Detailed information for compound 1627368

Basic information

Technical information
  • TDR Targets ID: 1627368
  • Name: AIDS106645
  • MW: 385.372 | Formula: C22H15N3O4
  • H donors: 3 H acceptors: 2 LogP: 3.59 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c1c([nH]2)c2[nH]c3c(c2c2c1c(=O)[nH]c2=O)cc(cc3)OC
  • InChi: 1S/C22H15N3O4/c1-28-9-3-5-13-11(7-9)15-17-18(22(27)25-21(17)26)16-12-8-10(29-2)4-6-14(12)24-20(16)19(15)23-13/h3-8,23-24H,1-2H3,(H,25,26,27)
  • InChiKey: LGTURXDQKJRHSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 12,13-Dihydro-3,9-dimethoxy-5H-indolo[2,3-a]pyrrolo[3,4-a]carbazole-5,7-(6H)-dione
  • AIDS-106645

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens platelet-derived growth factor receptor, beta polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0016 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.2497 0.2428
Echinococcus multilocularis plexin a4 0.0102 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.4108 0.4054
Brugia malayi Sema domain containing protein 0.0036 0.2497 0.2348
Loa Loa (eye worm) TK/KIN16 protein kinase 0.002 0.0686 0.0601
Brugia malayi Plexin repeat family protein 0.0086 0.8205 0.8169
Echinococcus multilocularis transcription factor collier 0.0016 0.0194 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.2497 0.2428
Schistosoma mansoni hypothetical protein 0.005 0.4108 0.5006
Schistosoma mansoni hypothetical protein 0.0036 0.2497 0.3043
Schistosoma mansoni semaphorin 5-related 0.0036 0.2497 0.3043
Echinococcus multilocularis roundabout 2 0.0018 0.0416 0.0416
Echinococcus granulosus semaphorin 1A 0.0036 0.2497 0.2497
Loa Loa (eye worm) hypothetical protein 0.0036 0.2497 0.2428
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0016 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.2497 0.2428
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0105
Schistosoma mansoni hypothetical protein 0.0016 0.0194 0.0237
Loa Loa (eye worm) plexin A 0.0102 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0105
Loa Loa (eye worm) hypothetical protein 0.0036 0.2497 0.2428
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0194 0.5
Brugia malayi hypothetical protein 0.0036 0.2497 0.2348
Loa Loa (eye worm) hypothetical protein 0.0036 0.2497 0.2428
Brugia malayi hypothetical protein 0.0036 0.2497 0.2348
Entamoeba histolytica tyrosin kinase, putative 0.0021 0.079 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0194 0.5
Echinococcus multilocularis hypothetical protein 0.0036 0.2497 0.2497
Schistosoma mansoni plexin 0.005 0.4108 0.5006
Echinococcus multilocularis semaphorin 5B 0.0036 0.2497 0.2497
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0016 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.8205 0.8189
Echinococcus granulosus semaphorin 5B 0.0036 0.2497 0.2497
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0686 0.0501
Loa Loa (eye worm) sema domain-containing protein 0.0036 0.2497 0.2428
Entamoeba histolytica protein kinase domain containing protein 0.0021 0.079 1
Echinococcus multilocularis exocyst complex component 2 0.0016 0.0194 0.0194
Schistosoma mansoni plexin 0.0086 0.8205 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0416 0.0329
Loa Loa (eye worm) sema domain-containing protein 0.0036 0.2497 0.2428
Echinococcus granulosus transcription factor collier 0.0016 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0018 0.0416 0.0329
Schistosoma mansoni hypothetical protein 0.0016 0.0194 0.0237
Schistosoma mansoni fibrocystin l 0.0016 0.0194 0.0237
Onchocerca volvulus 0.0086 0.8205 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0105
Echinococcus granulosus roundabout 2 0.0018 0.0416 0.0416
Schistosoma mansoni hypothetical protein 0.0036 0.2497 0.3043
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0016 0.0194 0.5
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0016 0.0194 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0194 0.5
Schistosoma mansoni cell adhesion molecule 0.0015 0.009 0.011
Echinococcus granulosus exocyst complex component 2 0.0016 0.0194 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0194 0.5
Brugia malayi Sema domain containing protein 0.0036 0.2497 0.2348
Echinococcus granulosus plexin a4 0.0102 1 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = uM GSK_PKIS: Inhibition of Firefly Luciferase (Data from PubChem: AID 652016) [NIH NCATS] ChEMBL. No reference
AC50 (binding) = 25.9023 uM GSK_PKIS: Inhibition of Sea Pansy Luciferase (Data from PubChem: AID 652015) [NIH NCATS] ChEMBL. No reference
IC50 (binding) = 1.8 uM Inhibition of recombinant cytoplasmic domain of PDGFRbeta autophosphorylation expressed in baculovirus infected Sf21 insect cells using [gamma-33P]ATP by SDS-PAGE based scintillation counting ChEMBL. 10048786
IC50 (binding) = 2 uM Inhibition of recombinant cytoplasmic domain of PDGFRbeta expressed in baculovirus infected Sf21 insect cells assessed as tyrosine phosphorylation treated 30 hrs after infection measured after 48 hrs of post infection by Western blotting ChEMBL. 10048786
Inhibition (binding) Inhibition of recombinant cytoplasmic domain of PDGFRbeta expressed in baculovirus infected Sf21 insect cells using poly(Glu4,Tyr1) and [gamma-33P]ATP at 100 uM by SDS-PAGE based scintillation counting ChEMBL. 10048786
Inhibition (binding) Inhibition of recombinant cytoplasmic domain of PDGFRbeta expressed in baculovirus infected Sf21 insect cells assessed as tyrosine phosphorylation treated 30 hrs after infection measured after 48 hrs of post infection by Western blotting ChEMBL. 10048786
Inhibition (binding) Inhibition of recombinant cytoplasmic domain of PDGFRbeta autophosphorylation expressed in baculovirus infected Sf21 insect cells using [gamma-33P]ATP by SDS-PAGE based scintillation counting ChEMBL. 10048786
