Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Homo sapiens | acid phosphatase 1, soluble | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, non-receptor type 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | protein tyrosine phosphatase | protein tyrosine phosphatase, non-receptor type 2 | 410 aa | 335 aa | 25.7 % |
Mycobacterium tuberculosis | Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) | acid phosphatase 1, soluble | 112 aa | 107 aa | 24.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0156 | 0.2074 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.0249 | 0.4728 | 0.5 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0166 | 0.2343 | 0.2303 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0226 | 0.4062 | 0.7817 |
Entamoeba histolytica | protein kinase, putative | 0.0266 | 0.5196 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0164 | 0.229 | 0.225 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0226 | 0.4062 | 0.7795 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0182 | 0.2811 | 0.5363 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0249 | 0.4728 | 0.47 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0182 | 0.2811 | 0.5363 |
Echinococcus granulosus | nervana 2 | 0.0164 | 0.229 | 0.225 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0053 | 0.0101 |
Echinococcus granulosus | nervana 2 | 0.0164 | 0.229 | 0.225 |
Brugia malayi | Protein kinase domain containing protein | 0.0266 | 0.5196 | 0.517 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0226 | 0.4062 | 0.7817 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0164 | 0.229 | 0.225 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0226 | 0.4062 | 0.7817 |
Trichomonas vaginalis | AGC family protein kinase | 0.0266 | 0.5196 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0266 | 0.5196 | 1 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0226 | 0.4062 | 0.403 |
Entamoeba histolytica | protein kinase, putative | 0.0249 | 0.4728 | 0.909 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0164 | 0.229 | 0.225 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0226 | 0.4062 | 0.403 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0182 | 0.2811 | 0.2773 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0226 | 0.4062 | 0.7817 |
Trichomonas vaginalis | AGC family protein kinase | 0.0102 | 0.0521 | 0.1002 |
Trichomonas vaginalis | AGC family protein kinase | 0.0266 | 0.5196 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0266 | 0.5196 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0266 | 0.5196 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0266 | 0.5196 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0164 | 0.229 | 0.225 |
Trichomonas vaginalis | AGC family protein kinase | 0.0266 | 0.5196 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0434 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0434 | 1 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0266 | 0.5196 | 0.517 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0164 | 0.229 | 0.225 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0226 | 0.4062 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0166 | 0.2343 | 0.2303 |
Onchocerca volvulus | 0.0226 | 0.4062 | 0.5 | |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0226 | 0.4062 | 0.7817 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0166 | 0.2343 | 0.5 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0226 | 0.4062 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0164 | 0.229 | 0.225 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0182 | 0.2811 | 0.2773 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0182 | 0.2811 | 0.2773 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0434 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0182 | 0.2811 | 0.2773 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0434 | 1 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0226 | 0.4062 | 0.7795 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0053 | 0.0101 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0053 | 0.0101 |
Trypanosoma cruzi | Protein kinase B | 0.0182 | 0.2811 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0249 | 0.4728 | 0.47 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0166 | 0.2343 | 0.2303 |
Entamoeba histolytica | protein kinase 2, putative | 0.0166 | 0.2343 | 0.4453 |
Entamoeba histolytica | protein kinase, putative | 0.0266 | 0.5196 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0226 | 0.4062 | 0.7817 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0166 | 0.2343 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0266 | 0.5196 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0182 | 0.2811 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.1 uM | Competitive inhibition of GST-tagged human recombinant PTP1B expressed in Escherichia coli TB1 using p-nitrophenylphosphate as substrate by Line-Weaver Burk plot | ChEMBL. | 22381357 |
IC50 (binding) | = 9.6 uM | Competitive inhibition of GST-tagged human recombinant LMW-PTP IF1 expressed in Escherichia coli TB1 using p-nitrophenylphosphate as substrate by Line-Weaver Burk plot | ChEMBL. | 22381357 |
IC50 (binding) | = 11.6 uM | Competitive inhibition of human recombinant TCPTP using p-nitrophenylphosphate as substrate by Line-Weaver Burk plot | ChEMBL. | 22381357 |
IC50 (binding) | = 17.5 uM | Competitive inhibition of GST-tagged human recombinant LMW-PTP IF2 expressed in Escherichia coli TB1 using p-nitrophenylphosphate as substrate by Line-Weaver Burk plot | ChEMBL. | 22381357 |
Inhibition (binding) | Inhibition of PTP1B in mouse C2C12 cells assessed as increase in intracellular 2-deoxyglucose uptake using [3H]glucose as substrate at 25 uM after 90 mins by scintillation counting | ChEMBL. | 22381357 | |
Inhibition (binding) | Inhibition of PTP1B in mouse C2C12 cells assessed as increase in insulin receptor beta tyrosine phosphorylation at 25 uM | ChEMBL. | 22381357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.