Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 259 aa | 254 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0126 | 0.0134 | 0.0222 |
Echinococcus multilocularis | serotonin receptor | 0.0126 | 0.0134 | 0.176 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0188 | 0.0448 | 0.5883 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.11 | 0.5038 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0287 | 0.0946 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0164 | 0.0328 | 0.431 |
Loa Loa (eye worm) | hypothetical protein | 0.11 | 0.5038 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0126 | 0.0134 | 0.176 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.025 | 0.0761 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0214 | 0.0578 | 0.7155 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.0571 | 0.1133 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0123 | 0.012 | 0.1573 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0164 | 0.0328 | 0.3248 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.2086 | 1 | 0.5 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta | 0.2086 | 1 | 0.5 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) | 0.2086 | 1 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0123 | 0.012 | 0.1573 |
Echinococcus granulosus | nmda type glutamate receptor | 0.025 | 0.0761 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0189 | 0.0451 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0123 | 0.012 | 0.1573 |
Leishmania major | C-8 sterol isomerase-like protein | 0.11 | 0.5038 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0126 | 0.0134 | 0.1415 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.0571 | 0.1133 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0214 | 0.0578 | 0.6114 |
Onchocerca volvulus | 0.0242 | 0.0719 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0451 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0134 | 0.0266 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.11 | 0.5038 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0123 | 0.012 | 0.1573 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.0719 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0134 | 0.0266 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0123 | 0.012 | 0.1573 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta | 0.2086 | 1 | 1 |
Plasmodium falciparum | DNA-directed RNA polymerase subunit beta, putative | 0.2086 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.2332 | 0.4628 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0214 | 0.0578 | 0.7602 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.11 | 0.5038 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0189 | 0.0451 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0188 | 0.0448 | 0.5115 |
Mycobacterium tuberculosis | DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) | 0.2086 | 1 | 0.5 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0189 | 0.0451 | 0.0896 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | nM | Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 2 from human prostate homogenates; No inhibition | ChEMBL. | 9873639 |
IC50 (binding) | 0 nM | Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 2 from human prostate homogenates; No inhibition | ChEMBL. | 9873639 |
IC50 (binding) | = 5130 nM | Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 from recombinant CHO cells | ChEMBL. | 9873639 |
IC50 (binding) | = 5130 nM | Inhibition of human Steroid 5-alpha-reductase type I | ChEMBL. | 10714498 |
IC50 (binding) | = 5130 nM | Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells | ChEMBL. | 11020287 |
IC50 (binding) | = 5130 nM | Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 from recombinant CHO cells | ChEMBL. | 9873639 |
IC50 (binding) | = 5130 nM | Inhibition of human Steroid 5-alpha-reductase type I | ChEMBL. | 10714498 |
IC50 (binding) | = 5130 nM | Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells | ChEMBL. | 11020287 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.