Inhibition (binding) Inhibition of recombinant cytoplasmic domain of PDGFRbeta expressed in baculovirus infected Sf21 insect cells using 10 fold less poly(Glu4,Tyr1) and [gamma-33P]ATP at 100 uM by SDS-PAGE based scintillation counting ChEMBL. 10048786
Inhibition (binding) = -7.81 % GSK_PKIS: SYK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -5.78 % GSK_PKIS: CAMK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -5 % GSK_PKIS: IKK-beta % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = -4.62 % GSK_PKIS: EPHB3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -3.69 % GSK_PKIS: CAMK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -3.65 % GSK_PKIS: SPHK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -2.69 % GSK_PKIS: BMX mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -2.46 % GSK_PKIS: SPHK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -2.11 % GSK_PKIS: TYK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.72 % GSK_PKIS: CRAF mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.68 % GSK_PKIS: SPHK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.59 % GSK_PKIS: CRAF mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.55 % GSK_PKIS: PI4K-beta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.47 % GSK_PKIS: PASK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.31 % GSK_PKIS: JAK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.14 % GSK_PKIS: JAK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.07 % GSK_PKIS: IRAK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.01 % GSK_PKIS: SRC mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1 % GSK_PKIS: SRPK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1 % GSK_PKIS: IKK-beta % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = -0.86 % GSK_PKIS: MRCKB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.61 % GSK_PKIS: JAK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.6 % GSK_PKIS: TYK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.49 % GSK_PKIS: PASK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.34 % GSK_PKIS: PAK6 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.32 % GSK_PKIS: SPHK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.26 % GSK_PKIS: PTK5 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.12 % GSK_PKIS: PI4K-beta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.01 % GSK_PKIS: EPHB4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.07 % GSK_PKIS: BTK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.15 % GSK_PKIS: PKC-iota mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.17 % GSK_PKIS: CDK1/cyclinB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.56 % GSK_PKIS: AKT1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.68 % GSK_PKIS: PTK5 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.72 % GSK_PKIS: PKC-iota mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.76 % GSK_PKIS: NEK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.8 % GSK_PKIS: P38delta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.84 % GSK_PKIS: MRCKA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.84 % GSK_PKIS: EPHB3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.85 % GSK_PKIS: EPHA2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.96 % GSK_PKIS: JAK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.03 % GSK_PKIS: P38gamma mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.11 % GSK_PKIS: CDK5/p35 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.15 % GSK_PKIS: ROCK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.23 % GSK_PKIS: MSSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.24 % GSK_PKIS: DCAMKL2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.36 % GSK_PKIS: TIE2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.39 % GSK_PKIS: AKT3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.43 % GSK_PKIS: PAK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.45 % GSK_PKIS: AKT2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.55 % GSK_PKIS: PKC-beta1 (splice variant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.57 % GSK_PKIS: PAR-1Balpha mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.75 % GSK_PKIS: GSK3A mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.76 % GSK_PKIS: ERBB2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.76 % GSK_PKIS: FGFR1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.85 % GSK_PKIS: CDK2/cyclinA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.85 % GSK_PKIS: ITK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.99 % GSK_PKIS: NEK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2 % GSK_PKIS: DAPK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.06 % GSK_PKIS: MAP4K2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.1 % GSK_PKIS: NEK9 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.15 % GSK_PKIS: CK1a mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.17 % GSK_PKIS: CLK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.26 % GSK_PKIS: FGFR4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.31 % GSK_PKIS: CDK3/cyclinE mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.32 % GSK_PKIS: CK1-g2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.46 % GSK_PKIS: FLT1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.48 % GSK_PKIS: PRAK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.51 % GSK_PKIS: TXK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.52 % GSK_PKIS: EPHA2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.54 % GSK_PKIS: AKT2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.55 % GSK_PKIS: DYRK1B mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.56 % GSK_PKIS: CDK4/cyclinD mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.57 % GSK_PKIS: CDK5/p35 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.61 % GSK_PKIS: