Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0014 | 0.0014 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0014 | 0.0014 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.2141 | 1 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0014 | 0.0014 |
Brugia malayi | Smad1 | 0.0008 | 0.0014 | 0.0014 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.2141 | 1 | 0.5 |
Echinococcus multilocularis | smad | 0.0008 | 0.0014 | 0.0014 |
Onchocerca volvulus | 0.0051 | 0.0213 | 0.0213 | |
Schistosoma mansoni | smad | 0.0008 | 0.0014 | 0.0014 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0014 | 0.0014 |
Echinococcus multilocularis | lysosomal protective protein | 0.2141 | 1 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0014 | 0.0014 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.2141 | 1 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.055 | 0.055 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0014 | 0.0014 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0773 | 0.3594 | 0.3594 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0014 | 0.0014 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0773 | 0.3594 | 0.3594 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0014 | 0.0014 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.1929 | 0.9009 | 0.9009 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.055 | 0.055 |
Echinococcus granulosus | smad | 0.0008 | 0.0014 | 0.0014 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0773 | 0.3594 | 0.3594 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.2141 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.2141 | 1 | 0.5 |
Echinococcus granulosus | lysosomal protective protein | 0.2141 | 1 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0014 | 0.0014 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.2141 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0014 | 0.0014 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0014 | 0.0014 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0014 | 0.0014 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0213 | 0.0213 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0014 | 0.0014 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.2141 | 1 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.2141 | 1 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0347 | 0.1602 | 0.1602 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.1929 | 0.9009 | 0.9009 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0014 | 0.0014 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0014 | 0.0014 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0213 | 0.0213 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0212 | 0.0966 | 0.0966 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0014 | 0.0014 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.2141 | 1 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.2141 | 1 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0347 | 0.1602 | 0.1602 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.055 | 0.055 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.2141 | 1 | 1 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.2141 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.247 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.