Detailed information for compound 1627614

Basic information

Technical information
  • TDR Targets ID: 1627614
  • Name: N-(2-dimethylaminoethyl)naphtho[1,2-b]quinoli ne-11-carboxamide hydrochloride
  • MW: 379.883 | Formula: C22H22ClN3O
  • H donors: 1 H acceptors: 2 LogP: 4.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)c1cccc2c1nc1c(c2)ccc2c1cccc2)C.Cl
  • InChi: 1S/C22H21N3O.ClH/c1-25(2)13-12-23-22(26)19-9-5-7-16-14-17-11-10-15-6-3-4-8-18(15)20(17)24-21(16)19;/h3-11,14H,12-13H2,1-2H3,(H,23,26);1H
  • InChiKey: KEZIABMGAHTUOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-dimethylaminoethyl)-11-naphtho[1,2-b]quinolinecarboxamide hydrochloride
  • NSC617965

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cation transporter family protein 0.0178 0.0151 0.0349
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0007 0.0054
Schistosoma mansoni acetylcholine receptor subunit beta 0.0087 0.0037 0.0029
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0356 0.0372 0.0365
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0356 0.0372 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0139 0.0101 0.0094
Echinococcus granulosus nAChR subunit 0.0091 0.0043 0.0035
Loa Loa (eye worm) hypothetical protein 0.0091 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.0183 0.0509
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0178 0.0151 0.0349
Echinococcus multilocularis nAChR subunit 0.0178 0.0151 0.0143
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0178 0.0151 0.0147
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0204 0.0183 0.0176
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0087 0.0037 0.0029
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0091 0.0043 0.0076
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0204 0.0183 1
Loa Loa (eye worm) LGC-31 protein 0.0178 0.0151 0.0147
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0178 0.0151 0.0143
Schistosoma mansoni nAChR subunit 0.0178 0.0151 0.0143
Onchocerca volvulus 0.0178 0.0151 0.7789
Loa Loa (eye worm) hypothetical protein 0.0204 0.0183 0.018
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0007 0.0054
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0178 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0091 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0236 0.0222 0.0219
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0356 0.0372 0.1687
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0178 0.0151 0.0147
Brugia malayi Sodium/calcium exchanger protein 0.3235 0.3957 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0048 0.0044
Schistosoma mansoni sodium/calcium exchanger 0.8087 1 1
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0204 0.0183 0.0176
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0178 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Echinococcus granulosus glycine receptor subunit beta 0.0178 0.0151 0.0143
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0731 0.0839 0.4597
Schistosoma mansoni acetylcholine receptor-related 0.0087 0.0037 0.0029
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0139 0.0101 0.0224
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0087 0.0037 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0007 0.0054
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0178 0.0151 0.0143
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0087 0.0037 0.0061
Loa Loa (eye worm) ACC-1 protein 0.0178 0.0151 0.0147
Echinococcus granulosus glycine receptor subunit alpha 1 0.0178 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Schistosoma mansoni nAChR subunit 0.0178 0.0151 0.0143
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0139 0.0101 0.0808
Echinococcus multilocularis glycine receptor subunit beta 0.0178 0.0151 0.0143
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0037 0.0061
Brugia malayi hypothetical protein 0.0087 0.0037 0.0061
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1064 0.1253 1
Onchocerca volvulus 0.0091 0.0043 0.0405
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0052 0.0099
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0091 0.0043 0.0076
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0472 0.0516 0.3911
Schistosoma mansoni hypothetical protein 0.0068 0.0013 0.0005
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1064 0.1253 0.1247
Loa Loa (eye worm) hypothetical protein 0.0775 0.0894 0.0891
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Brugia malayi excitatory GABA receptor EXP-1A 0.0178 0.0151 0.0349
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0091 0.0043 0.0076
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0139 0.0101 0.0094
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0139 0.0101 0.0485
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0178 0.0151 0.0143
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0356 0.0372 0.1687
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0087 0.0037 0.0029
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0204 0.0183 0.0176
Loa Loa (eye worm) hypothetical protein 0.3235 0.3957 0.3955
Onchocerca volvulus 0.0178 0.0151 0.7789
Loa Loa (eye worm) hypothetical protein 0.0091 0.0043 0.0039
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0204 0.0183 0.5
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0087 0.0037 0.0033
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0178 0.0151 0.0143
Loa Loa (eye worm) phosphatidylinositol 3 0.0324 0.0333 0.0329
Loa Loa (eye worm) hypothetical protein 0.0099 0.0052 0.0048
Onchocerca volvulus 0.0091 0.0043 0.0405
Onchocerca volvulus 0.0178 0.0151 0.7789
