TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 414.448 | Formula: C23H26O7
H donors: 1 H acceptors: 3 LogP: 2.93 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1O)CC(=O)OC/C(=C\COCc1ccccc1)/COC(=O)C
InChi: 1S/C23H26O7/c1-17(24)29-15-20(10-11-28-14-18-6-4-3-5-7-18)16-30-23(26)13-19-8-9-21(25)22(12-19)27-2/h3-10,12,25H,11,13-16H2,1-2H3/b20-10-
InChiKey: WHHHPGQYADCPQJ-JMIUGGIZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0021	0.0026	0.0103
Loa Loa (eye worm)	hypothetical protein	0.017	0.1251	0.5014
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0322	0.2495	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0021	0.0026	0.0098
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0322	0.2495	1
Brugia malayi	nuclear hormone receptor	0.0322	0.2495	0.3451
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.0683	0.2737
Brugia malayi	hypothetical protein	0.017	0.1251	0.173
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0322	0.2495	0.3451
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.017	0.1251	0.5014
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0322	0.2495	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0021	0.0026	0.0098
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0021	0.0026	0.0098
Brugia malayi	ecdysteroid receptor	0.0322	0.2495	0.3451
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0322	0.2495	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0152	0.1102	0.4416
Brugia malayi	nuclear hormone receptor	0.0152	0.1102	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0017	0	0.5
Brugia malayi	nuclear receptor RXR	0.0152	0.1102	0.1524
Schistosoma mansoni	thyroid hormone receptor	0.0322	0.2495	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0322	0.2495	0.3451
Schistosoma mansoni	nuclear hormone receptor	0.0322	0.2495	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0322	0.2495	0.3451
Brugia malayi	hypothetical protein	0.0152	0.1102	0.1524
Echinococcus multilocularis		0.0021	0.0026	0.0103
Schistosoma mansoni	hypothetical protein	0.0032	0.0119	0.0476
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0322	0.2495	1
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0021	0.0026	0.0098
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0119	0.0476
Brugia malayi	Nuclear hormone receptor E75	0.0152	0.1102	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0119	0.0164
Brugia malayi	SWIRM domain containing protein	0.0021	0.0026	0.0035
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0322	0.2495	1
Brugia malayi	Nuclear hormone receptor E75	0.0152	0.1102	0.1524
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0322	0.2495	0.3451
Brugia malayi	nuclear receptor NHR-67	0.0152	0.1102	0.1524
Echinococcus granulosus	ecdysone induced protein 78C	0.0322	0.2495	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0322	0.2495	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0322	0.2495	1
Brugia malayi	nuclear receptor NHR-88	0.0322	0.2495	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2495	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.1251	0.5014
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0322	0.2495	1
Brugia malayi	Nuclear hormone receptor-like 1	0.017	0.1251	0.173
Schistosoma mansoni	amine oxidase	0.0021	0.0026	0.0103
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0593	0.2378
Schistosoma mansoni	hypothetical protein	0.0069	0.0422	0.169
Schistosoma mansoni	amine oxidase	0.0021	0.0026	0.0103
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0593	0.2378
Brugia malayi	hypothetical protein	0.0152	0.1102	0.1524
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0322	0.2495	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0021	0.0026	0.0103
Brugia malayi	photoreceptor-specific nuclear receptor	0.0322	0.2495	0.3451
Entamoeba histolytica	tubulin alpha chain, putative	0.0017	0	0.5
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0017	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0152	0.1102	0.4416
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0322	0.2495	0.3451
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0593	0.2378
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0152	0.1102	0.4416
Schistosoma mansoni	nuclear hormone receptor	0.0152	0.1102	0.4416
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0322	0.2495	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0322	0.2495	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0322	0.2495	1
Brugia malayi	nuclear receptor NHR-88	0.0152	0.1102	0.1524
Brugia malayi	nuclear receptor RXR	0.017	0.1251	0.173
Schistosoma mansoni	hypothetical protein	0.0032	0.0119	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Schistosoma mansoni	nuclear receptor	0.0152	0.1102	0.4416
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0339	0.2628	1
Toxoplasma gondii	RNA-directed DNA polymerase	0.0339	0.2628	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0152	0.1102	0.1079
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0322	0.2495	1
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0339	0.2628	1
Brugia malayi	hypothetical protein	0.0021	0.0026	0.0035
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.017	0.1251	0.173
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0021	0.0026	0.0103
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0152	0.1102	0.4416
Brugia malayi	Telomerase reverse transcriptase	0.0901	0.723	1
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2495	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0119	0.0476
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0026	0.0098
Schistosoma mansoni	hypothetical protein	0.0032	0.0119	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2495	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0026	0.0103
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0322	0.2495	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0593	0.2378
Schistosoma mansoni	coup transcription factor	0.0322	0.2495	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.0683	0.0944
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0593	0.2378
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.017	0.1251	0.5014
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0017	0	0.5
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0291	0.2241	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0322	0.2495	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0152	0.1102	0.4416
Brugia malayi	Nuclear hormone receptor-like 1	0.0322	0.2495	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Echinococcus granulosus	thyroid hormone receptor alpha	0.0152	0.1102	0.4416
Loa Loa (eye worm)	hypothetical protein	0.017	0.1251	0.5014
Schistosoma mansoni	nuclear receptor nhr-48	0.0152	0.1102	0.4416
Brugia malayi	nuclear hormone receptor family member odr-7	0.0152	0.1102	0.1524
Plasmodium falciparum	protoporphyrinogen oxidase	0.0021	0.0026	0.0098
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0119	0.0476
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0021	0.0026	0.0103
Onchocerca volvulus		0.0322	0.2495	0.2475
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0152	0.1102	0.4416
Loa Loa (eye worm)	hypothetical protein	0.017	0.1251	0.5014
Schistosoma mansoni	retinoic acid receptor RXR	0.0322	0.2495	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Echinococcus multilocularis	ecdysone induced protein 78C	0.0322	0.2495	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0322	0.2495	0.3451
