Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 7 | Starlite/ChEMBL | No references |
Homo sapiens | cyclin-dependent kinase 7 | Starlite/ChEMBL | No references |
Homo sapiens | cyclin-dependent kinase 9 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 7 | 346 aa | 311 aa | 32.5 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 9 | 372 aa | 313 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | dgat2l1-prov protein | 0.0511 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.007 | 0.0102 | 0.5 |
Giardia lamblia | Kinase, CDC7 | 0.007 | 0.0102 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0645 | 0.0548 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0511 | 1 | 1 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.007 | 0.0102 | 0.1577 |
Echinococcus granulosus | cyclin dependent kinase 7 | 0.0094 | 0.0645 | 1 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0511 | 1 | 1 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0511 | 1 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0113 | 0.1079 | 0.0987 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0511 | 1 | 1 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0511 | 1 | 1 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.007 | 0.0102 | 0.1577 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0103 | 0.0857 | 0.0764 |
Trichomonas vaginalis | CMGC family protein kinase | 0.007 | 0.0102 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0645 | 0.0548 |
Onchocerca volvulus | 0.0511 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1079 | 0.0987 |
Loa Loa (eye worm) | CMGC/CDK/CDK7 protein kinase | 0.0094 | 0.0645 | 0.0548 |
Echinococcus multilocularis | cyclin dependent kinase 7 | 0.0094 | 0.0645 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.007 | 0.0102 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0113 | 0.1079 | 0.5 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0511 | 1 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0113 | 0.1079 | 0.0987 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | > 5.6 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK7 | ChEMBL. | No reference |
Ki (functional) | > 5.6 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK9 | ChEMBL. | No reference |
Ki (functional) | = 7 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.