Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Candida albicans | Involved in protection against oxidative damage | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Candida glabrata CBS 138 | Carbonic anhydrase | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | Carbonic anhydrase | 219 aa | 199 aa | 25.6 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0551 | 0.7293 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0663 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0663 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0663 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0551 | 0.7293 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0663 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0663 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0663 | 1 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0663 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0551 | 0.7293 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0551 | 0.7293 | 0.7293 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0551 | 0.7293 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0312 | 0.1557 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.49 nM | Inhibition of human carbonic anhydrase-1 | ChEMBL. | 23206986 |
Ki (binding) | = 1.827 nM | Inhibition of human carbonic anhydrase-2 | ChEMBL. | 23206986 |
Ki (binding) | = 3.679 nM | Inhibition of human carbonic anhydrase-9 | ChEMBL. | 23206986 |
Ki (binding) | = 3.855 nM | Inhibition of human carbonic anhydrase-12 | ChEMBL. | 23206986 |
Ki (binding) | = 5 nM | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Ki (binding) | = 6 nM | Inhibition of human carbonic anhydrase 12 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 9 nM | Inhibition of human carbonic anhydrase 9 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 84 nM | Inhibition of recombinant full length Candida albicans NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Ki (binding) | = 641 nM | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 1390 nM | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.