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0139 0.0101 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0178 0.0151 0.0349
Toxoplasma gondii manganese resistance 1 protein, putative 0.0204 0.0183 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0652 0.0741 0.1845
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0007 0.0054
Loa Loa (eye worm) hypothetical protein 0.0375 0.0395 0.0392
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0204 0.0183 0.0176
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0052 0.0099
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Plasmodium vivax cation/H+ antiporter, putative 0.0204 0.0183 0.1693
Onchocerca volvulus 0.0178 0.0151 0.7789
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1064 0.1253 0.7184
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0087 0.0037 0.0029
Loa Loa (eye worm) hypothetical protein 0.0091 0.0043 0.0039
Schistosoma mansoni nAChR subunit 0.0178 0.0151 0.0143
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0356 0.0372 0.2719
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1064 0.1253 0.7184
Loa Loa (eye worm) hypothetical protein 0.0091 0.0043 0.0039
Schistosoma mansoni na/ca exchanger 0.0204 0.0183 0.0176
Brugia malayi hypothetical protein 0.0087 0.0037 0.0061
Brugia malayi hypothetical protein 0.0087 0.0037 0.0061
Loa Loa (eye worm) acetylcholine receptor protein 0.0087 0.0037 0.0033
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0087 0.0037 0.0061
Echinococcus granulosus nAChR subunit 0.0178 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Echinococcus granulosus glycine receptor subunit alpha 1 0.0178 0.0151 0.0143
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0178 0.0151 0.0143
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0178 0.0151 0.0143
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0178 0.0151 0.0349
Onchocerca volvulus 0.0178 0.0151 0.7789
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0204 0.0183 0.018
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0513 0.0568 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0139 0.0101 0.0094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0178 0.0151 0.0349
Schistosoma mansoni neurotransmitter gated ion channel 0.0087 0.0037 0.0029
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0178 0.0151 0.0349
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0204 0.0183 0.0431
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0139 0.0101 0.0808
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0222 0.0215
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0178 0.0151 0.0143
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0178 0.0151 0.0349
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1064 0.1253 0.1247
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.0183 0.0509
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0178 0.0151 0.0143
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0139 0.0101 0.2589
Echinococcus multilocularis sodium calcium exchanger 0.8087 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0178 0.0151 0.0143
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.0048 0.004
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0087 0.0037 0.0061
Loa Loa (eye worm) hypothetical protein 0.0091 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0565 0.0633 0.063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0178 0.0151 0.0349
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0204 0.0183 0.0176
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0178 0.0151 0.0349
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0044 0.0036
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0847 0.0983 0.7765
Loa Loa (eye worm) hypothetical protein 0.0689 0.0787 0.0784
Loa Loa (eye worm) hypothetical protein 0.0204 0.0183 0.018
Echinococcus multilocularis glycine receptor subunit beta 0.0178 0.0151 0.0143
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0178 0.0151 0.0143
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0178 0.0151 0.0143
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0356 0.0372 0.2719
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0178 0.0151 0.0143
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0087 0.0037 0.0033
Onchocerca volvulus 0.0178 0.0151 0.7789
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0356 0.0372 0.2967
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0178 0.0151 0.0143
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0139 0.0101 0.0094
Loa Loa (eye worm) solute carrier family 8 0.8087 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0324 0.0333 0.2654
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0091 0.0043 0.0076
Brugia malayi Cation transporter family protein 0.0178 0.0151 0.0349
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1064 0.1253 0.1247
Schistosoma mansoni nAChR subunit 0.0178 0.0151 0.0143
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0689 0.0787 0.078
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0689 0.0787 0.1962
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0037 0.0061
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Loa Loa (eye worm) phosphatidylinositol 3 0.0847 0.0983 0.098
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Brugia malayi hypothetical protein 0.0087 0.0037 0.0061
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Schistosoma mansoni nAChR subunit 0.0178 0.0151 0.0143
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0204 0.0183 0.1159
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0178 0.0151 0.0147
