Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hexokinase family protein | 0.008 | 0.1098 | 0.1098 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0058 | 0.0000014891 | 0.0000014891 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0058 | 0.0000014891 | 0.0000014891 |
Loa Loa (eye worm) | hexokinase | 0.008 | 0.1098 | 0.1098 |
Schistosoma mansoni | transient receptor potential channel | 0.0058 | 0.0000014891 | 0.0000014891 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0000014891 | 0.0000014891 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1208 | 0.1208 |
Brugia malayi | Hexokinase family protein | 0.0163 | 0.5197 | 0.5197 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1208 | 0.1208 |
Loa Loa (eye worm) | hexokinase | 0.0163 | 0.5197 | 0.5197 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0058 | 0.0000014891 | 0.0000014891 |
Brugia malayi | olfactory channel protein osm-9 | 0.0058 | 0.0000014891 | 0.0000014891 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5902 | 0.5902 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0058 | 0.0000014891 | 0.0000014891 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0000014891 | 0.0000014891 |
Onchocerca volvulus | Hexokinase homolog | 0.0163 | 0.5197 | 0.5197 |
Brugia malayi | hexokinase type II | 0.0083 | 0.1208 | 0.1208 |
Schistosoma mansoni | transient receptor potential channel | 0.0058 | 0.0000014891 | 0.0000014891 |
Onchocerca volvulus | 0.0163 | 0.5197 | 0.5197 | |
Echinococcus granulosus | transient receptor potential cation channel | 0.0058 | 0.0000014891 | 0.0000014891 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0000014891 | 0.0000014891 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0058 | 0.0000014891 | 0.0000014891 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 0.22 uM | Inhibition of recombinant human CYP3A4 in supersomes using midazolam as substrate after 5 mins by LC-MS/MS analysis | ChEMBL. | 22264486 |
Inhibition (ADMET) | = 30 % | Inhibition of recombinant human CYP3A5 in supersomes using midazolam as substrate at 60 uM after 5 mins by LC-MS/MS analysis | ChEMBL. | 22264486 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.