Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Candida albicans | Involved in protection against oxidative damage | Starlite/ChEMBL | References |
Candida glabrata CBS 138 | Carbonic anhydrase | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | Carbonic anhydrase | 219 aa | 199 aa | 25.6 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.08 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0722 | 0.8785 | 0.8785 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0238 | 0.1248 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.08 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0642 | 0.7539 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0238 | 0.1248 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0722 | 0.8785 | 0.8785 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.08 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.08 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0642 | 0.7539 | 0.7539 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.018 | 0.035 | 0.035 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0642 | 0.7539 | 0.7539 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.14 | 0.14 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.018 | 0.035 | 0.035 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.14 | 0.14 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.08 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.14 | 0.14 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.07 | 0.8435 | 0.8435 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.14 | 0.14 |
Loa Loa (eye worm) | TK protein kinase | 0.0722 | 0.8785 | 0.8785 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.08 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.035 | 0.035 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.08 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.14 | 0.14 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.08 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0551 | 0.6115 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0551 | 0.6115 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.08 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.14 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0722 | 0.8785 | 0.8785 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.14 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.08 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.08 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0551 | 0.6115 | 1 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0642 | 0.7539 | 0.7539 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.035 | 0.035 |
Echinococcus granulosus | c src tyrosine kinase | 0.018 | 0.035 | 0.035 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0722 | 0.8785 | 0.8785 |
Brugia malayi | protein-tyrosine kinase | 0.0722 | 0.8785 | 0.8785 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0722 | 0.8785 | 0.8785 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.14 | 0.14 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.14 | 0.14 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.018 | 0.035 | 0.035 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0722 | 0.8785 | 0.8785 |
Schistosoma mansoni | carbonic anhydrase | 0.0551 | 0.6115 | 0.6115 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.08 | 1 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0312 | 0.2406 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.08 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.08 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.08 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.018 | 0.035 | 0.035 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.08 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.08 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.08 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.14 | 0.14 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.08 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.07 | 0.8435 | 0.8435 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.14 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.018 | 0.035 | 0.035 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.018 | 0.035 | 0.035 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.08 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.123 nM | Inhibition of human carbonic anhydrase-1 | ChEMBL. | 23206986 |
Ki (binding) | = 2.039 nM | Inhibition of human carbonic anhydrase-2 | ChEMBL. | 23206986 |
Ki (binding) | = 3.429 nM | Inhibition of human carbonic anhydrase-9 | ChEMBL. | 23206986 |
Ki (binding) | = 3.633 nM | Inhibition of human carbonic anhydrase-12 | ChEMBL. | 23206986 |
Ki (binding) | = 9.6 nM | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Ki (binding) | = 10 nM | Inhibition of human carbonic anhydrase 12 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 16 nM | Inhibition of human carbonic anhydrase 9 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 141 nM | Inhibition of recombinant full length Candida albicans NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Ki (binding) | = 393 nM | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 393 nM | Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Ki (binding) | = 3240 nM | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.