Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 7 | Starlite/ChEMBL | No references |
Homo sapiens | cell division cycle 7 | Starlite/ChEMBL | No references |
Homo sapiens | cyclin-dependent kinase 9 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 7 | 346 aa | 311 aa | 32.5 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 9 | 372 aa | 313 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0511 | 1 | 1 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0103 | 0.0857 | 0.0764 |
Echinococcus multilocularis | cyclin dependent kinase 7 | 0.0094 | 0.0645 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.007 | 0.0102 | 0.5 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.007 | 0.0102 | 0.1577 |
Giardia lamblia | Kinase, CDC7 | 0.007 | 0.0102 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0113 | 0.1079 | 0.0987 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0511 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0645 | 0.0548 |
Loa Loa (eye worm) | CMGC/CDK/CDK7 protein kinase | 0.0094 | 0.0645 | 0.0548 |
Echinococcus granulosus | cyclin dependent kinase 7 | 0.0094 | 0.0645 | 1 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0511 | 1 | 1 |
Onchocerca volvulus | 0.0511 | 1 | 1 | |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0511 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0113 | 0.1079 | 0.5 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.007 | 0.0102 | 0.1577 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0511 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1079 | 0.0987 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0645 | 0.0548 |
Trichomonas vaginalis | CMGC family protein kinase | 0.007 | 0.0102 | 0.5 |
Toxoplasma gondii | dgat2l1-prov protein | 0.0511 | 1 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0113 | 0.1079 | 0.0987 |
Trichomonas vaginalis | CMGC family protein kinase | 0.007 | 0.0102 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | > 5.6 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK7 | ChEMBL. | No reference |
Ki (functional) | > 5.6 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK9 | ChEMBL. | No reference |
Ki (functional) | = 7 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.