Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Mu opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Mu opioid receptor | 398 aa | 334 aa | 24.9 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Mu opioid receptor | 398 aa | 371 aa | 27.0 % |
Onchocerca volvulus | Mu opioid receptor | 398 aa | 376 aa | 26.3 % | |
Onchocerca volvulus | Mu opioid receptor | 398 aa | 356 aa | 23.9 % | |
Echinococcus multilocularis | allatostatin A receptor | Mu opioid receptor | 398 aa | 341 aa | 29.3 % |
Onchocerca volvulus | Mu opioid receptor | 398 aa | 333 aa | 26.4 % | |
Schistosoma japonicum | Rhodopsin, putative | Mu opioid receptor | 398 aa | 328 aa | 23.2 % |
Onchocerca volvulus | Programmed cell death protein 5 homolog | Mu opioid receptor | 398 aa | 323 aa | 24.1 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Mu opioid receptor | 398 aa | 397 aa | 22.7 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Mu opioid receptor | 398 aa | 334 aa | 23.1 % |
Schistosoma mansoni | neuropeptide F-like receptor | Mu opioid receptor | 398 aa | 335 aa | 20.6 % |
Echinococcus granulosus | allatostatin A receptor | Mu opioid receptor | 398 aa | 346 aa | 29.5 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Mu opioid receptor | 398 aa | 370 aa | 27.3 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration (functional) | = 6.16 min | Duration of analgesic effect using mouse hot plate assay | ChEMBL. | 2170652 |
Duration (functional) | = 6.16 min | Duration of analgesic effect using mouse hot plate assay | ChEMBL. | 2170652 |
Duration (functional) | = 7.2 min | Duration of analgesic effect using mouse hot plate assay | ChEMBL. | 2170652 |
Duration (functional) | = 7.2 min | Duration of analgesic effect using mouse hot plate assay | ChEMBL. | 2170652 |
Duration (functional) | = 24 min | Duration of action of the compound in mouse hot plate, less than 9 min at 8 times ED50 was evaluated | ChEMBL. | 2170652 |
Duration (functional) | = 24 min | Duration of action of the compound in mouse hot plate, less than 9 min at 8 times ED50 was evaluated | ChEMBL. | 2170652 |
ED50 (functional) | = 0.118 mg kg-1 | Tested for analgesic activity using hot plate technique at 55 degree centigrade in the mouse | ChEMBL. | 2170652 |
ED50 (functional) | = 0.118 mg kg-1 | Tested for analgesic activity using hot plate technique at 55 degree centigrade in the mouse | ChEMBL. | 2170652 |
ED50 (functional) | = 0.217 mg kg-1 | Tested for analgesic activity using hot plate technique at 55 degree centigrade in the mouse | ChEMBL. | 2170652 |
ED50 (functional) | = 0.217 mg kg-1 | Tested for analgesic activity using hot plate technique at 55 degree centigrade in the mouse | ChEMBL. | 2170652 |
Ki (binding) | = 0.78 nM | Ability to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from the rat brain membranes. | ChEMBL. | 2170652 |
Ki (binding) | = 0.78 nM | Ability to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from the rat brain membranes. | ChEMBL. | 2170652 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.