Detailed information for compound 1653156

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.394 | Formula: C23H18FNO
  • H donors: 1 H acceptors: 1 LogP: 5.59 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Cc1ccc(cc1)c1[nH]c2ccccc2c(=O)c1C
  • InChi: 1S/C23H18FNO/c1-15-22(25-21-5-3-2-4-20(21)23(15)26)18-10-6-16(7-11-18)14-17-8-12-19(24)13-9-17/h2-13H,14H2,1H3,(H,25,26)
  • InChiKey: VMBCUYPHCLRGAH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0623 0.5046
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.1153 0.5274
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0148 0.0675
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.1153 0.5274
Loa Loa (eye worm) hypothetical protein 0.0031 0.0503 0.0892
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0011 0.0037 0.0065
Leishmania major glucose transporter, lmgt1 0.0032 0.0528 0.4091
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.053 0.0634
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.012 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0528 0.1973
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0262
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0148 0.0675
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1153 0.5274
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0065
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0255 0.1165
Onchocerca volvulus 0.002 0.0255 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0319 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.012 0.2954
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.564 1
Onchocerca volvulus Putative nachr subunit 0.002 0.0255 1
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.053 0.1983
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.1117 1
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.1117 0.5106
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0503 0.2302
Brugia malayi Cation transporter family protein 0.002 0.0255 0.0452
Onchocerca volvulus 0.0011 0.0037 0.1438
Loa Loa (eye worm) hypothetical protein 0.0032 0.053 0.094
Onchocerca volvulus 0.002 0.0255 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0148 0.0277
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0148 0.0028
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0255 0.0452
Trypanosoma brucei glucose transporter, putative 0.0032 0.0528 0.4091
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2187 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0148 0.0675
Echinococcus multilocularis solute carrier family 22 0.0014 0.012 0.0549
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0319 0.0565
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Plasmodium falciparum protein kinase 7 0.0288 0.6588 0.6546
Schistosoma mansoni sugar transporter 0.0014 0.012 0.0549
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.053 0.0415
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1117 0.4822
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0319 0.0961
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0255 0.1165
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0255 0.0452
Loa Loa (eye worm) GABA receptor subunit 0.0011 0.0037 0.0065
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Brugia malayi jmjC domain containing protein 0.0015 0.0148 0.0262
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Schistosoma mansoni protein kinase 0.0032 0.053 0.2423
Onchocerca volvulus 0.0014 0.012 0.4709
Schistosoma mansoni sugar transporter 0.0014 0.012 0.0549
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0037 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0319 0.0565
Echinococcus granulosus nAChR subunit 0.0011 0.0037 0.0167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0065
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2187 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0255 0.1165
Schistosoma mansoni neurotransmitter gated ion channel 0.0011 0.0037 0.0167
Echinococcus granulosus solute carrier family 22 0.0014 0.012 0.0549
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0255 0.1165
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0503 0.2302
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0319 0.1457
Brugia malayi hypothetical protein 0.0014 0.012 0.0213
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.053 0.0415
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0319 0.0201
Onchocerca volvulus 0.0014 0.012 0.4709
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0319 0.1457
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2187 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0255 0.0452
Schistosoma mansoni glucose transport protein 0.0102 0.2187 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.053 0.0415
Brugia malayi jmjC domain containing protein 0.0058 0.1153 0.2045
Brugia malayi follicle stimulating hormone receptor 0.0248 0.564 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.012 0.0549
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0528 0.1973
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0148 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Loa Loa (eye worm) hypothetical protein 0.0031 0.0503 0.0892
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0011 0.0037 0.0167
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.012 0.2954
Onchocerca volvulus 0.0014 0.012 0.4709
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0255 0.1165
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.012 0.0549
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0255 0.1165
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.053 0.2423
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0319 0.1993
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.1117 0.5106
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0262
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0255 0.1165
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0148 0.0675
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1117 0.4822
Onchocerca volvulus 0.002 0.0255 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1117 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Echinococcus multilocularis nAChR subunit 0.002 0.0255 0.1165
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0255 0.1165
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.053 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0528 0.1973
Leishmania major glucose transporter, lmgt2 0.0032 0.0528 0.4091
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.053 0.2423
Echinococcus multilocularis solute carrier family 22 0.0014 0.012 0.0549
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0148 0.0262
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0255 0.1165
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.053 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0528 0.1973
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0528 0.1973
Trypanosoma brucei glucose transporter 1E 0.0032 0.0528 0.4091
Brugia malayi Cation transporter family protein 0.002 0.0255 0.0452
Echinococcus multilocularis General substrate transporter 0.0088 0.1848 0.8454
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0503 0.2302
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0148 0.0675
Echinococcus granulosus General substrate transporter 0.0088 0.1848 0.8454
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0255 0.0452
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.053 0.094
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.053 0.2423
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Onchocerca volvulus 0.002 0.0255 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0148 0.0675
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0255 0.0452
