Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | References | |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.2469 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.019 | 1 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0178 | 0.9214 | 1 |
Brugia malayi | GMP reductase | 0.0079 | 0.2265 | 0.2265 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0082 | 0.2469 | 0.268 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0082 | 0.2469 | 0.268 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Leishmania major | basic transcription factor 3a, putative | 0.0082 | 0.2469 | 0.2469 |
Brugia malayi | beta-NAC-like protein | 0.0082 | 0.2469 | 0.2469 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.2469 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.019 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0082 | 0.2469 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 1 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.019 | 1 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0079 | 0.2265 | 0.5 |
Toxoplasma gondii | NAC domain-containing protein | 0.0082 | 0.2469 | 0.2469 |
Toxoplasma gondii | IMP dehydrogenas | 0.019 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.019 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 1 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.019 | 1 | 1 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0082 | 0.2469 | 0.2469 |
Loa Loa (eye worm) | GMP reductase | 0.0079 | 0.2265 | 0.2265 |
Trypanosoma brucei | GMP reductase | 0.019 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.019 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0079 | 0.2265 | 0.2265 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0082 | 0.2469 | 0.2469 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.2469 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.01 | 0.3714 | 0.0954 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0178 | 0.9214 | 0.8869 |
Loa Loa (eye worm) | ICD-1 protein | 0.0082 | 0.2469 | 0.2469 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.019 | 1 | 0.5 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0082 | 0.2469 | 0.2469 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.2469 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0079 | 0.2265 | 0.2265 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0178 | 0.9214 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.02 uM | Inhibition of inositol-5-monophosphate dehydrogenase (IMPDH) | ChEMBL. | 11462969 |
IC50 (binding) | = 0.02 uM | Inhibition of inositol-5-monophosphate dehydrogenase (IMPDH) | ChEMBL. | 11462969 |
IC50 (binding) | = 1.8 uM | In vitro inhibition of inosine Inosine-5'-monophosphate dehydrogenase | ChEMBL. | 1967654 |
IC50 (binding) | = 1.8 uM | In vitro inhibition of inosine Inosine-5'-monophosphate dehydrogenase | ChEMBL. | 1967654 |
IC50 (functional) | = 4.8 uM | In vitro inhibition of human lymphocyte proliferation in response to phytohaemagglutinin (PHA) was determined | ChEMBL. | 1967654 |
IC50 (functional) | = 4.8 uM | In vitro inhibition of human lymphocyte proliferation in response to pokeweed mitogen(PWM) was determined | ChEMBL. | 1967654 |
IC50 (functional) | = 4.8 uM | In vitro inhibition of human lymphocyte proliferation in response to staphylococcus protein A(SPA) was determined | ChEMBL. | 1967654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.