Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type V, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.005 | 0.4231 | 0.9263 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.005 | 0.4231 | 0.4231 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.4568 | 1 |
Schistosoma mansoni | cystatin B | 0.0053 | 0.4568 | 0.9559 |
Echinococcus multilocularis | proteinase inhibitor I25, cystatin | 0.0053 | 0.4568 | 0.4568 |
Brugia malayi | cystatin | 0.0053 | 0.4568 | 1 |
Echinococcus granulosus | Cystatin B Stefin B | 0.0053 | 0.4568 | 0.4568 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.4568 | 0.9559 |
Echinococcus granulosus | proteinase inhibitor I25 cystatin | 0.0053 | 0.4568 | 0.4568 |
Loa Loa (eye worm) | cystatin-type cysteine proteinase inhibitor CPI-1 | 0.0053 | 0.4568 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.4779 | 1 |
Onchocerca volvulus | 0.0053 | 0.4568 | 0.5 | |
Brugia malayi | cystatin | 0.0053 | 0.4568 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0094 | 1 | 1 |
Trichomonas vaginalis | Clan IH, family I25, phytocystatin-like peptidase inhibitor | 0.0053 | 0.4568 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.4568 | 1 |
Loa Loa (eye worm) | cysteine protease inhibitor | 0.0053 | 0.4568 | 1 |
Brugia malayi | cystatin-type cysteine proteinase inhibitor CPI-2, putative | 0.0053 | 0.4568 | 1 |
Onchocerca volvulus | 0.0053 | 0.4568 | 0.5 | |
Onchocerca volvulus | 0.0053 | 0.4568 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.4779 | 1 |
Onchocerca volvulus | 0.0053 | 0.4568 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.005 | 0.4231 | 0.4231 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.005 | 0.4231 | 0.9263 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0094 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.4568 | 0.9559 |
Onchocerca volvulus | 0.0053 | 0.4568 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3445 | 0.7541 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0094 | 1 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.4568 | 0.5 | |
Echinococcus multilocularis | Cystatin B (Stefin B) | 0.0053 | 0.4568 | 0.4568 |
Loa Loa (eye worm) | cystatin | 0.0053 | 0.4568 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0053 | 0.4568 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.03 uM | Antagonist activity at human NaV1.7 channel by patchXpress assay | ChEMBL. | 22318156 |
IC50 (functional) | = 0.08 uM | Antagonist activity at human NaV1.5 channel by patchXpress assay | ChEMBL. | 22318156 |
Ki (binding) | = 0.68 uM | Displacement of dofetilide from human ERG | ChEMBL. | 22318156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.