TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 413.407 | Formula: C18H15N5O5S
H donors: 4 H acceptors: 5 LogP: 2.93 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: NC(=N)NS(=O)(=O)c1ccc(cc1)/N=N/c1c(O)c(cc2c1cccc2)C(=O)O
InChi: 1S/C18H15N5O5S/c19-18(20)23-29(27,28)12-7-5-11(6-8-12)21-22-15-13-4-2-1-3-10(13)9-14(16(15)24)17(25)26/h1-9,24H,(H,25,26)(H4,19,20,23)/b22-21+
InChiKey: MUOFBLRJLQRVDM-QURGRASLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	GPCR family 2	0.0049	0.0298	0.0402
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.019	0.3133	0.4224
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0402	0.7417	1
Brugia malayi	ecdysteroid receptor	0.0402	0.7417	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.019	0.3133	0.4224
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.019	0.3133	0.4224
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0402	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.0212	0.3592	0.4808
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0099	0.1315	0.1773
Schistosoma mansoni	hypothetical protein	0.0049	0.0298	0.0298
Entamoeba histolytica	hypothetical protein	0.0074	0.0803	0.5
Loa Loa (eye worm)	glutathione reductase	0.0099	0.1305	0.1704
Schistosoma mansoni	nuclear receptor	0.019	0.3133	0.3133
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0402	0.7417	1
Plasmodium falciparum	thioredoxin reductase	0.0099	0.1305	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0402	0.7417	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0251	0.4371	1
Brugia malayi	hypothetical protein	0.019	0.3133	0.4224
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0402	0.7417	1
Toxoplasma gondii	thioredoxin reductase	0.0099	0.1305	1
Trypanosoma brucei	trypanothione reductase	0.0099	0.1305	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.7417	1
Brugia malayi	hypothetical protein	0.0212	0.3592	0.4843
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0226	0.3863	0.8837
Brugia malayi	nuclear hormone receptor	0.0402	0.7417	1
Brugia malayi	Nuclear hormone receptor E75	0.019	0.3133	0.4224
Brugia malayi	hypothetical protein	0.0212	0.3592	0.4843
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0212	0.3592	0.4808
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.019	0.3133	0.3133
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0	0.5
Brugia malayi	nuclear hormone receptor family member nhr-6	0.019	0.3133	0.4224
Schistosoma mansoni	zinc finger protein	0.019	0.3133	0.3133
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Brugia malayi	photoreceptor-specific nuclear receptor	0.0402	0.7417	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0402	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.0212	0.3592	0.4808
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0155	0.2437	0.3285
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0402	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0298	0.0402
Brugia malayi	hypothetical protein	0.019	0.3133	0.4224
Brugia malayi	jmjC domain containing protein	0.0099	0.1315	0.1773
Loa Loa (eye worm)	hypothetical protein	0.0402	0.7417	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0402	0.7417	0.7417
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0226	0.3863	0.8837
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0155	0.2437	0.324
Echinococcus granulosus	Nuclear hormone receptor HR96	0.019	0.3133	0.4224
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Echinococcus granulosus	FTZ F1 alpha	0.0402	0.7417	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0402	0.7417	0.7417
Echinococcus granulosus	ecdysone induced protein 78C	0.0402	0.7417	1
Entamoeba histolytica	hypothetical protein	0.0074	0.0803	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0212	0.3592	0.4843
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0155	0.2437	0.3285
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0402	0.7417	1
Loa Loa (eye worm)	thioredoxin reductase	0.0099	0.1305	0.1704
Schistosoma mansoni	retinoic acid receptor RXR	0.0402	0.7417	0.7417
Loa Loa (eye worm)	hypothetical protein	0.0402	0.7417	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0402	0.7417	0.7417
Trypanosoma cruzi	trypanothione reductase, putative	0.0099	0.1305	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.019	0.3133	0.4224
Brugia malayi	Thioredoxin reductase	0.0099	0.1305	0.1759
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0402	0.7417	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.019	0.3133	0.4185
Brugia malayi	Nuclear hormone receptor E75	0.019	0.3133	0.4224
Echinococcus granulosus	nuclear receptor nhr 48	0.019	0.3133	0.4224
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0402	0.7417	0.7417
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.019	0.3133	0.4224
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Loa Loa (eye worm)	steroid hormone receptor	0.0402	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0402	0.7417	0.7417
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0402	0.7417	0.7417
Treponema pallidum	NADH oxidase	0.0034	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0402	0.7417	1
Schistosoma mansoni	hypothetical protein	0.0106	0.1447	0.1447
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0402	0.7417	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0402	0.7417	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0099	0.1315	0.1773
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0359	0.0419
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.005	0.005
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0803	0.0803
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0	0.5
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0212	0.3592	0.4843
Loa Loa (eye worm)	nuclear receptor NHR-67	0.019	0.3133	0.4185
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.019	0.3133	0.4224
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.0902	0.0902
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0	0.5
Brugia malayi	orphan nuclear receptor NR2E1	0.019	0.3133	0.4224
Loa Loa (eye worm)	hypothetical protein	0.0155	0.2437	0.324
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0803	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1447	0.1896
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0402	0.7417	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0402	0.7417	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0251	0.4371	1
Brugia malayi	Steroid receptor seven-up type 2	0.0402	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.0212	0.3592	0.4808
Loa Loa (eye worm)	hypothetical protein	0.0212	0.3592	0.4808
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0402	0.7417	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.019	0.3133	0.4224
Brugia malayi	steroid hormone receptor	0.0402	0.7417	1
Leishmania major	trypanothione reductase	0.0099	0.1305	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.005	0.005
