Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Plasmodium falciparum | cation/H+ antiporter | 0.0315 | 0.0212 | 0.5 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0315 | 0.0212 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0102 | 0.004 | 0.0025 |
Echinococcus multilocularis | sodium calcium exchanger | 1.2484 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0102 | 0.004 | 0.0025 |
Schistosoma mansoni | biogenic amine receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.0212 | 0.0212 |
Giardia lamblia | Kinase, PLK | 0.0102 | 0.004 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.0065 | 0.005 |
Schistosoma mansoni | adenoreceptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0315 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0071 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0315 | 0.0212 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0315 | 0.0212 | 0.1014 |
Schistosoma mansoni | opsin-like receptor | 0.0071 | 0.0015 | 0.0015 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0315 | 0.0212 | 0.1014 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0315 | 0.0212 | 0.5 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | biogenic amine receptor | 0.0071 | 0.0015 | 0.0015 |
Trypanosoma brucei | polo-like protein kinase | 0.0102 | 0.004 | 0.5 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | histamine h1 receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide receptor | 0.0071 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | solute carrier family 8 | 1.2484 | 1 | 1 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0315 | 0.0212 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0315 | 0.0212 | 0.1014 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0071 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | myosin xvIII | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | opsin-like receptor | 0.0071 | 0.0015 | 0.0015 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2202 | 0.1729 | 1 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0315 | 0.0212 | 0.0496 |
Brugia malayi | Sodium/calcium exchanger protein | 0.4994 | 0.3975 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.004 | 0.004 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | sodium/calcium exchanger | 1.2484 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0015 | 0.0015 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.0065 | 0.0127 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0071 | 0.0015 | 0.0015 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2202 | 0.1729 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0315 | 0.0212 | 0.0212 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0102 | 0.004 | 0.0064 |
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0071 | 0.0015 | 0.0015 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0102 | 0.004 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.0065 | 0.005 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0315 | 0.0212 | 0.0496 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Treponema pallidum | hypothetical protein | 0.0315 | 0.0212 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | opsin-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | biogenic amine receptor | 0.0071 | 0.0015 | 0.0015 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0102 | 0.004 | 0.0025 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0315 | 0.0212 | 0.5 |
Schistosoma mansoni | na/ca exchanger | 0.0315 | 0.0212 | 0.0212 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide receptor | 0.0071 | 0.0015 | 0.0015 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0102 | 0.004 | 0.5 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0315 | 0.0212 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4994 | 0.3975 | 0.3966 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0071 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.0212 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.0212 | 0.0197 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0102 | 0.004 | 0.1282 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0071 | 0.0015 | 0.0015 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0102 | 0.004 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0071 | 0.0015 | 0.0015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.