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0178 0.0151 0.0143
Loa Loa (eye worm) ACC-1 protein 0.0178 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Schistosoma mansoni neurotransmitter gated ion channel 0.0087 0.0037 0.0029
Trichomonas vaginalis alpha-L-fucosidase, putative 0.1427 0.1705 1
Brugia malayi Cation transporter family protein 0.0178 0.0151 0.0349
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0087 0.0037 0.0029
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0178 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0052 0.0048
Loa Loa (eye worm) hypothetical protein 0.0068 0.0013 0.0009
Echinococcus granulosus glycine receptor subunit beta 0.0178 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Onchocerca volvulus Putative nachr subunit 0.0178 0.0151 0.7789
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0037 0.0061
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0139 0.0101 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1064 0.1253 0.3145
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0178 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0204 0.0183 0.0431
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0178 0.0151 0.0349
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0222 0.0215
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0178 0.0151 0.0143
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0204 0.0183 0.5
Schistosoma mansoni nAChR subunit 0.0087 0.0037 0.0029
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0731 0.0839 0.4597
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0178 0.0151 0.0147
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1064 0.1253 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0178 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0139 0.0101 0.0094
Treponema pallidum hypothetical protein 0.0204 0.0183 0.5
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1064 0.1253 0.7184
Loa Loa (eye worm) hypothetical protein 0.0204 0.0183 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.0183 0.0509
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0178 0.0151 0.0143
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.0048 0.004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1064 0.1253 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0178 0.0151 0.0147
Brugia malayi hypothetical protein 0.0236 0.0222 0.0531
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0178 0.0151 0.0143
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0178 0.0151 0.0143
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0091 0.0043 0.0035
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.0372 0.091
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0178 0.0151 0.0349
Schistosoma mansoni hypothetical protein 0.0204 0.0183 0.0176
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0204 0.0183 0.0176
Loa Loa (eye worm) hypothetical protein 0.0091 0.0043 0.0039
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.0048 0.004
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0178 0.0151 0.0147
Echinococcus multilocularis nAChR subunit 0.0091 0.0043 0.0035
Loa Loa (eye worm) hypothetical protein 0.0652 0.0741 0.0738
Plasmodium falciparum cation/H+ antiporter 0.0204 0.0183 1
Schistosoma mansoni nAChR subunit 0.0087 0.0037 0.0029
Entamoeba histolytica hypothetical protein 0.0847 0.0983 0.7765
Trichomonas vaginalis alpha-L-fucosidase, putative 0.1427 0.1705 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0139 0.0101 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0178 0.0151 0.0349
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0356 0.0372 0.1687
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0178 0.0151 0.0349
Schistosoma mansoni nAChR subunit 0.0178 0.0151 0.0143
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0178 0.0151 0.0349
Schistosoma mansoni transient receptor potential channel 0.0096 0.0048 0.004
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0139 0.0101 0.0094
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1032 0.1214 0.9676
Loa Loa (eye worm) hypothetical protein 0.0091 0.0043 0.0039
Echinococcus granulosus glycine receptor subunit alpha 1 0.0178 0.0151 0.0143
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0139 0.0101 0.0485
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0044 0.0036
Schistosoma mansoni neurotransmitter gated ion channel 0.0091 0.0043 0.0035
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0178 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0178 0.0151 0.0147
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0091 0.0043 0.0035
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033
Schistosoma mansoni nAChR subunit 0.0178 0.0151 0.0143
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0526 0.0584 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0178 0.0151 0.0349
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0689 0.0787 0.078
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0178 0.0151 0.0349
Loa Loa (eye worm) GABA receptor subunit 0.0091 0.0043 0.0039
Brugia malayi hypothetical protein 0.0087 0.0037 0.0061
Loa Loa (eye worm) hypothetical protein 0.0087 0.0037 0.0033

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -7.559 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.474 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.318 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.275 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.091 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.07 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.846 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.