Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Homo sapiens | farnesyltransferase, CAAX box, beta | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 150 nM | In vitro inhibition of farnesyl transferase using purified recombinant human enzyme | ChEMBL. | 11520202 |
IC50 (binding) | = 150 nM | In vitro inhibition of farnesyl transferase using purified recombinant human enzyme | ChEMBL. | 11520202 |
IC50 (binding) | > 50000 nM | Inhibitory concentration of geranylgeranyl-protein transferase type I | ChEMBL. | 11520202 |
IC50 (binding) | > 50000 nM | Inhibitory concentration of geranylgeranyl-protein transferase type I | ChEMBL. | 11520202 |
IP (binding) | = 21000 nM | Inhibition of [35S]-MK-499 binding to human ERG potassium channel stably expressed in HEK293 cells | ChEMBL. | 11520202 |
IP (binding) | = 21000 nM | Inhibition of [35S]-MK-499 binding to human ERG potassium channel stably expressed in HEK293 cells | ChEMBL. | 11520202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.