MAPKAPK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.68 % GSK_PKIS: ZAP70 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.7 % GSK_PKIS: AKT3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.74 % GSK_PKIS: P38delta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.8 % GSK_PKIS: DDR2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.81 % GSK_PKIS: DCAMKL2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.87 % GSK_PKIS: EGFR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.91 % GSK_PKIS: CDK6/cyclinD3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.96 % GSK_PKIS: NEK9 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.96 % GSK_PKIS: MRCKB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3 % GSK_PKIS: CDK2/cyclinA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.01 % GSK_PKIS: PLK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.1 % GSK_PKIS: ARG mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.1 % GSK_PKIS: CK1-g2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.15 % GSK_PKIS: P38beta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.2 % GSK_PKIS: FGFR1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.22 % GSK_PKIS: CDK1/cyclinB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.27 % GSK_PKIS: IRR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.34 % GSK_PKIS: SRMS mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.41 % GSK_PKIS: TSSK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.43 % GSK_PKIS: FES mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.47 % GSK_PKIS: TRKA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.5 % GSK_PKIS: MAPK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.51 % GSK_PKIS: PAK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.53 % GSK_PKIS: KIT (V560G mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.54 % GSK_PKIS: IKKB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.6 % GSK_PKIS: CDK6/cyclinD3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.62 % GSK_PKIS: FYN mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.64 % GSK_PKIS: CDK2/cyclinE mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.67 % GSK_PKIS: EGFR (T790M mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.68 % GSK_PKIS: PKC-beta2 (splice variant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.71 % GSK_PKIS: NEK7 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.82 % GSK_PKIS: PKC-eta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.92 % GSK_PKIS: MARK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.92 % GSK_PKIS: GSK3B mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.93 % GSK_PKIS: MARK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.95 % GSK_PKIS: FGFR4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.96 % GSK_PKIS: TSSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4 % GSK_PKIS: PAK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.03 % GSK_PKIS: PKA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.06 % GSK_PKIS: CK1-g3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.07 % GSK_PKIS: PKC-gamma mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.16 % GSK_PKIS: P38gamma mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.21 % GSK_PKIS: CK1-g1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.21 % GSK_PKIS: EPHB4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.22 % GSK_PKIS: IGF1R mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.27 % GSK_PKIS: PKC-alpha mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.27 % GSK_PKIS: MST4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.28 % GSK_PKIS: HIPK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.28 % GSK_PKIS: AKT1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.3 % GSK_PKIS: CSK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.36 % GSK_PKIS: NEK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.44 % GSK_PKIS: CLK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.46 % GSK_PKIS: PAK5 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.48 % GSK_PKIS: PI3K-delta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.49 % GSK_PKIS: PAK6 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.52 % GSK_PKIS: IRAK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.65 % GSK_PKIS: JNK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.65 % GSK_PKIS: P38alpha mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.69 % GSK_PKIS: PKC-theta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.71 % GSK_PKIS: IKKB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.72 % GSK_PKIS: LCK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.75 % GSK_PKIS: FGFR2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.82 % GSK_PKIS: CK1-g1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.83 % GSK_PKIS: TSSK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.86 % GSK_PKIS: MEK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.91 % GSK_PKIS: CDK2/cyclinE mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.93 % GSK_PKIS: MAPK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.97 % GSK_PKIS: MUSK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5 % GSK_PKIS: CK1-g3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5 % GSK_PKIS: TIE2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5 % GSK_PKIS: Mer Kinase % inhibition at 10 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 5.01 % GSK_PKIS: MAPKAPK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.01 % GSK_PKIS: BRAF (V599E mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.02 % GSK_PKIS: PRKD1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.05 % GSK_PKIS: BRAF mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.12 % GSK_PKIS: CLK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.14 % GSK_PKIS: NEK6 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.17 % GSK_PKIS: HIPK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.28 % GSK_PKIS: IKKA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.28 % GSK_PKIS: IGF1R mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.28 % GSK_PKIS: NEK7 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.29 % GSK_PKIS: MAPKAPK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.31 % GSK_PKIS: PRKD3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.36 % GSK_PKIS: NEK6 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.41 % GSK_PKIS: PAK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.43 % GSK_PKIS: PAK5 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.44 % GSK_PKIS: MAPK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.57 % GSK_PKIS: TNK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.61 % GSK_PKIS: PAK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.69 % GSK_PKIS: CK1a mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.74 % GSK_PKIS: NEK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.78 % GSK_PKIS: EPHA3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.83 % GSK_PKIS: ERBB2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.89 % GSK_PKIS: JAK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.02 % GSK_PKIS: CDK3/cyclinE mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.04 % GSK_PKIS: MAPKAPK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.11 % GSK_PKIS: ITK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.13 % GSK_PKIS: PRKG1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.14 % GSK_PKIS: BLK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.24 % GSK_PKIS: GSK3A mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.28 % GSK_PKIS: RON mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.32 % GSK_PKIS: ABL1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.32 % GSK_PKIS: EPHA3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.37 % GSK_PKIS: BRK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.39 % GSK_PKIS: MKNK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.4 % GSK_PKIS: CK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.5 % GSK_PKIS: SRPK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.62 % GSK_PKIS: ROCK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.69 % GSK_PKIS: BRAF (V599E mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.75 % GSK_PKIS: YES mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.77 % GSK_PKIS: PI3K-alpha mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.78 % GSK_PKIS: KIT (T6701 mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.81 % GSK_PKIS: DYRK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.84 % GSK_PKIS: IKKA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.89 % GSK_PKIS: TEC mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.91 % GSK_PKIS: INSR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.91 % GSK_PKIS: MAPK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.93 % GSK_PKIS: IRR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.96 % GSK_PKIS: CAMK1D mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.99 % GSK_PKIS: CAMK2A mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.02 % GSK_PKIS: ROCK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.06 % GSK_PKIS: MEK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.22 % GSK_PKIS: EGFR (L861Q mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.28 % GSK_PKIS: Aurora-A mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.55 % GSK_PKIS: CDK4/cyclinD mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.66 % GSK_PKIS: P38beta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.67 % GSK_PKIS: LYN B (splice variant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.7 % GSK_PKIS: FGFR3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.72 % GSK_PKIS: PAK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.79 % GSK_PKIS: TRKB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.83 % GSK_PKIS: BRAF mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.87 % GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.99 % GSK_PKIS: MARK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.15 % GSK_PKIS: PRKD2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.32 % GSK_PKIS: BTK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.34 % GSK_PKIS: MNK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.6 % GSK_PKIS: ZAP70 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.8 % GSK_PKIS: PRAK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.83 % GSK_PKIS: TRKC mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.91 % GSK_PKIS: PKC-beta1 (splice variant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.06 % GSK_PKIS: PHKG2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.07 % GSK_PKIS: PRKX mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.29 % GSK_PKIS: PLK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.34 % GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.7 % GSK_PKIS: EGFR (T790M-L858R mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.72 % GSK_PKIS: LOK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.75 % GSK_PKIS: CSK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.76 % GSK_PKIS: SGK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.05 % GSK_PKIS: PI3K-delta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.06 % GSK_PKIS: EPHA4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.07 % GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.12 % GSK_PKIS: DYRK1A mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.28 % GSK_PKIS: INSR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.4 % GSK_PKIS: FES mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.5 % GSK_PKIS: MET mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.5 % GSK_PKIS: SYK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.67 % GSK_PKIS: MER mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.69 % GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.73 % GSK_PKIS: EPHB2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.77 % GSK_PKIS: P38alpha mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.81 % GSK_PKIS: LYN A (splice variant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.82 % GSK_PKIS: FGR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.86 % GSK_PKIS: TBK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.96 % GSK_PKIS: AXL mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.48 % GSK_PKIS: MKNK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.58 % GSK_PKIS: TSSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.74 % GSK_PKIS: PKC-gamma mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.76 % GSK_PKIS: MRCKA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.77 % GSK_PKIS: MSK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.79 % GSK_PKIS: MUSK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.81 % GSK_PKIS: PAR-1Balpha mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12 % GSK_PKIS: IKK-alpha % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 12.08 % GSK_PKIS: ARG mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.1 % GSK_PKIS: MAP4K2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.39 % GSK_PKIS: Aurora-C mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.76 % GSK_PKIS: JAK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.87 % GSK_PKIS: PKC-beta2 (splice variant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.93 % GSK_PKIS: FMS mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13 % GSK_PKIS: IKK-alpha % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 13.01 % GSK_PKIS: MST1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.49 % GSK_PKIS: IKKE mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.81 % GSK_PKIS: ALK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.98 % GSK_PKIS: MST4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 14.23 % GSK_PKIS: MST2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 14.45 % GSK_PKIS: PRKD3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 14.52 % GSK_PKIS: ERBB4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 14.6 % GSK_PKIS: TXK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 14.61 % GSK_PKIS: PI3K-alpha mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 14.68 % GSK_PKIS: GSK3B mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15.19 % GSK_PKIS: FGFR3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15.4 % GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15.47 % GSK_PKIS: TTK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15.61 % GSK_PKIS: SRMS mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15.88 % GSK_PKIS: MARK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15.94 % GSK_PKIS: CK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15.99 % GSK_PKIS: TNK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 16.42 % GSK_PKIS: FGFR2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 16.56 % GSK_PKIS: ROCK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 16.57 % GSK_PKIS: TRKA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 16.63 % GSK_PKIS: BMX mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 16.64 % GSK_PKIS: SGK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 16.79 % GSK_PKIS: DDR2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 16.85 % GSK_PKIS: RON mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.09 % GSK_PKIS: TYRO3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.17 % GSK_PKIS: PKA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.45 % GSK_PKIS: CAMK2D mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.62 % GSK_PKIS: EPHB2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.85 % GSK_PKIS: EGFR (T790M mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.86 % GSK_PKIS: AMPKA2 (A2B1G1) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 18.12 % GSK_PKIS: MNK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 18.19 % GSK_PKIS: EGFR (L858R mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 18.33 % GSK_PKIS: MSSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 18.46 % GSK_PKIS: FLT4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 18.71 % GSK_PKIS: MSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 18.99 % GSK_PKIS: FYN mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 19.18 % GSK_PKIS: FLT1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 19.48 % GSK_PKIS: PKC-eta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 19.64 % GSK_PKIS: BRK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 19.75 % GSK_PKIS: MET mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 20 % GSK_PKIS: IKK-epsilon % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 20.15 % GSK_PKIS: HCK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 20.2 % GSK_PKIS: GRK6 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 20.34 % GSK_PKIS: CLK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 20.35 % GSK_PKIS: SRC mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 20.66 % GSK_PKIS: Aurora-B mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 20.73 % GSK_PKIS: HIPK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 20.81 % GSK_PKIS: LRRK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 20.85 % GSK_PKIS: PKC-theta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 21 % GSK_PKIS: IKK-epsilon % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 21.1 % GSK_PKIS: LCK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 21.16 % GSK_PKIS: EGFR (L861Q mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 21.38 % GSK_PKIS: