Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type V, alpha subunit | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Cystatin B Stefin B | 0.0053 | 0.4543 | 0.4543 |
Brugia malayi | cystatin | 0.0053 | 0.4543 | 1 |
Echinococcus multilocularis | proteinase inhibitor I25, cystatin | 0.0053 | 0.4543 | 0.4543 |
Schistosoma mansoni | cystatin B | 0.0053 | 0.4543 | 0.9508 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.4543 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.005 | 0.4231 | 0.4231 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.005 | 0.4231 | 0.9313 |
Loa Loa (eye worm) | cysteine protease inhibitor | 0.0053 | 0.4543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.4543 | 1 |
Trichomonas vaginalis | Clan IH, family I25, phytocystatin-like peptidase inhibitor | 0.0053 | 0.4543 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0094 | 1 | 1 |
Brugia malayi | cystatin | 0.0053 | 0.4543 | 1 |
Onchocerca volvulus | 0.0053 | 0.4543 | 0.5 | |
Loa Loa (eye worm) | cystatin-type cysteine proteinase inhibitor CPI-1 | 0.0053 | 0.4543 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.4779 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.4543 | 0.9508 |
Echinococcus granulosus | proteinase inhibitor I25 cystatin | 0.0053 | 0.4543 | 0.4543 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0094 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3445 | 0.7582 |
Onchocerca volvulus | 0.0053 | 0.4543 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.4543 | 0.9508 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.005 | 0.4231 | 0.9313 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.005 | 0.4231 | 0.4231 |
Onchocerca volvulus | 0.0053 | 0.4543 | 0.5 | |
Onchocerca volvulus | 0.0053 | 0.4543 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.4779 | 1 |
Onchocerca volvulus | 0.0053 | 0.4543 | 0.5 | |
Brugia malayi | cystatin-type cysteine proteinase inhibitor CPI-2, putative | 0.0053 | 0.4543 | 1 |
Loa Loa (eye worm) | cystatin | 0.0053 | 0.4543 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0053 | 0.4543 | 1 |
Echinococcus multilocularis | Cystatin B (Stefin B) | 0.0053 | 0.4543 | 0.4543 |
Onchocerca volvulus | 0.0053 | 0.4543 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.62 uM | Antagonist activity at human partially inactivated NaV 1.7 channel expressed in HEK293 cells by PatchXpress voltage patch clamp assay | ChEMBL. | 22306122 |
IC50 (functional) | = 0.72 uM | Antagonist activity at human partially inactivated NaV 1.5 channel expressed in HEK293 cells by PatchXpress voltage patch clamp assay | ChEMBL. | 22306122 |
Ki (binding) | = 2.9 uM | Displacement of dofetilide from human ERG | ChEMBL. | 22306122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.