Detailed information for compound 1652067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 562.084 | Formula: C25H32ClN7O4S
  • H donors: 3 H acceptors: 4 LogP: 2.04 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: N=C/C(=C(\C(=O)Nc1cccc(c1)Cl)/OCC1(C)CC1)/N1CCN(CC1)S(=O)(=O)NCc1ccnc(c1)N
  • InChi: 1S/C25H32ClN7O4S/c1-25(6-7-25)17-37-23(24(34)31-20-4-2-3-19(26)14-20)21(15-27)32-9-11-33(12-10-32)38(35,36)30-16-18-5-8-29-22(28)13-18/h2-5,8,13-15,27,30H,6-7,9-12,16-17H2,1H3,(H2,28,29)(H,31,34)/b23-21-,27-15?
  • InChiKey: RPGYKKMLMMHOJA-RVUSSSHYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans similar to S. cerevisiae FKS3 (YMR306W) 1,3-beta glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Toxoplasma gondii 1,3-beta-glucan synthase component protein Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans C terminus of glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans N terminus of glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans C terminus of glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Neospora caninum hypothetical protein Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans N terminus of glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0212 0.0292
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0068 0.0863 0.0863
Loa Loa (eye worm) calpain family protein 1 0.0045 0.0525 0.1357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.014 0.0362
Loa Loa (eye worm) steroid hormone receptor 0.002 0.014 0.0362
Treponema pallidum NADH oxidase 0.0016 0.009 0.5
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.009 0.5
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0132 0.0101
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1467 0.6628
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0132 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1467 0.6628
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.014 0.014
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0064 0.0813 0.2103
Brugia malayi calpain family protein 1 0.0064 0.0813 0.2103
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0132 0.0101
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0776 0.0776
Loa Loa (eye worm) calpain 0.0019 0.0132 0.0341
Brugia malayi CXXC zinc finger family protein 0.0029 0.0276 0.0713
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0132 0.0101
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0132 0.0132
Plasmodium vivax glutathione reductase, putative 0.0047 0.0555 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0212 0.0336
Trypanosoma brucei trypanothione reductase 0.0047 0.0555 0.1117
Echinococcus multilocularis FTZ F1 alpha 0.002 0.014 0.014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.014 0.0362
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0212 0.0292
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0555 0.1117
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0776 0.2006
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0212 0.2615
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0212 0.0547
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.014 0.014
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0132 0.0101
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.014 0.014
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0132 0.0101
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.009 0.5
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.009 0.0233
Brugia malayi hypothetical protein 0.0016 0.0081 0.021
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0362
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0132 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.2168 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0776 0.0776
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0132 0.0101
Schistosoma mansoni calpain (C02 family) 0.0019 0.0132 0.0132
Loa Loa (eye worm) calpain family protein 1 0.0064 0.0813 0.2103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.014 0.0362
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.076 0.076
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.009 0.009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0132 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0362
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.014 0.014
Echinococcus granulosus tar DNA binding protein 0.0062 0.0776 0.0776
Onchocerca volvulus 0.0029 0.0276 0.3532
Schistosoma mansoni glutaminase 0.0267 0.3867 0.3867
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0863 0.0863
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.014 0.014
Mycobacterium tuberculosis Probable reductase 0.0108 0.1467 0.6628
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0555 0.1436
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0555 0.0555
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.009 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0009 0.0009
Brugia malayi Steroid receptor seven-up type 2 0.002 0.014 0.0362
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0464 0.0897
Echinococcus multilocularis microtubule associated protein 2 0.0673 1 1
Trypanosoma cruzi kinesin, putative 0.0019 0.0132 0.0101
Loa Loa (eye worm) hypothetical protein 0.0045 0.0525 0.1357
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1648 1
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0132 0.0132
Schistosoma mansoni microtubule-associated protein tau 0.0673 1 1
Loa Loa (eye worm) glutaminase 0.0267 0.3867 1
Echinococcus multilocularis calpain 5 0.0019 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0362
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.009 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0132 0.0101
Brugia malayi calpain family protein 1 0.0064 0.0813 0.2103
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.014 0.014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.014 0.014
Loa Loa (eye worm) RNA binding protein 0.0062 0.0776 0.2006
Leishmania major hypothetical protein, conserved 0.0024 0.0212 0.0292
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1467 0.6628
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0132 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.014 0.0362
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.014 0.014
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1932 0.4421
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.014 0.014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.014 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.014 0.0362
Schistosoma mansoni hypothetical protein 0.0408 0.6 0.6
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.014 0.0362
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.6 0.6
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.014 0.0362
Schistosoma mansoni cpg binding protein 0.003 0.03 0.03
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.014 0.014
Brugia malayi nuclear receptor NHR-88 0.002 0.014 0.0362
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0132 0.0101
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1932 0.4421
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0362
Schistosoma mansoni cpg binding protein 0.0029 0.0276 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0776 0.0776
Trypanosoma cruzi kinesin, putative 0.0019 0.0132 0.0101
Brugia malayi Thioredoxin reductase 0.0047 0.0555 0.1436
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0132 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.014 0.0362
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1467 0.6628
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.014 0.0362
Schistosoma mansoni thyroid hormone receptor 0.002 0.014 0.014