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0026	0.0103
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0152	0.1102	0.4416
Onchocerca volvulus		0.0152	0.1102	0.1079
Brugia malayi	orphan nuclear receptor NR2E1	0.0152	0.1102	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2495	1
Brugia malayi	tailless protein	0.0152	0.1102	0.1524
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0119	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2495	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0017	0	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0119	0.0476
Brugia malayi	ecdysone receptor	0.0152	0.1102	0.1524
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0322	0.2495	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0026	0.0103
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0291	0.2241	1
Leishmania major	UDP-galactopyranose mutase	0.0021	0.0026	0.0098
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0021	0.0026	0.0103
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0593	0.2378
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.017	0.1251	0.5014
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0322	0.2495	1
Echinococcus granulosus	GPCR family 2	0.0032	0.0119	0.0476
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0593	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0119	0.0476
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0119	0.0164
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0152	0.1102	0.4416
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0322	0.2495	0.3451
Brugia malayi	amine oxidase, flavin-containing family protein	0.0021	0.0026	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0322	0.2495	0.3451
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0021	0.0026	0.5
Loa Loa (eye worm)	hypothetical protein	0.017	0.1251	0.5014
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0271	0.2074	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0422	0.0583
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0322	0.2495	0.2475
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.017	0.1251	0.5014
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0322	0.2495	1
Giardia lamblia	Telomerase catalytic subunit	0.0339	0.2628	1
Onchocerca volvulus		0.0152	0.1102	0.1079
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0152	0.1102	0.4416
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0322	0.2495	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0322	0.2495	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0152	0.1102	0.4416
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0021	0.0026	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0026	0.0103
Brugia malayi	Steroid receptor seven-up type 2	0.0322	0.2495	0.3451
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0322	0.2495	1
Schistosoma mansoni	nuclear hormone receptor	0.0152	0.1102	0.4416
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0322	0.2495	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Echinococcus granulosus	FTZ F1 alpha	0.0322	0.2495	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0322	0.2495	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.0683	0.0944
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0322	0.2495	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.017	0.1251	0.5014
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0152	0.1102	0.1524
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0322	0.2495	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Schistosoma mansoni	hypothetical protein	0.0032	0.0119	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2495	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1102	0.4416
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0422	0.169
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0021	0.0026	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0683	0.2737
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0322	0.2495	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0593	0.2378
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0339	0.2628	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0152	0.1102	0.4416
Plasmodium falciparum	telomerase reverse transcriptase	0.0339	0.2628	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0152	0.1102	0.4416
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0476
Trypanosoma brucei	telomerase reverse transcriptase	0.0339	0.2628	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0322	0.2495	0.2475
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0152	0.1102	0.4416
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0152	0.1102	0.4416
Schistosoma mansoni	zinc finger protein	0.0152	0.1102	0.4416
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0322	0.2495	1
Schistosoma mansoni	thyroid hormone receptor	0.0322	0.2495	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0322	0.2495	0.3451
Loa Loa (eye worm)	nuclear hormone receptor	0.0152	0.1102	0.4416
Leishmania major	telomerase reverse transcriptase, putative	0.0339	0.2628	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0322	0.2495	1
Loa Loa (eye worm)	DR-78	0.0152	0.1102	0.4416
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0322	0.2495	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0026	0.0103
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0021	0.0026	0.0098
Brugia malayi	hypothetical protein	0.017	0.1251	0.173
Brugia malayi	conserved hypotetical protein	0.0152	0.1102	0.1524
Schistosoma mansoni	RAR-like nuclear receptor	0.0322	0.2495	1
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0021	0.0026	0.0098
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0593	0.2378
Toxoplasma gondii	histone lysine-specific demethylase	0.0021	0.0026	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0322	0.2495	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2495	1
Onchocerca volvulus	Bile acid receptor homolog	0.0322	0.2495	0.2475
Loa Loa (eye worm)	steroid hormone receptor	0.0322	0.2495	1
Brugia malayi	steroid hormone receptor	0.0322	0.2495	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0026	0.0103
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0026	0.0098
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0322	0.2495	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0152	0.1102	0.1079
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0152	0.1102	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2495	1
Schistosoma mansoni	nuclear receptor	0.0152	0.1102	0.4416
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0021	0.0026	0.0098
Echinococcus multilocularis	FTZ F1 alpha	0.0322	0.2495	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0152	0.1102	0.4416

Activities

Activity type	Activity value	Assay description	Source	Reference
Cation influx (functional)		Cation influx relative to capsaicin (CAP) in cultured neonatal rat dorsal root ganglia (No response)	ChEMBL.	10571146
Cation influx (functional)	0	Cation influx relative to capsaicin (CAP) in cultured neonatal rat dorsal root ganglia (No response)	ChEMBL.	10571146
Ki (binding)	> 100 uM	In vitro binding affinity towards vanilloid receptor by [3H]-RTX displacement.	ChEMBL.	10571146
Ki (binding)	> 100 uM	In vitro binding affinity towards vanilloid receptor by [3H]-RTX displacement.	ChEMBL.	10571146

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL316472

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 163702