Loa Loa (eye worm) hypothetical protein 0.0025 0.0368 0.0653
Brugia malayi hypothetical protein 0.0014 0.012 0.0213
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3679 0.5503
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0255 0.0452
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0319 0.0201
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0319 0.1993
Echinococcus granulosus solute carrier family 22 0.0014 0.012 0.0549
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0255 0.1165
Schistosoma mansoni nAChR subunit 0.002 0.0255 0.1165
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.012 0.0213
Brugia malayi Sugar transporter family protein 0.0014 0.012 0.0213
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0255 0.0452
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0255 0.0452
Onchocerca volvulus 0.0014 0.012 0.4709
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0255 0.1165
Onchocerca volvulus 0.0014 0.012 0.4709
Loa Loa (eye worm) sugar transporter 0.0102 0.2187 0.3877
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.053 0.2423
Schistosoma mansoni sugar transporter 0.0014 0.012 0.0549
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0528 0.1973
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0148 0.0262
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0065
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.1117 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0255 0.1165
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Brugia malayi Sugar transporter family protein 0.0014 0.012 0.0213
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.053 0.0415
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Plasmodium vivax hexose transporter 0.0102 0.2187 0.2092
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.1117 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0255 0.1165
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0255 0.0452
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0255 0.1165
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.1153 0.5274
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0148 0.0675
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0255 0.1165
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2187 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0255 0.1165
Trypanosoma brucei glucose transporter, putative 0.0032 0.0528 0.4091
Brugia malayi Cam kinase protein 1 0.0032 0.053 0.094
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0065
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0148 0.0043
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0255 0.1165
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0255 0.1165
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0255 0.1165
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0148 0.0262
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0065
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2187 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0528 0.4091
Schistosoma mansoni protein kinase 0.0032 0.053 0.2423
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0065
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.053 0.0415
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.053 0.2423
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.053 0.0634
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.053 0.2423
Schistosoma mansoni jumonji domain containing protein 0.0058 0.1153 0.5274
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0623 0.0509
Schistosoma mansoni sugar transporter 0.0014 0.012 0.0549
Schistosoma mansoni nAChR subunit 0.002 0.0255 0.1165
Loa Loa (eye worm) sugar transporter 0.0014 0.012 0.0213
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1153 0.2045
Echinococcus granulosus phd:f box containing protein 0.0015 0.0148 0.0675
Echinococcus multilocularis solute carrier family 22 0.0014 0.012 0.0549
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0473 0.2162
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0255 0.0452
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0078 0.0138
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2187 0.3195
Onchocerca volvulus 0.0014 0.012 0.4709
Trypanosoma brucei glucose transporter, putative 0.0032 0.0528 0.4091
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0037 0.0065
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0528 0.4091
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.012 0.0213
Schistosoma mansoni protein kinase 0.0032 0.053 0.2423
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2187 1
Onchocerca volvulus 0.0014 0.012 0.4709
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0148 0.0675
Schistosoma mansoni glucose transport protein 0.0102 0.2187 1
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.012 0.0213
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.012 0.0549
Onchocerca volvulus 0.0014 0.012 0.4709
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0528 0.4091
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0319 0.3046
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.1117 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.053 0.4113
Leishmania major glucose transporter, lmgt3 0.0032 0.0528 0.4091
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0255 0.1165
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.012 0.2954
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0011 0.0037 0.0065
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0148 0.0277
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0037 0.0065
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0255 0.1165
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Echinococcus granulosus nAChR subunit 0.002 0.0255 0.1165
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0148 0.0043
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.1117 0.5106
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3679 0.3603
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.053 0.0415
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.012 0.0213
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0255 0.1165
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0623 0.5046
Schistosoma mansoni hypothetical protein 0.0102 0.2187 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0528 0.4091
Brugia malayi major facilitator superfamily protein 0.0014 0.012 0.0213
Trypanosoma brucei glucose transporter 2A 0.0032 0.0528 0.4091
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0148 0.0675
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0319 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0255 0.0452
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0255 0.1165
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0255 0.0452
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0319 0.1457
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0528 0.4091
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2187 1
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0473 0.2162
Schistosoma mansoni nAChR subunit 0.002 0.0255 0.1165
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0255 0.0452
Trypanosoma brucei glucose transporter, putative 0.0032 0.0528 0.4091
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0503 0.3847
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0065
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0623 0.5046
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0528 0.1973
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0255 0.0452
Entamoeba histolytica hypothetical protein 0.0023 0.0319 0.5717
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0255 0.1165
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0623 0.5046
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.012 0.0549
