Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0015 | 0.0015 |
Plasmodium falciparum | cation/H+ antiporter | 0.0255 | 0.0224 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | solute carrier family 8 | 1.0095 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.067 | 0.0637 | 0.0637 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.0172 | 0.0172 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0255 | 0.0224 | 0.0224 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.067 | 0.0637 | 0.0637 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0019 | 0.0019 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0255 | 0.0224 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0015 | 0.0015 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0255 | 0.0224 | 0.0224 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0086 | 0.0217 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0015 | 0.0015 |
Brugia malayi | Sodium/calcium exchanger protein | 0.4038 | 0.3983 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0255 | 0.0224 | 0.0159 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0255 | 0.0224 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0004 | 0.0004 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0255 | 0.0224 | 0.0224 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0255 | 0.0224 | 0.0224 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0015 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0224 | 0.0224 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0255 | 0.0224 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.0172 | 0.0432 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0015 | 0.0015 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0255 | 0.0224 | 0.0224 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0255 | 0.0224 | 0.0563 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0015 | 0.0015 |
Schistosoma mansoni | na/ca exchanger | 0.0255 | 0.0224 | 0.0224 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0255 | 0.0224 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.067 | 0.0637 | 0.0637 |
Treponema pallidum | hypothetical protein | 0.0255 | 0.0224 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0086 | 0.0086 |
Schistosoma mansoni | hypothetical protein | 0.0255 | 0.0224 | 0.0224 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0255 | 0.0224 | 0.0159 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0086 | 0.0086 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0015 | 0.0015 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0019 | 0.0048 |
Echinococcus multilocularis | sodium calcium exchanger | 1.0095 | 1 | 1 |
Onchocerca volvulus | 0.023 | 0.02 | 0.8908 | |
Schistosoma mansoni | sodium/calcium exchanger | 1.0095 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0004 | 0.001 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0255 | 0.0224 | 0.0224 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1781 | 0.174 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0255 | 0.0224 | 0.5 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0255 | 0.0224 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0224 | 0.0224 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1781 | 0.174 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0015 | 0.0015 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0255 | 0.0224 | 0.0563 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0255 | 0.0224 | 0.0224 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0255 | 0.0224 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4038 | 0.3983 | 0.3983 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0019 | 0.0048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.