Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0113 | 0.0427 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0427 | 0.0427 |
Onchocerca volvulus | 0.0113 | 0.0427 | 0.0219 | |
Schistosoma mansoni | follistatin | 0.0077 | 0.0212 | 0.415 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0212 | 0.0212 |
Echinococcus granulosus | sodium channel protein | 0.0048 | 0.004 | 0.0117 |
Onchocerca volvulus | 0.0113 | 0.0427 | 0.0219 | |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0077 | 0.0212 | 0.0178 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0 | 0.5 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0077 | 0.0212 | 0.0178 |
Loa Loa (eye worm) | agrin synaptic family protein | 0.0077 | 0.0212 | 0.0212 |
Echinococcus multilocularis | expressed protein | 0.0077 | 0.0212 | 0.4518 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0113 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0427 | 0.0427 |
Trypanosoma cruzi | MFS transporter, putative | 0.0113 | 0.0427 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0048 | 0.004 | 0.0117 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0048 | 0.004 | 0.5 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0113 | 0.0427 | 1 |
Echinococcus multilocularis | follistatin | 0.0077 | 0.0212 | 0.4518 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0113 | 0.0427 | 0.0393 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0113 | 0.0427 | 1 |
Schistosoma mansoni | organic anion transporter | 0.0113 | 0.0427 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.0113 | 0.0427 | 0.0219 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0077 | 0.0212 | 0.0178 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0048 | 0.004 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0427 | 0.0427 |
Brugia malayi | hypothetical protein | 0.0113 | 0.0427 | 0.0393 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.1706 | 1 | 1 |
Onchocerca volvulus | 0.0113 | 0.0427 | 0.0219 | |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0113 | 0.0427 | 1 |
Schistosoma mansoni | organic anion transporter | 0.0113 | 0.0427 | 1 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.0077 | 0.0212 | 0.0178 |
Loa Loa (eye worm) | kazal-type serine protease inhibitor domain-containing protein | 0.0077 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0047 | 0.0035 | 0.0035 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0113 | 0.0427 | 0.0393 |
Onchocerca volvulus | 0.0113 | 0.0427 | 0.0219 | |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0113 | 0.0427 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.0113 | 0.0427 | 0.0219 |
Schistosoma mansoni | agrin | 0.0077 | 0.0212 | 0.415 |
Echinococcus granulosus | follistatin | 0.0077 | 0.0212 | 0.4518 |
Echinococcus multilocularis | agrin | 0.0077 | 0.0212 | 0.4518 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0077 | 0.0212 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.1706 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0427 | 0.0427 |
Echinococcus granulosus | agrin | 0.0077 | 0.0212 | 0.4518 |
Onchocerca volvulus | 0.0113 | 0.0427 | 0.0219 | |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0212 | 0.0212 |
Brugia malayi | SPARC precursor | 0.0077 | 0.0212 | 0.0178 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0113 | 0.0427 | 0.0393 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0113 | 0.0427 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0212 | 0.0212 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.