Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0139 | 0.0197 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.0197 | 0.0196 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0139 | 0.0197 | 0.0196 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0139 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0197 | 0.0197 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0139 | 0.0197 | 0.0196 |
Treponema pallidum | hypothetical protein | 0.0139 | 0.0197 | 0.5 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0139 | 0.0197 | 0.5 |
Schistosoma mansoni | na/ca exchanger | 0.0139 | 0.0197 | 0.0196 |
Brugia malayi | Sodium/calcium exchanger protein | 0.2204 | 0.3966 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0139 | 0.0197 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0197 | 0.0197 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0139 | 0.0197 | 0.0495 |
Echinococcus multilocularis | sodium calcium exchanger | 0.5509 | 1 | 1 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0139 | 0.0197 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0806 | 0.1415 | 0.1414 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0806 | 0.1415 | 0.1414 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0139 | 0.0197 | 0.5 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0139 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.2204 | 0.3966 | 0.3966 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0139 | 0.0197 | 0.0196 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0972 | 0.1717 | 1 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0139 | 0.0197 | 0.0196 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0139 | 0.0197 | 1 |
Loa Loa (eye worm) | solute carrier family 8 | 0.5509 | 1 | 1 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0139 | 0.0197 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0001 | 0.0001 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0972 | 0.1717 | 1 |
Schistosoma mansoni | sodium/calcium exchanger | 0.5509 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0197 | 0.0197 |
Plasmodium falciparum | cation/H+ antiporter | 0.0139 | 0.0197 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0001 | 0.0001 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0139 | 0.0197 | 0.0495 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0806 | 0.1415 | 0.1414 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.74 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.694 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.655 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.651 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.487 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.462 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.445 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.362 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.351 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.