Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0315 | 0.0212 | 0.0212 |
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0102 | 0.004 | 0.0064 |
Schistosoma mansoni | sodium/calcium exchanger | 1.2484 | 1 | 1 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0315 | 0.0212 | 0.0197 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.0065 | 0.0127 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0071 | 0.0015 | 0.0015 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2202 | 0.1729 | 1 |
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0071 | 0.0015 | 0.0015 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2202 | 0.1729 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | myosin xvIII | 0.0071 | 0.0015 | 0.0015 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0315 | 0.0212 | 0.0496 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Brugia malayi | Sodium/calcium exchanger protein | 0.4994 | 0.3975 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.004 | 0.004 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0071 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0102 | 0.004 | 0.1282 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0071 | 0.0015 | 0.0015 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0102 | 0.004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.0212 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0071 | 0.0015 | 0.0015 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0102 | 0.004 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0071 | 0.0015 | 0.0015 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0315 | 0.0212 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4994 | 0.3975 | 0.3966 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0102 | 0.004 | 0.0025 |
Schistosoma mansoni | biogenic amine receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | na/ca exchanger | 0.0315 | 0.0212 | 0.0212 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0315 | 0.0212 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | opsin-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0071 | 0.0015 | 0.0015 |
Treponema pallidum | hypothetical protein | 0.0315 | 0.0212 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0315 | 0.0212 | 0.0496 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0071 | 0.0015 | 0.0015 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0102 | 0.004 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.0065 | 0.005 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0071 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0315 | 0.0212 | 0.0212 |
Schistosoma mansoni | adenoreceptor | 0.0071 | 0.0015 | 0.0015 |
Giardia lamblia | Kinase, PLK | 0.0102 | 0.004 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.0065 | 0.005 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.0212 | 0.0212 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0102 | 0.004 | 0.0025 |
Schistosoma mansoni | biogenic amine receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0102 | 0.004 | 0.0025 |
Echinococcus multilocularis | sodium calcium exchanger | 1.2484 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Plasmodium falciparum | cation/H+ antiporter | 0.0315 | 0.0212 | 0.5 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0315 | 0.0212 | 0.5 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0315 | 0.0212 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0315 | 0.0212 | 0.1014 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0315 | 0.0212 | 0.0197 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | histamine h1 receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide receptor | 0.0071 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | solute carrier family 8 | 1.2484 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0102 | 0.004 | 0.5 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | biogenic amine receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuropeptide receptor | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0015 | 0.0015 |
Schistosoma mansoni | amine GPCR | 0.0071 | 0.0015 | 0.0015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0315 | 0.0212 | 0.1014 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0315 | 0.0212 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0071 | 0.0015 | 0.0015 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0315 | 0.0212 | 0.0197 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0315 | 0.0212 | 0.1014 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0071 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0315 | 0.0212 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.283 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.147 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.