Entamoeba histolytica protein kinase, putative 0.0019 0.0132 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0863 0.0863
Schistosoma mansoni thyroid hormone receptor 0.002 0.014 0.014
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0464 0.0897
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.014 0.014
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0776 0.2006
Echinococcus multilocularis cpg binding protein 0.003 0.03 0.03
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.009 0.5
Schistosoma mansoni coup transcription factor 0.002 0.014 0.014
Brugia malayi glutaminase DH11.1 0.0267 0.3867 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0276 0.0713
Echinococcus multilocularis calpain 0.0019 0.0132 0.0132
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1932 0.4421
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0464 0.0897
Brugia malayi calpain 7 0.0019 0.0132 0.0341
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0132 0.0132
Echinococcus multilocularis hypothetical protein 0.0019 0.0132 0.0132
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.014 0.0362
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0132 0.0101
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0132 0.0101
Brugia malayi TAR-binding protein 0.0062 0.0776 0.2006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.014 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0362
Echinococcus granulosus FTZ F1 alpha 0.002 0.014 0.014
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.014 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0362
Mycobacterium ulcerans glutaminase 0.0267 0.3867 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.014 0.0362
Echinococcus multilocularis calpain family protein 1, d 0.0045 0.0525 0.0525
Plasmodium vivax calpain, putative 0.0019 0.0132 0.0901
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.014 0.014
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0009 0.0009
Leishmania major trypanothione reductase 0.0047 0.0555 0.1117
Plasmodium falciparum thioredoxin reductase 0.0047 0.0555 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0025 0.0064
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0132 0.0101
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.014 0.014
Brugia malayi calpain 5 0.0019 0.0132 0.0341
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0256 0.371 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1648 0.75
Brugia malayi nuclear hormone receptor 0.002 0.014 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0362
Brugia malayi glutathione reductase 0.0047 0.0555 0.1436
Brugia malayi ecdysteroid receptor 0.002 0.014 0.0362
Echinococcus granulosus calpain 5 0.0019 0.0132 0.0132
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.009 0.009
Trichomonas vaginalis glutaminase, putative 0.0267 0.3867 1
Echinococcus granulosus cpg binding protein 0.003 0.03 0.03
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1648 0.75
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.014 0.014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.014 0.014
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0064 0.0813 0.0813
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0776 0.0776
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.014 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.014 0.0362
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0464 0.0897
Schistosoma mansoni cpg binding protein 0.003 0.03 0.03
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0212 0.2615
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0132 0.0101
Loa Loa (eye worm) glutathione reductase 0.0047 0.0555 0.1436
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0776 0.2006
Echinococcus granulosus calpain 0.0019 0.0132 0.0132
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.014 0.014
Toxoplasma gondii thioredoxin reductase 0.0047 0.0555 0.1285
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0132 0.0132
Echinococcus multilocularis calpain A 0.0068 0.0863 0.0863
Echinococcus granulosus calpain A 0.0068 0.0863 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.014 0.0362
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4256 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.014 0.0362
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.06 0.1223
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.014 0.014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.014 0.0362
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4256 1
Trypanosoma brucei kinesin, putative 0.0019 0.0132 0.0101
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.014 0.014
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.014 0.014
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0555 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0068 0.0863 0.0863
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1648 0.75
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.014 0.0362
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0662 0.1581
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0132 0.0101
Loa Loa (eye worm) glutaminase 2 0.0267 0.3867 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0025 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0212 0.0292
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0132 0.0101
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.014 0.014
Echinococcus granulosus dnaJ subfamily B 0.0408 0.6 0.6
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.014 0.0362
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.4256 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0212 0.2615
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.014 0.014
Onchocerca volvulus 0.0045 0.0525 1
Brugia malayi RNA binding protein 0.0062 0.0776 0.2006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0555 0.2239
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.014 0.014
Echinococcus granulosus calpain A 0.0019 0.0132 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0776 0.0776
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.014 0.014
Schistosoma mansoni nuclear hormone receptor 0.002 0.014 0.014
Plasmodium falciparum glutathione reductase 0.0047 0.0555 1
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0132 0.0132
Toxoplasma gondii hypothetical protein 0.0047 0.0555 0.1285
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0362
Mycobacterium ulcerans hypothetical protein 0.0154 0.2168 0.5501
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0009
Brugia malayi steroid hormone receptor 0.002 0.014 0.0362
Loa Loa (eye worm) hypothetical protein 0.0064 0.0813 0.2103
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0132 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0776 0.0776
Trypanosoma brucei antigen, putative 0.0019 0.0132 0.0101
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.4256 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0525 0.1357
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.014 0.014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.014 0.0362
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1467 0.6628
Leishmania major kinesin, putative 0.0019 0.0132 0.0101
Loa Loa (eye worm) calpain 5 0.0019 0.0132 0.0341
Brugia malayi hypothetical protein 0.0024 0.0212 0.0547

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.23 ug ml-1 Inhibition of glucan synthase in Candida albicans BWP17 membrane ChEMBL. 22687744
MIC100 (functional) = 8.35 ug ml-1 Antifungal activity against Candida albicans C693 by broth dilution method ChEMBL. 22687744

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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