Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0132 | 0.0841 | 0.0945 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0247 | 0.275 | 0.3415 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0247 | 0.275 | 0.3937 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0684 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0421 | 0.5644 | 0.7008 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0196 | 0.1909 | 0.2147 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0684 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0618 | 0.8895 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0684 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 0.8895 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0684 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0421 | 0.5644 | 0.6346 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0684 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0132 | 0.0841 | 0.0945 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0684 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0421 | 0.5644 | 0.6346 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0841 | 0.0945 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0452 | 0.6144 | 0.8796 |
Loa Loa (eye worm) | glutamate receptor | 0.0502 | 0.6985 | 0.7853 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0502 | 0.6985 | 1 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0081 | 0 | 0.5 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0081 | 0 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0684 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0618 | 0.8895 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0132 | 0.0841 | 0.1204 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0567 | 0.8054 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.