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.053 0.2423
Schistosoma mansoni glucose transport protein 0.0102 0.2187 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Echinococcus granulosus solute carrier family 22 0.0014 0.012 0.0549
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0148 0.0675
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.012 0.0549
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1153 0.5274
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0503 0.2302
Brugia malayi jmjC domain containing protein 0.0015 0.0148 0.0262
Schistosoma mansoni nAChR subunit 0.002 0.0255 0.1165
Schistosoma mansoni glucose transporter 0.0014 0.012 0.0549
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Trypanosoma cruzi hexose transporter, putative 0.0017 0.019 0.0698
Plasmodium falciparum hexose transporter 0.0102 0.2187 0.2092
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2187 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.1117 0.5106
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0623 0.5046
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0255 0.0452
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.1153 0.5274
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0238 1
Brugia malayi hypothetical protein 0.0014 0.012 0.0213
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0255 0.0452
Onchocerca volvulus 0.0014 0.012 0.4709
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1117 1
Toxoplasma gondii protein kinase, putative 0.0288 0.6588 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3679 0.3603
Brugia malayi MAP kinase sur-1 0.0057 0.1117 0.198
Onchocerca volvulus 0.0014 0.012 0.4709
Trypanosoma brucei protein kinase, putative 0.0057 0.1117 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0623 0.0777
Schistosoma mansoni nAChR subunit 0.002 0.0255 0.1165
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0319 0.0307
Onchocerca volvulus 0.0014 0.012 0.4709
Onchocerca volvulus 0.0014 0.012 0.4709
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0255 0.0452
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0252 0.0641
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.1117 0.198
Brugia malayi Cation transporter family protein 0.002 0.0255 0.0452
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0011 0.0037 0.0167
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0255 0.1165
Trypanosoma cruzi hexose transporter 0.0032 0.0528 0.4091
Brugia malayi jmjC domain containing protein 0.0015 0.0148 0.0262
Leishmania major protein kinase, putative 0.0032 0.053 0.4113
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.012 0.0549
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Onchocerca volvulus 0.002 0.0255 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0319 0.1993
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0255 0.0452
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0319 0.1993
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0319 0.1457
Schistosoma mansoni nAChR subunit 0.002 0.0255 0.1165
Entamoeba histolytica protein kinase, putative 0.0032 0.053 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.053 0.2423
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2187 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.012 0.0213
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0528 0.4091
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0503 0.0892
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Trypanosoma brucei glucose transporter, putative 0.0032 0.0528 0.4091
Trypanosoma brucei glucose transporter, putative 0.0032 0.0528 0.4091
Plasmodium vivax JmjC domain containing protein 0.0015 0.0148 0.0028
Onchocerca volvulus 0.0011 0.0037 0.1438
Onchocerca volvulus 0.0014 0.012 0.4709
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0065
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0503 0.1855
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.053 0.094
Onchocerca volvulus Putative transporter 0.0014 0.012 0.4709
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0503 0.9461
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0255 0.1165
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0255 0.0452
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0528 0.4091
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0255 0.0452
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.1117 1
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0148 0.0675
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0148 0.0675
Brugia malayi major facilitator superfamily protein 0.0014 0.012 0.0213
Loa Loa (eye worm) ACC-1 protein 0.002 0.0255 0.0452
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0503 0.0892
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0255 0.1165
Loa Loa (eye worm) ACC-1 protein 0.002 0.0255 0.0452
Brugia malayi jmjC domain containing protein 0.0015 0.0148 0.0262
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0255 0.0452
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0255 0.1165
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1117 0.4822
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0255 0.0452
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0238 1
Onchocerca volvulus 0.002 0.0255 1
Onchocerca volvulus 0.0014 0.012 0.4709
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Schistosoma mansoni nAChR subunit 0.002 0.0255 0.1165
Entamoeba histolytica protein kinase, putative 0.0032 0.053 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0503 1
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0319 1
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.1117 0.5106
Brugia malayi Sugar transporter family protein 0.0102 0.2187 0.3877
Mycobacterium ulcerans sugar transporter 0.0014 0.012 0.2954
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1117 0.4822
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.1117 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.053 0.0634
Echinococcus granulosus solute carrier family 22 0.0014 0.012 0.0549
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0255 0.1165
Onchocerca volvulus 0.0014 0.012 0.4709
Loa Loa (eye worm) hypothetical protein 0.002 0.0255 0.0452
Loa Loa (eye worm) LGC-31 protein 0.002 0.0255 0.0452
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0528 0.4091
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.1117 0.1541
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0148 0.0675
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0255 0.1165
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.053 0.2423
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0623 0.0509
Trypanosoma brucei glucose transporter, putative 0.0032 0.0528 0.4091
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0255 0.1165
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0213
Echinococcus multilocularis nAChR subunit 0.0011 0.0037 0.0167
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.053 0.0415
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0148 0.0675
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0262
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.053 0.094
Onchocerca volvulus 0.0014 0.012 0.4709
Leishmania major hypothetical protein, conserved 0.0015 0.0148 0.0277
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0255 0.0452
Brugia malayi jmjC domain containing protein 0.0058 0.1153 0.2045

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 273 nM Antimalarial activity against atoquinone-resistant Plasmodium falciparum TM90C2B ChEMBL. 22364416

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 22364416

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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