Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | semaphorin 5B | 0.0246 | 0.307 | 0.2956 |
Schistosoma mansoni | semaphorin 5-related | 0.0246 | 0.307 | 0.368 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0.0944 | 0.5 |
Schistosoma mansoni | plexin | 0.0342 | 0.4558 | 0.5464 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.307 | 0.2956 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.307 | 0.2956 |
Schistosoma mansoni | plexin | 0.0588 | 0.8342 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0944 | 0.0795 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0269 | 0.0109 |
Echinococcus granulosus | roundabout 2 | 0.0069 | 0.0353 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0944 | 0.0795 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0.0944 | 0.5 |
Onchocerca volvulus | 0.0588 | 0.8342 | 1 | |
Echinococcus granulosus | semaphorin 5B | 0.0246 | 0.307 | 0.2956 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.307 | 0.2956 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0057 | 0.0162 | 0.0194 |
Echinococcus multilocularis | plexin a4 | 0.0696 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0256 | 0.3226 | 0.3115 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0142 | 0.1467 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0.0944 | 0.5 |
Echinococcus granulosus | transcription factor collier | 0.0108 | 0.0944 | 0.0795 |
Brugia malayi | DNA-binding protein LAG-1 | 0.0108 | 0.0944 | 0.0795 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0944 | 0.0795 |
Echinococcus multilocularis | hypothetical protein | 0.0246 | 0.307 | 0.2956 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0667 | 0.9548 | 0.954 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0.0944 | 0.5 |
Brugia malayi | hypothetical protein | 0.0246 | 0.307 | 0.2956 |
Schistosoma mansoni | cell adhesion molecule | 0.0064 | 0.0269 | 0.0322 |
Echinococcus multilocularis | exocyst complex component 2 | 0.0108 | 0.0944 | 0.0795 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0057 | 0.0162 | 0.0194 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0108 | 0.0944 | 0.5 |
Onchocerca volvulus | 0.0246 | 0.307 | 0.2038 | |
Loa Loa (eye worm) | plexin A | 0.0696 | 1 | 1 |
Brugia malayi | Probable exocyst complex component Sec5 | 0.0108 | 0.0944 | 0.0795 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.8342 | 0.8315 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0108 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0353 | 0.0194 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0108 | 0.0944 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.0944 | 0.1132 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0246 | 0.307 | 0.2956 |
Echinococcus granulosus | twitchin | 0.0062 | 0.0246 | 0.0085 |
Echinococcus multilocularis | neuroglian | 0.0062 | 0.0246 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.0944 | 0.1132 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0256 | 0.3226 | 0.3115 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0246 | 0.307 | 0.2956 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0198 | 0.2328 | 0.0916 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0142 | 0.1467 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0353 | 0.0194 |
Schistosoma mansoni | fibrocystin l | 0.0108 | 0.0944 | 0.1132 |
Echinococcus multilocularis | roundabout 2 | 0.0069 | 0.0353 | 0.0194 |
Brugia malayi | IPT/TIG domain containing protein | 0.0108 | 0.0944 | 0.0795 |
Brugia malayi | hypothetical protein | 0.0246 | 0.307 | 0.2956 |
Echinococcus granulosus | plexin a4 | 0.0696 | 1 | 1 |
Brugia malayi | Sema domain containing protein | 0.0246 | 0.307 | 0.2956 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.4558 | 0.4469 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.307 | 0.2956 |
Schistosoma mansoni | nephrin | 0.0062 | 0.0246 | 0.0294 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.307 | 0.2956 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0944 | 0.0795 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.4558 | 0.5464 |
Echinococcus granulosus | exocyst complex component 2 | 0.0108 | 0.0944 | 0.0795 |
Schistosoma mansoni | hypothetical protein | 0.0246 | 0.307 | 0.368 |
Schistosoma mansoni | vesicular amine transporter | 0.0057 | 0.0162 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.307 | 0.2956 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0108 | 0.0944 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0246 | 0.307 | 0.368 |
Brugia malayi | Sema domain containing protein | 0.0246 | 0.307 | 0.2956 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0108 | 0.0944 | 0.5 |
Echinococcus granulosus | semaphorin 1A | 0.0246 | 0.307 | 0.2956 |
Echinococcus granulosus | neuroglian | 0.0062 | 0.0246 | 0.0085 |
Echinococcus multilocularis | transcription factor collier | 0.0108 | 0.0944 | 0.0795 |
Brugia malayi | Plexin repeat family protein | 0.0588 | 0.8342 | 0.8315 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0064 | 0.0269 | 0.0109 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 425 nM l-1 | Inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor in rat brain cortical membranes. | ChEMBL. | 9288174 |
Ki (binding) | = 425 nM l-1 | Inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor in rat brain cortical membranes. | ChEMBL. | 9288174 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.