0.2216 | 0.5262 |
Echinococcus granulosus | Endonuclease G | 0.0214 | 0.2216 | 0.5262 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.3425 | 0.3425 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.4211 | 0.4211 |
Trypanosoma brucei | endonuclease G, putative | 0.0214 | 0.2216 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.1055 | 0.1055 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0301 | 0.3425 | 0.8134 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0301 | 0.3425 | 0.8134 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0357 | 0.4211 | 0.4211 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0214 | 0.2216 | 0.2216 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.1055 | 0.1055 |
Mycobacterium leprae | hypothetical protein | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1518 | 0.1518 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0214 | 0.2216 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0357 | 0.4211 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0214 | 0.2216 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.