Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.4604 | 0.4604 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0123 | 0.0123 |
Toxoplasma gondii | hexokinase | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.4604 | 0.4604 |
Brugia malayi | hexokinase type II | 0.0031 | 0.0123 | 0.0123 |
Schistosoma mansoni | hexokinase | 0.0096 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5396 | 0.5396 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 48 nM | Activation of human recombinant glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH assessed as glucose 6-phosphate formation by spectrometric analysis | ChEMBL. | 22459213 |
FC (binding) | = 2.1 | Activation of human recombinant glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH assessed as glucose 6-phosphate formation by spectrometric analysis relative to control | ChEMBL. | 22459213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.