Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Candida albicans | Involved in protection against oxidative damage | Starlite/ChEMBL | References |
Candida glabrata CBS 138 | Carbonic anhydrase | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | Carbonic anhydrase | 219 aa | 199 aa | 25.6 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0796 | 0.8928 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0551 | 0.493 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0551 | 0.493 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0551 | 0.493 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0587 | 0.5515 | 0.6177 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0312 | 0.1053 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.07 | 0.7365 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0341 | 0.1521 | 0.2065 |
Loa Loa (eye worm) | glutamate receptor | 0.0275 | 0.0449 | 0.0449 |
Schistosoma mansoni | carbonic anhydrase | 0.0551 | 0.493 | 0.5522 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0551 | 0.493 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0587 | 0.5515 | 0.5515 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0341 | 0.1521 | 0.1704 |
Loa Loa (eye worm) | glutamate receptor | 0.07 | 0.7365 | 0.7365 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0634 | 0.6293 | 0.8544 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0587 | 0.5515 | 0.5515 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0862 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.241 nM | Inhibition of human carbonic anhydrase-1 | ChEMBL. | 23206986 |
Ki (binding) | = 1.9 nM | Inhibition of human carbonic anhydrase-2 | ChEMBL. | 23206986 |
Ki (binding) | = 3.378 nM | Inhibition of human carbonic anhydrase-9 | ChEMBL. | 23206986 |
Ki (binding) | = 3.592 nM | Inhibition of human carbonic anhydrase-12 | ChEMBL. | 23206986 |
Ki (binding) | = 11 nM | Inhibition of human carbonic anhydrase 12 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 18 nM | Inhibition of human carbonic anhydrase 9 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 89 nM | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Ki (binding) | = 156 nM | Inhibition of recombinant full length Candida albicans NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Ki (binding) | = 541 nM | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 2470 nM | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.