Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Sodium/calcium exchanger protein | 0.5196 | 0.3981 | 1 |
Treponema pallidum | hypothetical protein | 0.0328 | 0.0221 | 0.5 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0328 | 0.0221 | 0.0221 |
Schistosoma mansoni | na/ca exchanger | 0.0328 | 0.0221 | 0.0221 |
Plasmodium falciparum | cation/H+ antiporter | 0.0328 | 0.0221 | 0.5 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0328 | 0.0221 | 0.0221 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0328 | 0.0221 | 0.5 |
Echinococcus multilocularis | sodium calcium exchanger | 1.2988 | 1 | 1 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0328 | 0.0221 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.0221 | 0.0221 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0328 | 0.0221 | 0.0221 |
Brugia malayi | MH2 domain containing protein | 0.0108 | 0.0051 | 0.0129 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0328 | 0.0221 | 0.0556 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0328 | 0.0221 | 0.0221 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0328 | 0.0221 | 0.0221 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0328 | 0.0221 | 0.5 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0328 | 0.0221 | 0.0221 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0328 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.0221 | 0.0221 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0328 | 0.0221 | 0.5 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0328 | 0.0221 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0108 | 0.0051 | 0.0051 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0108 | 0.0051 | 0.0051 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2291 | 0.1738 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0328 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.5196 | 0.3981 | 0.3981 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.0221 | 0.0221 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0328 | 0.0221 | 0.0556 |
Schistosoma mansoni | sodium/calcium exchanger | 1.2988 | 1 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2291 | 0.1738 | 1 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0328 | 0.0221 | 0.5 |
Loa Loa (eye worm) | solute carrier family 8 | 1.2988 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.879 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.686 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.552 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.428 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.39 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.327 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.103 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.717 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.514 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.