Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0273 | 0.0945 | 0.5 | |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.052 | 0.2002 | 0.2002 |
Schistosoma mansoni | tyrosine kinase | 0.0076 | 0.0102 | 0.0135 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0076 | 0.0102 | 0.0053 |
Schistosoma mansoni | choline o-acyltransferase | 0.0273 | 0.0945 | 0.1247 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0076 | 0.0102 | 0.0053 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1151 | 0.4695 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.1857 | 0.7715 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1151 | 0.4695 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1824 | 0.7574 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.1857 | 0.7715 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1151 | 0.4695 | 0.6054 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0273 | 0.0945 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.2392 | 1 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0067 | 0.0062 | 0.0082 |
Onchocerca volvulus | 0.0273 | 0.0945 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0076 | 0.0102 | 0.0053 |
Schistosoma mansoni | nck2/grb4 | 0.0067 | 0.0062 | 0.0082 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.052 | 0.2002 | 0.2002 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0076 | 0.0102 | 0.0053 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1151 | 0.4695 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0076 | 0.0102 | 0.0053 |
Brugia malayi | Choline O-acetyltransferase | 0.0273 | 0.0945 | 0.0945 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0076 | 0.0102 | 0.0053 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0273 | 0.0945 | 0.0945 |
Schistosoma mansoni | tyrosine kinase | 0.0076 | 0.0102 | 0.0135 |
Onchocerca volvulus | 0.0273 | 0.0945 | 0.5 | |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0076 | 0.0102 | 0.0135 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0076 | 0.0102 | 0.0053 |
Brugia malayi | Variant SH3 domain containing protein | 0.0067 | 0.0062 | 0.0062 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0273 | 0.0945 | 0.1153 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0076 | 0.0102 | 0.0053 |
Schistosoma mansoni | adapter molecule crk | 0.0067 | 0.0062 | 0.0082 |
Schistosoma mansoni | tyrosine kinase | 0.0076 | 0.0102 | 0.0135 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0076 | 0.0102 | 0.0053 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.052 | 0.2002 | 0.2535 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0076 | 0.0102 | 0.0053 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0076 | 0.0102 | 0.0053 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0067 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0067 | 0.0062 | 0.0062 |
Onchocerca volvulus | 0.0273 | 0.0945 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.052 | 0.2002 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0076 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0067 | 0.0062 | 0.0062 |
Brugia malayi | Choline O-acetyltransferase | 0.0273 | 0.0945 | 0.0945 |
Schistosoma mansoni | choline o-acyltransferase | 0.0273 | 0.0945 | 0.1247 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0076 | 0.0102 | 0.0053 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0067 | 0.0062 | 0.0082 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0076 | 0.0102 | 0.0053 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0076 | 0.0102 | 0.0053 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0076 | 0.0102 | 0.0053 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0067 | 0.0062 | 0.0082 |
Schistosoma mansoni | tyrosine kinase | 0.0076 | 0.0102 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0062 | 0.0062 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1151 | 0.4695 | 0.6054 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0076 | 0.0102 | 0.0102 |
Brugia malayi | SRC-1 | 0.0076 | 0.0102 | 0.0102 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.052 | 0.2002 | 0.2819 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0076 | 0.0102 | 0.0053 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0076 | 0.0102 | 0.0053 |
Brugia malayi | Variant SH3 domain containing protein | 0.0067 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0273 | 0.0945 | 0.0945 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.052 | 0.2002 | 0.2819 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0076 | 0.0102 | 0.0053 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0076 | 0.0102 | 0.0053 |
Echinococcus granulosus | choline O acetyltransferase | 0.0273 | 0.0945 | 0.1153 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0076 | 0.0102 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0945 | 0.0945 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.052 | 0.2002 | 0.2535 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.