Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Loa Loa (eye worm) | brix domain-containing protein | 0.0133 | 0.3202 | 0.7808 |
Trypanosoma brucei | brix domain containing protein, putative | 0.0133 | 0.3202 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0133 | 0.3202 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.4101 | 0.3797 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Giardia lamblia | Peter pan protein | 0.0133 | 0.3202 | 0.5 |
Trichomonas vaginalis | ssf, putative | 0.0133 | 0.3202 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 1 | 1 |
Echinococcus granulosus | zinc finger protein 598 | 0.0132 | 0.3166 | 0.3166 |
Entamoeba histolytica | brix domain containing protein | 0.0133 | 0.3202 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.0133 | 0.3202 | 0.2852 |
Brugia malayi | Brix domain containing protein | 0.0133 | 0.3202 | 0.7511 |
Schistosoma mansoni | P2X receptor subunit | 0.0143 | 0.3635 | 0.3306 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.1045 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.049 | 0.1195 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0288 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0153 | 0.4101 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0288 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0143 | 0.3635 | 0.3306 |
Onchocerca volvulus | 0.0153 | 0.4101 | 1 | |
Echinococcus multilocularis | peter pan | 0.0133 | 0.3202 | 0.3202 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Schistosoma mansoni | peter pan-related | 0.0133 | 0.3202 | 0.2852 |
Leishmania major | peter pan protein, putative | 0.0133 | 0.3202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.049 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.049 | 0.1195 |
Plasmodium falciparum | BRIX domain, putative | 0.0133 | 0.3202 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Trypanosoma cruzi | peter pan protein, putative | 0.0133 | 0.3202 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0153 | 0.4101 | 1 |
Echinococcus multilocularis | zinc finger protein 598 | 0.0132 | 0.3166 | 0.3166 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Schistosoma mansoni | P2X receptor subunit | 0.0288 | 1 | 1 |
Toxoplasma gondii | brix domain-containing protein | 0.0133 | 0.3202 | 0.5 |
Echinococcus granulosus | peter pan | 0.0133 | 0.3202 | 0.3202 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Onchocerca volvulus | Peter pan protein homolog | 0.0133 | 0.3202 | 0.7511 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0288 | 1 | 1 |
Trypanosoma cruzi | peter pan protein, putative | 0.0133 | 0.3202 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.049 | 0.049 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibitory activity (binding) | = 4536 nM | Inhibitory activity against serine protease chymase was determined | ChEMBL. | 12467610 |
Inhibitory activity (binding) | = 4536 nM | Inhibitory activity against serine protease chymase was determined | ChEMBL. | 12467610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.