Schistosoma mansoni	nuclear receptor nhr-48	0.019	0.3133	0.3133
Loa Loa (eye worm)	DR-78	0.019	0.3133	0.4185
Entamoeba histolytica	hypothetical protein	0.0074	0.0803	0.5
Schistosoma mansoni	hypothetical protein	0.0049	0.0298	0.0298
Brugia malayi	hypothetical protein	0.0074	0.0803	0.1083
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0402	0.7417	1
Plasmodium vivax	thioredoxin reductase, putative	0.0099	0.1305	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0402	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.005	0.0067
Plasmodium vivax	glutathione reductase, putative	0.0099	0.1305	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0402	0.7417	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0226	0.3863	0.8837
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0402	0.7417	1
Entamoeba histolytica	hypothetical protein	0.0074	0.0803	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0212	0.3592	0.4843
Brugia malayi	nuclear receptor RXR	0.019	0.3133	0.4224
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Loa Loa (eye worm)	hypothetical protein	0.0402	0.7417	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0298	0.0298
Brugia malayi	conserved hypotetical protein	0.019	0.3133	0.4224
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0099	0.1305	0.1759
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0402	0.7417	1
Schistosoma mansoni	nuclear hormone receptor	0.019	0.3133	0.3133
Schistosoma mansoni	hypothetical protein	0.0074	0.0803	0.0803
Onchocerca volvulus	Bile acid receptor homolog	0.0402	0.7417	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0402	0.7417	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0298	0.0337
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0402	0.7417	1
Schistosoma mansoni	nuclear hormone receptor	0.019	0.3133	0.3133
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.019	0.3133	0.4224
Schistosoma mansoni	hypothetical protein	0.0049	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0212	0.3592	0.4808
Onchocerca volvulus	Protein ultraspiracle homolog	0.0402	0.7417	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0573	0.0711
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0161	0.0217
Loa Loa (eye worm)	nuclear hormone receptor	0.019	0.3133	0.4185
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0402	0.7417	1
Brugia malayi	glutathione reductase	0.0099	0.1305	0.1759
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Loa Loa (eye worm)	MH2 domain-containing protein	0.0125	0.184	0.243
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0402	0.7417	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0402	0.7417	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0	0.5
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0402	0.7417	1
Brugia malayi	tailless protein	0.019	0.3133	0.4224
Echinococcus granulosus	Nuclear hormone receptor HR96	0.019	0.3133	0.4224
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0402	0.7417	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0402	0.7417	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0298	0.0402
Echinococcus granulosus	thioredoxin glutathione reductase	0.0099	0.1305	0.1759
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.005	0.0067
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0402	0.7417	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0226	0.3863	0.8837
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0212	0.3592	0.3592
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0212	0.3592	0.3592
Loa Loa (eye worm)	transcription factor SMAD2	0.0125	0.184	0.243
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0212	0.3592	0.4843
Schistosoma mansoni	thyroid hormone receptor	0.0402	0.7417	0.7417
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0298	0.0402
Echinococcus multilocularis	nuclear receptor nhr 48	0.019	0.3133	0.4224
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0402	0.7417	1
Schistosoma mansoni	coup transcription factor	0.0402	0.7417	0.7417
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0402	0.7417	1
Brugia malayi	jmjC domain containing protein	0.0037	0.005	0.0067
Brugia malayi	nuclear receptor RXR	0.0212	0.3592	0.4843
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0251	0.4371	1
Mycobacterium tuberculosis	Probable reductase	0.0226	0.3863	0.8837
Brugia malayi	nuclear receptor NHR-88	0.019	0.3133	0.4224
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0099	0.1305	0.2985
Brugia malayi	ecdysone receptor	0.019	0.3133	0.4224
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0161	0.0217
Mycobacterium tuberculosis	Probable oxidoreductase	0.0251	0.4371	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0402	0.7417	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0402	0.7417	0.7417
Loa Loa (eye worm)	hypothetical protein	0.0402	0.7417	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0298	0.0402
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0034	0	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0402	0.7417	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0298	0.0402
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0298	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0402	0.7417	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0402	0.7417	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0402	0.7417	1
Onchocerca volvulus		0.0402	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185
Schistosoma mansoni	thyroid hormone receptor	0.0402	0.7417	0.7417
Mycobacterium tuberculosis	Probable dehydrogenase	0.0226	0.3863	0.8837
Echinococcus multilocularis	FTZ F1 alpha	0.0402	0.7417	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0402	0.7417	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0402	0.7417	0.7417
Plasmodium falciparum	glutathione reductase	0.0099	0.1305	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.019	0.3133	0.4224
Brugia malayi	nuclear hormone receptor	0.019	0.3133	0.4224
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0402	0.7417	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0298	0.0402
Schistosoma mansoni	nuclear receptor	0.019	0.3133	0.3133
Schistosoma mansoni	nuclear hormone receptor	0.0402	0.7417	0.7417
Brugia malayi	nuclear receptor NHR-88	0.0402	0.7417	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0106	0.1447	0.1951
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0803	0.1083
Brugia malayi	MH2 domain containing protein	0.0125	0.184	0.2481
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.019	0.3133	0.4224
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0298	0.0337
Brugia malayi	nuclear receptor NHR-67	0.019	0.3133	0.4224
Loa Loa (eye worm)	hypothetical protein	0.019	0.3133	0.4185

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2001122

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1635652