PIM2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 21.71 % GSK_PKIS: JNK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 21.77 % GSK_PKIS: SGK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 22.29 % GSK_PKIS: MELK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 22.35 % GSK_PKIS: CHEK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 22.63 % GSK_PKIS: EPHA4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 22.72 % GSK_PKIS: GRK7 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 22.76 % GSK_PKIS: HIPK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 22.86 % GSK_PKIS: CAMK2A mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 23.3 % GSK_PKIS: EGFR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 24.34 % GSK_PKIS: LRRK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 24.81 % GSK_PKIS: DAPK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 26.12 % GSK_PKIS: DYRK1B mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 26.63 % GSK_PKIS: GRK7 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 26.95 % GSK_PKIS: SNF1LK (SIK) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 26.97 % GSK_PKIS: PRKD1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 28.03 % GSK_PKIS: FGR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 28.62 % GSK_PKIS: FLT3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 28.68 % GSK_PKIS: PKC-alpha mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 28.74 % GSK_PKIS: PIM1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 28.96 % GSK_PKIS: DYRK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 29.12 % GSK_PKIS: FER mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 29.47 % GSK_PKIS: PYK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 29.59 % GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 29.77 % GSK_PKIS: PDK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 31.01 % GSK_PKIS: TEC mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 31.24 % GSK_PKIS: KIT (V560G mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 31.27 % GSK_PKIS: KIT mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 31.51 % GSK_PKIS: LYN B (splice variant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 31.57 % GSK_PKIS: KIT (D816V mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 33.49 % GSK_PKIS: YES mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 33.5 % GSK_PKIS: MARK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 33.7 % GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 33.93 % GSK_PKIS: TRKB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 33.99 % GSK_PKIS: ABL1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 34.62 % GSK_PKIS: TTK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 34.95 % GSK_PKIS: PRKG1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 35.28 % GSK_PKIS: LYN A (splice variant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 36.13 % GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 36.28 % GSK_PKIS: IKKE mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 36.47 % GSK_PKIS: BLK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 37.04 % GSK_PKIS: AMPKA1 (A1B1G1) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 37.82 % GSK_PKIS: LTK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 38.81 % GSK_PKIS: MARK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 39.6 % GSK_PKIS: CAMK1D mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 39.76 % GSK_PKIS: PHKG2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 40.01 % GSK_PKIS: AXL mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 40.25 % GSK_PKIS: SGK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 40.25 % GSK_PKIS: LOK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 40.52 % GSK_PKIS: RET mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 41.23 % GSK_PKIS: GRK6 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 41.47 % GSK_PKIS: TRKC mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 42.02 % GSK_PKIS: MST1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 42.35 % GSK_PKIS: MST2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 42.54 % GSK_PKIS: KDR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 43.12 % GSK_PKIS: DYRK1A mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 44.22 % GSK_PKIS: KIT (T6701 mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 44.76 % GSK_PKIS: RET (Y791F mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 44.86 % GSK_PKIS: RSK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 45.26 % GSK_PKIS: MSK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 45.34 % GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 45.58 % GSK_PKIS: p70s6K1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 45.86 % GSK_PKIS: PRKD2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 45.93 % GSK_PKIS: ERBB4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 45.99 % GSK_PKIS: PRKX mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 47.71 % GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 48.38 % GSK_PKIS: PHKG1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 48.43 % GSK_PKIS: MSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 50.12 % GSK_PKIS: MER mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 50.88 % GSK_PKIS: FMS mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 51.64 % GSK_PKIS: AMPKA2 (A2B1G1) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 52.34 % GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 53.09 % GSK_PKIS: EGFR (T790M-L858R mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 53.9 % GSK_PKIS: RSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 53.91 % GSK_PKIS: TBK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 55 % GSK_PKIS: TBK1 % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 55.81 % GSK_PKIS: ROS mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 56 % GSK_PKIS: TBK1 % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 56.44 % GSK_PKIS: SNF1LK2 (QIK) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 57.56 % GSK_PKIS: CAMK2D mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 58.23 % GSK_PKIS: RSK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 58.27 % GSK_PKIS: ALK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 59.38 % GSK_PKIS: SGK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 60.95 % GSK_PKIS: LRRK2 (G2019S mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 63.21 % GSK_PKIS: LRRK2 (G2019S mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 63.49 % GSK_PKIS: FLT4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 63.64 % GSK_PKIS: TNK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 63.73 % GSK_PKIS: TYRO3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 63.83 % GSK_PKIS: SGK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 64.77 % GSK_PKIS: EGFR (L858R mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 65.02 % GSK_PKIS: FLT3 (D835Y mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 65.63 % GSK_PKIS: CHEK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 65.65 % GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 66.67 % GSK_PKIS: PIM3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 66.87 % GSK_PKIS: Aurora-B mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 67.34 % GSK_PKIS: RET (Y791F mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 67.68 % GSK_PKIS: FER mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 68.26 % GSK_PKIS: KDR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 68.33 % GSK_PKIS: PIM2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 68.85 % GSK_PKIS: Aurora-A mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 69.5 % GSK_PKIS: PRKG2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 70.98 % GSK_PKIS: RET (V804L mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 71.27 % GSK_PKIS: BRSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 72.46 % GSK_PKIS: PRKG2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 72.46 % GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 73.27 % GSK_PKIS: PHKG1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 73.45 % GSK_PKIS: RSK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 74.24 % GSK_PKIS: PIM1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 75.39 % GSK_PKIS: KIT (D816V mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 75.62 % GSK_PKIS: HCK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 76.14 % GSK_PKIS: PDK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 77.18 % GSK_PKIS: SNF1LK (SIK) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 77.28 % GSK_PKIS: ARK5 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 77.35 % GSK_PKIS: RET mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 77.6 % GSK_PKIS: MELK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 77.98 % GSK_PKIS: ARK5 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 78.04 % GSK_PKIS: AMPKA1 (A1B1G1) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 78.18 % GSK_PKIS: SNF1LK2 (QIK) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 78.21 % GSK_PKIS: PDGFRB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 78.26 % GSK_PKIS: LTK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 79.09 % GSK_PKIS: FLT3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 79.09 % GSK_PKIS: ROS mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 79.92 % GSK_PKIS: KIT mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 80.09 % GSK_PKIS: RSK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 80.56 % GSK_PKIS: PYK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 81.08 % GSK_PKIS: PDGFRA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 81.16 % GSK_PKIS: CHEK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 81.34 % GSK_PKIS: MINK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 81.97 % GSK_PKIS: RSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 82.08 % GSK_PKIS: RET (V804L mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 82.74 % GSK_PKIS: PIM3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 83.42 % GSK_PKIS: CHEK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 83.52 % GSK_PKIS: PDGFRA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 83.62 % GSK_PKIS: p70s6K1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 84.59 % GSK_PKIS: MAP4K4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 84.79 % GSK_PKIS: MINK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 85.09 % GSK_PKIS: PDGFRB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 86.82 % GSK_PKIS: Aurora-C mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 88 % GSK_PKIS: RSK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 88.37 % GSK_PKIS: MAP4K4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 89.01 % GSK_PKIS: TNK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 92.19 % GSK_PKIS: BRSK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 92.39 % GSK_PKIS: RSK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 92.68 % GSK_PKIS: FLT3 (D835Y mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 93.85 % GSK_PKIS: PDGFRA (V561D mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 94.3 % GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 94.85 % GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 94.93 % GSK_PKIS: BRSK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 96.29 % GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 96.76 % GSK_PKIS: PDGFRA (V561D mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 101.64 % GSK_PKIS: BRSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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